Open Access DOI:10.23937/2377-4630/1/3/1015

Endotracheal Repair of an Iatrogenic Tracheal Laceration in A 83-Year-Old Critically Ill Woman with Aspiration Pneumonitis and Sepsis

Stefan Welter, Danjouma Cheufou, Thomas Ehmann, Sandra Kampe and Peter Scharmann

Article Type: Case Report | First Published: November 24, 2014

Tracheal laceration is a rare complication of emergency intubation. The treatment decision depends on severity of accompanying problems, available resources, condition and perspectives of the patient and experience of the responsible intensivist and surgeon. The life saving application of endotracheal suture in a disastrous situation is demonstrated in this report. We present the case of a 83-year-old woman who presented with an acute abdomen and septicaemia. A heavy aspiration occured during in...

 Open Access DOI:10.23937/2377-4630/1/3/1014

Need of Ultrasound in Emergency Department for Suprapubic Catheterization

Prerana N. Shah, Vaishali P Chaskar, Pradeep Rathod, Anand Komawar and Barakha Gadpale

Article Type: Case Report | First Published: November 20, 2014

Acute retention of urine is a medical emergency which needs immediate intervention. Urethral catheterization is a common procedure in the emergency department. Repeated unsuccessful attempts for urethral catheterization demand alternative procedure like suprapubic catheterization. Traditionlly, anatomical landmarks are used to achieve suprapubic catheterization. The confirmation of successful catheterization by ultrasound is recommended. Often due to its unavailability, complications like bowe...

 Open Access DOI:10.23937/2377-3634/1410012

Qualitative Research: A pathway to Gain an Understanding of UAE Mothers' experiences and Perceptions of Managing a Child Newly Diagnosed with Type 1 Diabetes

Jennifer Louise Cooper, Suhad Marjei, Rachel Rossiter and Sharon Brownie

Article Type: Research Article | First Published: November 25, 2014

A childhood diagnosis of Type 1 diabetes is a life changing event for both the child and his/her family. The impact is experienced strongly by mothers who most frequently fulfil the primary caregiver role for children12 yrs old and younger. Studies which have sought to understand mothers' experiences and perceptions of managing a child newly diagnosed with Type 1 diabetes are mostly questionnaire-based and few, if any, explore the issues within the uniqueness of a Middle-Eastern context. The qua...

 Open Access DOI:10.23937/2378-3001/1/1/1012

Randomised Clinical Trial Comparing the Efficacy of A Gluten-Free Diet Versus A Regular Diet in A Series of Relapsing-Remitting Multiple Sclerosis Patients

Rodrigo L, Hernandez-Lahoz C, Fuentes D, Mauri G, Alvarez N, Vega J and Gonzalez S

Article Type: Original Article | First Published: December 08, 2014

Objectives: To analyse the clinical efficacy of a Gluten-Free Diet (GFD) compared with a Regular Diet (RD) in Relapsing-Remitting Multiple Sclerosis (RRMS) patients. Methods: Seventy-two RRMS patients were included into a prospective study. Annual relapse rate (ARR), Expanded Disability Status Scale (EDSS) and lesional activity were compared. Patients were randomly separated according to diet: (GFD, n=36) and (RD, n=36). Follow-up study period was 5.3 ± 1.6 years (median 4.5 years). Results:...

 Open Access DOI:10.23937/2378-3001/1/1/1011

D-Leucine Suppresses Prion Formation in Prion-Infected Culture Cells

Kana Miyashita, Morika Suzuki, Kana Nishijima and Naomi Hachiya

Article Type: Short Communication | First Published: November 24, 2014

Prion disease is an infectious and fatal disease. The pathogen consists of an abnormal form of the prion protein; designated PrPSc. PrPSc is insoluble, highly resistant to digestion by proteases and all disinfectants. In contrast, the cellular form of prion protein PrPC is easily soluble and digested by proteases. Direct interaction between PrPSc and PrPC is believed to induce the propagation of prions; however, the molecular mechanisms underlying this step have not been clarified. Despite effor...

