Peripheral T cell lymphoma (TCL) is relatively uncommon and may involve lymph node, skin and extra-nodal non-cutaneous organs. Nodal TCL often presents as systemic disease with unfavorable outcomes. Extra-nodal non-cutaneous TCL, however, may remain as localized disease and be treated differently with favorable prognosis. This study revealed the common peripheral blood findings and clinical follow ups in patients with extra-nodal non-cutaneous mature TCL. There were 9 patients, 5 males and 4 females, median age 52, including 1 extra-nodal NK/T cell lymphoma, nasal type; 1 anaplastic large cell lymphoma, ALK-negative; 1 enteropathy associated T cell lymphoma and 6 peripheral TCL, not otherwise specified. No patients showed concurrent bone marrow, lymph node or cutaneous involvement by combined pathological and clinical studies. Seven patients had anemia; with associated lymphopenia in 2 patients, thrombocytopenia and thrombocytosis in 1 patient each. Three patients received CHOP chemotherapy; 1 with radiation therapy and subsequent chemotherapy; 4 with surgical procedures and 1 with conservative management only. Two patients died of disease after chemotherapy. Seven patients were in remission or alive with disease. Anemia was common in patients with extra-nodal non-cutaneous TCL, which made the patient management more challenging. In comparison with nodal TCL, extra-nodal non-cutaneous TCL in this study remained as localized disease without systemic involvement. Clinical management was more variable with fewer patients receiving chemotherapy. Surgical treatment alone and conservative management were the treatment of choice in more patients with relatively favorable clinical outcome.