Repeated Intravenous Dose Toxicity of Di-Isononyl Phthalate in Male Sprague-Dawley Rats
Yanping Xue, Ning Chen, Tao Jiang
Article Type: Research Article | First Published: March 22, 2019
The systemic toxic effects of di-isononyl phthalate (DINP) were evaluated in a 4-wk study in male Sprague-Dawley rats. The animals were administered DINP intravenously at dosages of 125, 250, and 500 mg/kg every other day for 4 wk. The control and the positive control group were administered vehicle (egg yolk phosphatides plus glycerol solutions) and 500 mg/kg di(2-ethylhexyl) phthalate (DEHP), respectively. Clinical signs were observed immediately after administration and consumption of food, a...
Heavy Metals Contents and Risk Assessment of Farmland on the Edge of Sichuan Basin
Mengling Yang, Dan Zhang, Lu Xu, Shamshad Khan, Fan Chen and Hao Jiang
Article Type: RESEARCH ARTICLE | First Published: March 04, 2019
This study features a survey of the concentrations of heavy metals (Cu, Cd, Cr, Ni, Pb, Mn, Co, Se) in surface soils (0-30 cm), carried out in edge of Sichuan Basin (Pingdi, Puan, Xingwen, Gulin). The contamination of heavy metals in soil was assessed with single-factor pollution index method and Nemerow comprehensive pollution index method. The results showed that Cu, Cr, Ni, Pb, Co were main risk factors of soil heavy metal pollution. In Gulin, the concentrations of Cd, Mn and Se were higher t...
Plastic Additive Bisphenol A: Toxicity in Surface- and Groundwater Crustaceans
Article Type: Research Article | First Published: January 16, 2019
Bisphenol A (BPA) is being considered by the European Union as a substance of very high concern, occurring worldwide due to its wide application in many plastic products, building materials, coatings and epoxy resins. The toxicity of BPA in groundwater invertebrates is insufficiently understood. Both acute (24 h) and chronic (28 d) toxicity was compared in Daphnia magna and ecologically important crustaceans in surface water (Gammarus fossarum, Eucyclops serrulatus) and groundwater (Niphargopsis...
A New QSAR Model for Acute Fish Toxicity based on Mined Structural Alerts
Giuseppina Gini, Thomas Ferrari, Anna Lombardo, Antonio Cassano and Emilio Benfenati
Article Type: Research Article | First Published: January 14, 2019
In this paper we discuss the problem of predicting the fish toxicity property of chemical compounds, and show how this can be approached using a computational intelligence method. There are two views on assessing toxicities: One says that such properties can be derived from the whole molecular structure, the other that some specific functional substructures, called Structural Alerts (SA), are able to explain the toxicity. In this work, a new Structure-Activity Relationship (SAR) approach is prop...