International Journal of

Diabetes and Clinical ResearchISSN: 2377-3634

Current Issue

 Open Access DOI:10.23937/2377-3634/1410125

Prevalence of Type 1 Diabetes and Presence of Optimal Support Services in Public Schools a Case Study of Gweru, Zimbabwe

Miriraishe Chigova and Prosper Chopera

Article Type: Research Article | First Published: June 10, 2020

Type 1 diabetes sometimes referred to as childhood onset diabetes is characterized by deficient hormone insulin production by the body. Children spend most of their time in school such that when there is an imbalance between medication, food and physical activity the wellbeing of the minor is placed at risk. The main objective was to investigate the prevalence of Type 1 diabetes and presence of support services for affected children in public schools in Gweru, Zimbabwe....

 Open Access DOI:10.23937/2377-3634/1410124

Educational Intervention Impacts on Knowledge and Performance of Self-Care Practices among Type 2 Diabetes Mellitus Patients in Selected Hospitals in Southwestern, Nigeria

Oluwaseun Oluwafunmilayo Abiodun, Adenike Ayobola E Olaogun and Adewale Oladayo Akinpelu

Article Type: Original Article | First Published: June 06, 2020

Neglecting the importance of adequate knowledge and correct performance of self-care practices are major causes of many complications that are experienced by T2DM patients. The objective of this study was to assess the impact of educational intervention on the level of knowledge and performance of self-care practices among patients with T2DM in selected tertiary hospitals. A quasi-experimental design that utilized purposive sampling method was used. The study was conducted at the University of M...

 Open Access DOI:10.23937/2377-3634/1410122

Economic Assessment of Direct Cost of Illness of Diabetes Mellitus at Dessie Referral Hospital, North East Ethiopia

Zinash Alemu, Birhanu Demeke Workneh, Solomon Ahmed Mohammed and Moges Workneh Ayele

Article Type: Research Article | First Published: May 06, 2020

Cross-sectional study was conducted on 217 participants from November 30, 2016 to December 31, 2017, and data were extracted from patients registries and analyzed using SPSS version 20. Linear regression was used to assess the statistically significant difference in the cost of treatment of diabetes. The study calculated direct medical and non- medical costs by multiplying the quantity of each service by their respective unit costs. The total direct medical and non-medical costs per year were 12...

 Open Access DOI:10.23937/2377-3634/1410123

Renoprotective Effect of Co-Enzyme Q10 and N-Acetylcysteine on Streptozotocin-Induced Diabetic Nephropathy in Rats

Manojkumar S Mahajan, Chandrashekhar D Upasani, Aman B Upaganlawar and Vishal S Gulecha

Article Type: Original Article | First Published: May 21, 2020

Persistent chronic hyperglycemia is an important player in the development and progression of diabetic nephropathy (DN) due to generation of oxidative stress (OS) which is at the center in the pathophysiology of DN and underlying kidney damage. The present study was aimed to evaluate the effect of antioxidants like Co-enzyme Q10 (CoQ10) and N-acetylcysteine (NAC) either alone or in combination in streptozotocin (STZ) induced diabetic nephropathy (DN) in rats....

 Open Access DOI:10.23937/2377-3634/1410121

The Use of Artifical Intelligence in Assessing Glucose Variability in Individuals with Diabetes Type 2 from Routine Primary Care Data

Ljiljana Trtica Majnarić, MD, PhD, František Babič, MSc, PhD, Zvonimir Bosnić, Marijana Zekić- Sušac, PhD and Thomas Wittlinger, MD, PhD

Article Type: Original Article | First Published: May 06, 2020

A-proof-of-concept study, conducted in primary care. A total of 63 variables were used from electronic health records to describe clinical characteristics of 110 individuals with diabetes type 2 of both gender, 40-86 years old (average 62.69), and on treatment with oral hypoglycaemic drugs. The artificial neural networks (ANN) of machine learning techniques was used to model inter-day glucose variability based on the estimation of variances (the square of the standard deviation) of sporadically ...

 Open Access DOI:10.23937/2377-3634/1410116

Effect of CoQ10 Supplementation on Oxidative Stress and Muscle Bioenergetics in Type II Diabetes: A Pilot Study

Joohee Sanders, PhD, Sinclair Smith, PhD and Carsten Sanders, PhD

Article Type: Original Article | First Published: January 30, 2020

To compare oxidative stress, mitochondrial oxidative phosphorylation capacity, microvascular function, and exercise performance of type II diabetics (T2D) to that of control subjects and to determine whether Co-enzyme Q10 (CoQ10) supplementation has any effects on these measures. Noted reduction in MDA seen in healthy, older individuals suggests a positive antioxidant effect of CoQ10 supplementation. However, when PAD is present, as can be the case of T2D, two weeks of CoQ10 supplementation at 2...