 Open Access DOI:10.23937/2378-3648/1410007

Variation H452Y in HTR2A Gene Effects Immediate Visual Memory

Nesli Avgan, Heidi G. Sutherland, Lauren K. Spriggens, Astrid J. Rodriguez-Acevedo, Larisa M. Haupt, David H. K. Shum and Lyn R. Griffihs

Article Type: Research Article | First Published: November 12, 2014

Serotonin and its receptors, including the 5-Hydroxytryptamine Receptor 2A encoded by the HTR2A gene, are important for learning and memory in animals and humans.Polymorphic variation in the HTR2A gene, which encodes the 5-HT2Aserotonin receptor, has previously been shown to associate with some memory traits,in particular effecting delayed verbal memory. In the current study we have examined the HTR2A His452Tyr (H452Y) substitution for association in a cohort of healthy individuals whose memory ...

 Open Access DOI:10.23937/2469-567X/1510003

Modification of Antiretroviral Therapy in a Cohort Study of HIV-Infected Patients Attending an Urban Teaching Hospital in Kenya

AO Owuor, GN Lule, CF Otieno, EO Omonge, MC Maritim and P Memiah

Article Type: Research Article | First Published: November 28, 2014

Objective: To determine the prevalence and factors associated with ART modification among HIV patients on 1st line therapy attending a large Teaching Hospital in Kenya. Methods: A retrospective cross-sectional clinical record review. All patients who commenced ART from January 2005 to June 2011 and had at least 1 follow-up visit were evaluated. Baseline data, including socio demographic and clinical variables was collected using a standard chart abstraction tool. Results: Out of 1,022 patien...

 Open Access DOI:10.23937/2469-567X/1510002

Prognostic Value of Some Acute Phase Reactants in the Management of Pulmonary Tuberculosis Disease

Akpotuzor Josephine O, Ekarika Evelyn A and Akwiwu Euphoria C

Article Type: Research Article | First Published: November 16, 2014

This study was conducted to assess the relevance of serum C- reactive protein (CRP), erythrocyte sedimentation rate (ESR), relative plasma viscosity (RPV) and fibrinogen level in the management of pulmonary tuberculosis (PTB) disease. One hundred (100) PTB patients attending the TB clinic of Dr Lawrence Henshaw Memorial Specialist Hospital Calabar, and 70 age and sex-matched apparently healthy subjects between 15-65 years of age were selected and enrolled. Standard techniques were used for the a...

 Open Access DOI:10.23937/2378-3648/1410006

Identification of Ten Novel Mutations in Factor VIII Gene: A Study of A Cohort of 52 Haemophilia A Patients

Rosa Santacroce, Angelica Leccese, Roberta Trunzo, Giuseppe Lassandro, Paola Giordano, Cosimo Ettorre, Stefano Antoncecchi, Isabella Cantori, Alfredo Dragani, Donata Belvini, Roberta Salviato and Maurizio Margaglione

Article Type: Research Article | First Published: October 14, 2014

Introduction: Haemophilia A (HA) is the most common X-linked recessive genetic disease caused by mutations in the gene coding for coagulation factor VIII (FVIII) resulting in spontaneous bleeding. Aim: The aim of our study is to provide additional information about the genetic causes of HA describing the correlation between the observed mutations and the clinical phenotype in a cohort of 52 patients suffering from HA to different degrees. Methods: First we performed a search of inversion 22 ...

 Open Access DOI:10.23937/2377-4630/1/3/1013

Allergy to General Anesthetics: Evaluation of Patients Profile

Carla Irani, C. Saade, C. Dagher and P.Yazbeck

Article Type: Original Article | First Published: November 02, 2014

8 millions procedures requiring anesthesia are performed yearly in France with 75% of them being general anesthesia. In 45% of those procedures, a NMBA (neuromuscular blocking agents) is used. Th incidence of allergy to general anesthetics ranges between 1/20000 in Australia and 1/350 in Great-Britain. Th incidence of peranesthestic allergic reactions estimated in 1996 in France was 1/9000, all drugs confounded and the incidence of allergic reactions to NMBA was evaluated to be 1/6500 anesthesia...