Journal of

Toxicology and Risk AssessmentISSN: 2572-4061

Current Issue

 Open Access DOI:10.23937/2572-4061.1510020

Repeated Intravenous Dose Toxicity of Di-Isononyl Phthalate in Male Sprague-Dawley Rats

Yanping Xue, Ning Chen, Tao Jiang

Article Type: Research Article | First Published: March 22, 2019

The systemic toxic effects of di-isononyl phthalate (DINP) were evaluated in a 4-wk study in male Sprague-Dawley rats. The animals were administered DINP intravenously at dosages of 125, 250, and 500 mg/kg every other day for 4 wk. The control and the positive control group were administered vehicle (egg yolk phosphatides plus glycerol solutions) and 500 mg/kg di(2-ethylhexyl) phthalate (DEHP), respectively. Clinical signs were observed immediately after administration and consumption of food, a...

 Open Access DOI:10.23937/2572-4061.1510019

Risk Assessment and Communication in Pharmaceuticals: Recognizing the Differences in Occupational Health and Medication Safety

Vivian SW Chan Fung

Article Type: RESEARCH ARTICLE | First Published: March 06, 2019

Pharmaceuticals are the most common medical intervention. Ensuring workers and members of the public get the most benefits from advances in modern medicine is a critical component of improving the health care system. Pharmaceuticals bring healing to patients but increased risk of illness have been reported among workers manufacturing, handling and administering pharmaceutical products with inadequate attention to personal safety. Their potential for both helping and harming human health can be p...

 Open Access DOI:10.23937/2572-4061.1510018

Heavy Metals Contents and Risk Assessment of Farmland on the Edge of Sichuan Basin

Mengling Yang, Dan Zhang, Lu Xu, Shamshad Khan, Fan Chen and Hao Jiang

Article Type: RESEARCH ARTICLE | First Published: March 04, 2019

This study features a survey of the concentrations of heavy metals (Cu, Cd, Cr, Ni, Pb, Mn, Co, Se) in surface soils (0-30 cm), carried out in edge of Sichuan Basin (Pingdi, Puan, Xingwen, Gulin). The contamination of heavy metals in soil was assessed with single-factor pollution index method and Nemerow comprehensive pollution index method. The results showed that Cu, Cr, Ni, Pb, Co were main risk factors of soil heavy metal pollution. In Gulin, the concentrations of Cd, Mn and Se were higher t...

 Open Access DOI:10.23937/2572-4061.1510017

Plastic Additive Bisphenol A: Toxicity in Surface- and Groundwater Crustaceans

Gerhardt A

Article Type: Research Article | First Published: January 16, 2019

Bisphenol A (BPA) is being considered by the European Union as a substance of very high concern, occurring worldwide due to its wide application in many plastic products, building materials, coatings and epoxy resins. The toxicity of BPA in groundwater invertebrates is insufficiently understood. Both acute (24 h) and chronic (28 d) toxicity was compared in Daphnia magna and ecologically important crustaceans in surface water (Gammarus fossarum, Eucyclops serrulatus) and groundwater (Niphargopsis...

 Open Access DOI:10.23937/2572-4061.1510016

A New QSAR Model for Acute Fish Toxicity based on Mined Structural Alerts

Giuseppina Gini, Thomas Ferrari, Anna Lombardo, Antonio Cassano and Emilio Benfenati

Article Type: Research Article | First Published: January 14, 2019

In this paper we discuss the problem of predicting the fish toxicity property of chemical compounds, and show how this can be approached using a computational intelligence method. There are two views on assessing toxicities: One says that such properties can be derived from the whole molecular structure, the other that some specific functional substructures, called Structural Alerts (SA), are able to explain the toxicity. In this work, a new Structure-Activity Relationship (SAR) approach is prop...

Volume 5
Issue 1