 Open Access DOI:10.23937/2377-3634/1410115

Prevalence of Diabetes Mellitus in Outpatients with Essential Hypertension in a Rural Tertiary Hospital

Ogunmola Olarinde Jeffrey, Ajani Gbadebo Oladimeji and Olabinri Eunice Oluremi

Article Type: Original Article | First Published: December 16, 2019

To determine the prevalence of diabetes mellitus (DM) in patients with essential hypertension attending outpatient medical clinic in a rural community setting of a developing country. This cross-sectional study included patients of a medical outpatient clinic in Federal Teaching Hospital Ido Ekiti, Ekiti State, Nigeria. Study patients were consecutively recruited from Cardiac clinic and baseline investigations obtained from the patients’ files were evaluated including Fasting Blood Glucose (FB...

 Open Access DOI:10.23937/2377-3634/1410114

Type 2 Diabetes Prevalence, Distribution and Risk Factors in St. Kitts and Nevis, West Indies

Jeanita W Richardson, Kelsie D Kelly, Trina K Kumodzi, Nicole Slack Liburd and Hazel Laws, MD

Article Type: Original Article | First Published: November 28, 2019

This study in collaboration with the St. Kitts & Nevis Ministry of Health (MOH) investigated the prevalence of type 2 diabetes and its risk factors, the second leading cause of death in the country. Medical records of patients between the ages of 18 and 75 as of January 1, 2010 treated between January 1, 2010 and December 31, 2015 in the government-funded health centers (HCs) were eligible for inclusion (N = 2737). All HC visits (n = 4169) generated by a representative sample of patients (n = 76...

 Open Access DOI:10.23937/2377-3634/1410113

Effect of Antihypertensive Agents on Biochemical Parameters in Diabetic Patients in Taif - KSA

Niveen M. Daoud, Ola A. Qadi, Dania O. Al-talhi and Hanan Kamal Al-sharabi

Article Type: Clinical Study | First Published: October 21, 2019

Hypertension and diabetes mellitus are chronic medical conditions that frequently coexist. Our objective is to evaluate the effect of Angiotensin converting enzyme inhibitors and Angiotensin II receptor blockers comparatively and in integration with Metformin, dipeptidyl 4 inhibitors and insulin on lipid profile, serum creatinine, liver enzymes and electrolytes in type II diabetic patients. Hypertension and diabetes mellitus are chronic medical conditions that frequently coexist. Obesity, high s...

 Open Access DOI:10.23937/2377-3634/1410098

Insulin Acts as Stimulatory Agent in Diabetes-Related Escherichia Coli Pathogenesis

amelija Madacki-Todorovic, Izet Eminovic, Nadira Ibrisimovic Mehmedinovic and Mirza Ibrisimovic

Article Type: Research Article | First Published: December 05, 2018

In general, diabetic patients are more prone to microbial infections, which is believed to be caused due to high glucose levels in blood which compromise components of the immune system. However, it is little known about role of therapeutic insulin administration on dissemination of infectious diseases in people with diabetes mellitus. The study included the clinically isolated strains of Escherichia coli (E. coli) with biofilm forming capacity as well as referent non-biofilm former E. coli stra...

 Open Access DOI:10.23937/2377-3634/1410097

Incidence of Urinary Tract Infections and Allergic Conditions among Type 2 Diabetes Mellitus Patients in Rural Hospital Clinics in Sri Lanka

JGA Sachinthana, GM Kariyawasam, EMDT Edirisinghe, HSN Peiris, DARK Dayara-thna, FM Mowlana and JMKB Jayasekara

Article Type: Research Article | First Published: November 07, 2018

Urinary tract infections (UTI) and allergic conditions in individuals with diabetes mellitus (DM) may evolve to serious complications unless managed properly. Early diagnosis and evaluation of these conditions of DM pa-tients are important to maintain the quality of life of the patients. The objective of the current study was to identify the incidence of UTIs among type 2 DM patients....

 Open Access DOI:10.23937/2377-3634/1410096

Insulin Resistance Modification is a Game Changer for Type 2 Diabetes Treatment Strategy

Juraj Gmitrov

Article Type: Review Article | First Published: October 15, 2018

Insulin resistance, appearing years before diabetes main diagnostic sign, hyperglycemia, stands in the origin of type 2 diabetes (T2DM), generated by complex impairment of a spectrum biochemical processes the most important of which is the failure of phosphatidylinositol 3-kinase enzymatic chain responsible for glucose uptake and endothelial nitric oxide (NO) synthase activation. Therefore in conditions with insulin resistance the impairment of glucose uptake is strongly coupled with NO deficit ...

 Open Access DOI:10.23937/2377-3634/1410095

Zinc Supplementation Attenuated Calcium-High Diet Effect on Zinc Status and Carbohydrate Metabolism of Non-Diabetic and Diabetic Rats

Samir Derouiche and Zine Kechrid

Article Type: Original Article | First Published: October 03, 2018

The bioavailability of zinc can be influenced by several dietary factors, among them calcium level, which leads to zinc metabolism disturbance. Thus, the present study was under taken to evaluate the effect of zinc supplementation on zinc status and carbohydrate metabolism in non-diabetic and diabetic rats fed high-calcium diet. Diabetes is a group of metabolic disorders characterized by chronic hyperglycemia resulting from disorders of secretion or the action of insulin. This hyperglycemia is a...

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