Neuroendocrine Small cell Carcinoma (SCC) of the urinary bladder is a rare tumor. Pure Small Cell Carcinoma is uncounted from 0.5 to 1% of all primitive urinary tumors. The diagnosis is based on transurethral resection. The old age, and smoking are putative risk factors. A genetic predisposition is unknown.
Pure SCC of the bladder display metastasis and lymph nodes. Viscera and vertebral bones are the most common sites of the metastasis. Painless gross hematuria is the most common clinical feature. The prognosis is very poor. The overall survival rate at five years, in advanced stages does not exceed 8%.
SCC of the urinary bladder can be treated with local resection of the tumor or radical cystectomy with neoadjuvant or adjuvant chemotherapy. Radiation therapy is used as an alternative to radical cystectomy or as a palliative measure.