International Journal of

Neurodegenerative DisordersISSN: 2643-4539

Archive

 Open Access DOI:10.23937/2643-4539/1710025

Medium-Term Effect of Pedunculopontine Nucleus Neurotoxic Lesion on Motor Function and Gene Expression of Protein Related to Dopaminergic Homeostasis in Rat

Lisette Blanco-Lezcano, María Elena González-Fraguela, Guadalupe Zaldívar-Lelo de Larrea, Rosa Martha Pérez-Serrano, María Daniela Frade-Pérez, Teresa Serrano-Sánchez and Liliana Francis Turner

Article Type: Original Article | First Published: 2023/04/14

The hypothesis that early degeneration of the pedunculopontine nucleus (PPN) may be related to nigral degeneration has opened new avenues of basic research for this disease. It is not known how the motor function and nigrostriatal gene expression of TH, VMAT2 and DAT behave in an intermediate term (30 days) following the pontine lesion....

Volume 6
Issue 1