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International Journal of
Allergy Medications ISSN: 2572-3308

Citation

Sheikh F, Sumayli S, Hakami H, Khaliq AMR, Al Gazlan S, et al. (2018) Thrombocytopenia in a Patient with Severe Combined Immune Deficiency: An Unusual Cause. Int J Aller Medications 4:035. doi.org/10.23937/2572-3308.1510035

Copyright

© 2018 Sheikh F, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

SHORT COMMUNICATION | OPEN ACCESS DOI: 10.23937/2572-3308.1510035

Thrombocytopenia in a Patient with Severe Combined Immune Deficiency: An Unusual Cause

Farrukh Sheikh1*, Safiah Sumayli1, Hasan Hakami2, Agha M Rehan Khaliq1,3, Sulaiman Al Gazlan1, Hasan Alrayes1, Ghuzayel Al-Dawsari4, Riad El Fakih4 and Rand Arnaout1,3,5

1Department of Medicine, Section of Allergy and Immunology, King Faisal Specialist Hospital & Research Centre, Riyadh, Kingdom of Saudi Arabia

2Department of Medicine, King Faisal Specialist Hospital and Research Center, Riyadh, Kingdom of Saudi Arabia

3Alfaisal University, Riyadh, Kingdom of Saudi Arabia

4Oncology Center, Section of Adult Hematology/HSCT, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia

5Department of Pediatric, Section of Allergy and Immunology, King Faisal Specialist Hospital and Research Center, Riyadh, Kingdom of Saudi Arabia

Abstract

We report the first case of severe intractable thrombocytopenia in a patient with adenosine deaminase deficiency, Severe Combined Immune Deficiency (SCID), necessitating hematopoietic stem cell transplant. This patient developed severe thrombocytopenia from polyethylene glycol adenosine deaminase and needed a hematopoietic stem cell transplant as an adolescent. She did well afterwards, overall. Although rare, thrombocytopenia can result from polyethylene glycol adenosine deaminase. Hematopoietic stem cell transplant may be an option in SCID patients with intractable thrombocytopenia, even at a later age.