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Case Report 

Blue Fingernails during Treatment with Cyclophosphamide for Minimal Change Disease: A Very Rare Side Effect

Rollino Cristiana, Giulietta Beltrame, Roberta Fenoglio, Michela Ferro, Paola Mesiano, Giacomo Quattrocchio and Dario Roccatello
Abstract

We present the case of a 52-year-old lady affected with cortico dependent minimal change disease who developed a blue pigmentation of her fingernails during a 3-months treatment with cyclophosphamide for cortico dependent minimal change disease. The typical manifestation of onset of Minimal Change Disease (MCD) is a pure nephrotic syndrome.

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Case Report 

The Biliary Sinus: A Rare Late-Stage Complication of Cholecystectomy

Ihsan Yildiz, Yavuz Savas Koca and Ibrahim Barut
Abstract

A 53-year-old female patient who had undergone open cholecystectomy due to cholelithiasis 6 years earlier was admitted to hepatobiliary surgery unit with a painful mass in the right upper quadrant and fever. Ultrasonography showed that a 3-cm fluid-filled mass in the right upper quadrant subcutaneously, in computed tomography a fluid-filled tubular lesion extending from the right lobe of liver to right upper quadrant, and percutaneous cholangiography showed that a radio-opaque density communicating with the liver. The biliary sinus tract was totally excised. The patient was uneventfully discharged on day 6 after the surgery. Histopathological examination of the lesion was reported as a bile sinus.

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Case Report 

Left Atrial Appendage Occluder with Recurrent Thrombus Formation Visualized by Three-Dimensional Transesophageal Echocardiography

Sebastian Greiner and Hugo A Katus
Abstract

A 78-year-old Caucasian female with newly diagnosed atrial fibrillation was put on anticoagulation with phenprocoumon. Two months later she developed an intracranial hemorrhage localized in the brainstem. Neurological findings were paresis and paraesthesia of the left body side. The treatment was conservative and symptoms resolved within three months.

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Case Report 

Chemotherapeutic Agents for Brain Metastases in Non-Small Cell Lung Cancer: A Case Report with Eribulin Mesylate and Review of the Literature

Alejandra C Fuentes, Reordan O De Jesus and David N Reisman
Abstract

Lung cancer accounts for the majority of cases of brain metastases, resulting in higher morbidity and mortality. Surgery and radiation are the current standard of care for the treatment of brain metastases. However, when brain metastases recur despite these treatments, the management options are limited, especially when recurrent metastatic events occur. The role of systemic chemotherapy for brain metastases remains undefined, with advances in drug delivery and ongoing studies using targeted agents showing promising results.

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Case Report 

The Use of the Gallbladder Wall for Reconstruction of the Extrahepatic Bile Ducts in a Case of Agenesis of the Common Bile Duct: A Case Report

Maher N Ghabriel
Abstract

Unexpected anomalies of the extrahepatic biliary ducts were found intraoperatively during open cholecystectomy in a 49-year-old male, with calcular obstructive jaundice. The patient had congenital absence of the common bile duct that appears to have been replaced by the cystic duct, which opened directly into the duodenum. The right and left hepatic ducts drained into the posterior wall of the gallbladder by a short common hepatic duct. Intraoperatively the gallbladder wall (with uncompromised nerve and blood supply) was used as a vital flap to reconstruct a tubular bridge across the defect in the biliary ducts, while retaining a functional sphincter of Oddi at the end of the original cystic duct.

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Review Article 

The Spread of Melanoma to the Adrenal Glands: Historical Cases

Wilson I B Onuigbo
Abstract

Personal interest in cancer metastasis to the adrenal glands began in 1957 and matured in a Doctorate Thesis in 1961. Part of its eminence lay in cases in which it was the only soil selected for attack. What of the melanoma? The available historical account did not contain this answer. Therefore, this paper aims to determine the situation in the classical Transactions of the Pathological Society of London, which began to publish during the 1846 - 1848 period.

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Case Report 

Neurobiology of KB220Z-Glutaminergic-Dopaminergic Optimization Complex [GDOC] as a Liquid Nano: Clinical Activation of Brain in a Highly Functional Clinician Improving Focus, Motivation and Overall Sensory Input Following Chronic Intake

Lucien L Duquette, Frank Mattiace, Kenneth Blum, Roger L Waite, Teresa Boland,Thomas McLaughlin1, Kristina Dushaj, Marcelo Febo and Rajendra D Badgaiyan
Abstract

With neurogenetic and epigenetic tools utilized in research and neuroimaging, we are unraveling the mysteries of brain function, especially as it relates to Reward Deficiency Syndrome (RDS). We encourage the development of pharmaceuticals or nutraceuticals that promote a reduction in dopamine resistance and balance brain neurochemistry, leading to dopamine homeostasis. We disclose self-assessment of a highly functional professional under work-related stress following KB220Z use, a liquid (aqua) nano glutaminergic-dopaminergic optimization complex (GDOC).

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