International Archives of

Clinical PharmacologyISSN: 2572-3987

Current Issue

 Open Access DOI:10.23937/2572-3987.1510013

Novel Concepts for Clinical Pharmacology from "Calcium Paradox" due to Neuronal Interaction between Signalling Pathways Mediated by Ca2+ and cAMP: from 1975 to 2017

Leandro Bueno Bergantin and Afonso Caricati-Neto

Article Type: Mini Review | First Published: November 24, 2017

The solution for the so-called "calcium paradox" has been revealed 4 years ago, when we demonstrated the involvement of the interaction between Ca2+ and cAMP signalling pathways (Ca2+/cAMP signalling interaction) in this enigma....

 Open Access DOI:10.23937/2572-3987.1510012

Dietary Flavonoids and Colorectal Cancer: Evidence from Epidemiological Studies

Katrin Sak

Article Type: Review Article | First Published: October 11, 2017

Identification of dietary agents related to colorectal carcinogenesis is of high importance to decrease the global burden of this severe disorder. As flavonoids abundantly present in plant-based food items are suggested to exert various anticancer activities in numerous experimental models, evidence from epidemiological studies about association....

 Open Access DOI:10.23937/2572-3987.1510011

Prolonged Coagulopathy Following Rattlesnake Envenomation Responsive to Antivenom: A Case Report

Megan Z Roberts, Brian P McKinzie, Stuart M Leon, Stephen A Fann and Nicole M Bohm

Article Type: Case Report | First Published: July 19, 2017

Venom-specific immunoglobulin G fragments are used for the management of patients with North American crotalid envenomation. In this case, ongoing coagulopathy and clinically significant sequelae required a protracted course of antivenom therapy in a patient experiencing severe rattlesnake envenomation....

 Open Access DOI:10.23937/2572-3987.1510010

Pharmaceutical Characterization and Detection Using Surface-Enhanced Raman Scattering

Tawfik A Saleh

Article Type: Review Article | First Published: April 07, 2017

Surface-enhanced Raman scattering (SERS) is a surface sensitive method that results in the enhancement of Raman scattering by molecules adsorbed on rough metal surfaces. The enhancement factor can be as much as 107 -1015, which allows the technique to be sensitive enough to detect single molecules....

 Open Access DOI:10.23937/2572-3987.1510009

Levothyroxine for Hypothyroidism: Current Status of Biowaiver and Bioequivalence Studies

Nunez-Guzman NA, Munoz-Ibarra AI, Ruiz-Molina D, Figueroa-Nunez B and Garcia-Perez ME

Article Type: Review Article | First Published: January 24, 2017

Hypothyroidism is a common disease that needs to be closely treated, in order to reduce adverse symptoms and pathophysiological effects. For thyroid hormone replacement is preferred a therapy with a synthetic form of thyroxine (levothyroxine), a drug recognized by its Narrow Therapeutic Index. Generic levothyroxine can be an economic alternative for Hypothyroidism treatment....

Volume 3
Issue 1