Open Access DOI:10.23937/2469-5696/1410011
Hemolytic Anemia in Alcohol-Induced Liver Disease: A Case Report on Zieve's Syndrome
Shefali Nath and Joshua R Peck
Article Type: Case Report | First Published: March 26, 2015
We report a case of Zieve's syndrome in a patient with a longstanding history of alcohol abuse admitted for acute alcoholic hepatitis. Zieve's syndrome is defied as the triad of hemolytic anemia, hypertriglyceridemia, and jaundice in patients with known liver disease. It is an uncommon diagnosis, but is an important one to consider in patients with known liver disease admitted with these constellation of signs and symptoms....
Open Access DOI:10.23937/2378-3648/1410013
Application of Synthetic Standard Curves for Absolute Quantification of Hepatitis A and E by Real-Time PCR
Renata Santos Tourinho, Camilla Rodrigues de Almeida, Andreza Salvio Lemos, Noemi Rovaris Gardinali, Yasmine Rangel Vieira, Jonas Schmidt-Chanasit and Vanessa Salete de Paula
Article Type: Short Communication | First Published: March 23, 2015
Hepatitis A, which presents a major health problem globally, is caused by hepatitis A virus (HAV). This virus, whose primary site of replication is the liver, is the most common agent causing acute liver disease worldwide. Hepatitis E virus (HEV) is the most recently discovered of the hepatotropic viruses, its genome having been identified in 1991. Despite the similarity with hepatitis A virus in their pathogenesis and transmission form, HEV has a zoonotic potential....
Open Access DOI:10.23937/2469-5734/1510005
Ethical Issues in Oral Sciences
Liliane Lins
Article Type: Short Communication | First Published: March 26, 2015
The pressure for scientific production, the allowances of the modern cybernetic world, and insufficient ethical research training of researchers have led to an increasing number of retractions, including in the area of oral sciences. In 2006, a famous oncologist admitted that he had falsified data in three published papers; consequently, he was investigated for other misconduct in science....
Open Access DOI:10.23937/2469-5807/1510002
Clinical Applications of Leukocyte Morphological Parameters
Dongsheng Xu
Article Type: Review Article | First Published: March 25, 2015
Leukocyte morphological parameters, also known as cell population data (CPD), are measured by Coulter automated hematology analyzers with VCS technology. In recent years, clinical applications of CPD have been extensively investigated. The studies have demonstrated that diagnostic utility of neutrophil CPD in acute bacterial infection, particularly their roles in differentiating post-surgical bacterial infection versus systemic inflammatory response syndrome. ...
Open Access DOI:10.23937/2469-5696/1410010
Lenalidomide in patients with Relapsed or Refractory HTLV-1 Related Adult T cell Leukemia/Lymphoma (ATLL)
Adrienne A. Phillips, Jalanni Giddings, Shing M. Lee and Steven M. Horwitz
Article Type: Case Report | First Published: March 21, 2015
Adult T-cell Leukemia/Lymphoma (ATLL) is resistant to chemotherapy and the acute and lymphomatous subtypes of disease have a dismal prognosis. There is no standard therapy for relapsed or refractory disease in Western countries and new agents are being explored. Lenalidomide is an immunomodulatory agent with promising activity in hematologic malignancies, including non-Hodgkin's lymphoma and represents a novel therapeutic option. ...
Open Access DOI:10.23937/2378-2951/1410025
Functional Mitral Regurgitation Tenting Area is Directly Related to Non-Ischemic Cadiomyopathy
Ovidio A. Garcia-Villarreal
Article Type: Letter to the Editor | First Published: March 22, 2015
I have read with great interest the article by Kammoun et al., and I congratulate them for this paper. Functional mitral regurgitation (MR) is a very hard-to-treat illness, because it is not a disease itself but just the final result of an impaired and/or geometrically distorted left ventricle. Agricola et al. have described in a fie way the high impact played by the tethering mechanism of the posterior mitral complex in this kind of patients....
Open Access DOI:10.23937/2378-3001/2/1/1024
Current Pharmacotherapy Strategies and Considerations for the Cognitive Dysfunction Associated with Schizophrenia: A Mini Review
Hikaru Hori, Reiji Yoshimura, Asuka Katsuki, Kiyokazu Atake and Jun Nakamura
Article Type: Mini Review | First Published: March 19, 2015
Cognitive dysfunction associated with schizophrenia is a core symptom that is strongly related to functional levels. In fact, cognitive dysfunction in patients with schizophrenia is due to a combination of the cognitive impairment induced by schizophrenia itself and that induced by the medications that psychiatrists prescribe. It is difficult to differentiate between the two sources, and at present, no medications have a large effect size in terms of improving the cognitive dysfunction induced b...
Open Access DOI:10.23937/2378-3656/1410023
Experimental Use of Transcranial Magnetic Stimulation (TMS) to Treat Tinnitus in a Deaf Patient
Sarah M. Theodoroff and Robert L. Folmer
Article Type: Research Article | First Published: March 24, 2015
A 28-year-old deaf female patient underwent 10 sessions of repetitive Transcranial Magnetic Stimulation (rTMS) as a participant in a placebo-controlled clinical trial for treatment of tinnitus. Trial participants received 2000 pulses of rTMS per session at a stimulation rate of 1 Hz. The neural target for rTMS was auditory cortex within Heschl's gyrus. The primary outcome measure was the Tinnitus Functional Index (TFI); secondary outcome measures included a Visual Numeric Scale (VNS) for selfrat...