Open Access DOI:10.23937/2378-3672/1410009

The Challenge of Eosinophilic Esophagitis

Jeremiah Levine

Article Type: Opinion | First Published: April 03, 2015

Eosinophilic esophagitis (EoE) is a chronic immune-mediated disorder characterized by eosinophilic inflammation of the esophagus. Although the underlying etiology is unknown, EoE is thought to be a TH2 response to environmental allergens in a genetically predisposed individual....

 Open Access DOI:10.23937/2378-346X/1410019

Treatment of Orbital IgG4-Related Disease

Rachel Lee, Craig A MacKinnon, Neil Aburn and Swee T Tan

Article Type: Review Article | First Published: March 31, 2015

Corticosteroids are currently the mainstay treatment for IRD but are associated with adverse side effects, recurrence on discontinuation of medication, and limited response if significant fibrosis is already present. Pentoxyphylline (POF) and α-tocopherol (AT) are anti-inflammatory and anti-fibrosing agents that can be effective in treating both the acute inflammatory and chronic firosclerosing components of IRD....

 Open Access DOI:10.23937/2378-3656/1410027

Clinical Test of Pyrroles: Usefulness and Association with Other Biochemical Markers

Nina Mikirova

Article Type: Clinical Study | First Published: April 03, 2015

Psychiatrists started using urine pyrroles (hydroxyhemopyrrolin-2-one, HPL) to diagnose mental disorders many years ago. The biological origins of HPL are not known, nor are the causes of elevated urinary pyrrole excretion well understood....

 Open Access DOI:10.23937/2469-567X/1510007

Monocyte-Derived Dendritic Cells from Feline Immunodeficiency Virus Positive Cats are Productively Infected and Maintain CD8+ T Cell Stimulatory Capacity

Hood SF, Thompson EM, Akaronu NO, Miller MM and Fogle JE

Article Type: Research Article | First Published: April 03, 2015

Dendritic cells (DCs) have been utilized to enhance CD8+ T cell responses to pathogen-associated peptides for enhancement of vaccine efficacy. CD8+ T cells play a central role in the elimination of viruses during acute viral infection and control of viremia during chronic viral infection. For lentiviral infections such as HIV and FIV, dendritic cell vaccines may be useful for augmenting CD8+ T cell function....

 Open Access DOI:10.23937/2469-570X/1410006

Mechanical Loading Promoted Discogenic Differentiation of Human Mesenchymal Stem Cells Incorporated in 3D-PEG Scaffolds with rhGDF5 and RGD

S. Guggisberg, L. M. Benneker, M. J. Keel and B. Gantenbein

Article Type: Research Article | First Published: March 28, 2015

Synthesized polyethyleneglycol (PEG) hydrogels are appealing with regard to potential for cell therapy or as vehicles for drug delivery or even to regenerate tissue with similar hydrogel-like properties such as the nucleus pulposus of the intervertebral disc (IVD)....

 Open Access DOI:10.23937/2378-3672/1410008

Identifying Toll-Like Receptor Expression in Molluscum Contagiosum

Maria Yaldo, Katherine Caretti, Jessica Kado and Darius R Mehregan

Article Type: Research Article | First Published: March 31, 2015

Toll-like receptors (TLRs) are known to be involved in the immunogenic response in a variety of dermatological disorders including psoriasis, condyloma acuminata, atopic dermatitis, and cutaneous T-cell lymphoma. However, the expression of TLRs in Molluscum contagiosum has not yet been clearly defied.Expression of TLRs 1-9 was examined in molluscum by immunohistochemical staining....

 Open Access DOI:10.23937/2378-3656/1410026

Paediatric Hodgkin Lymphoma and Radiation Therapy: 3DCRT vs VMAT. A Case Report

Annalisa Nardone, Leonarda Rella, Anna Milella, Antonio Pascali, Pasquale Tamborra, Michele Telegrafo and Marco Lioce

Article Type: Case Report | First Published: April 02, 2015

Hodgkin Lymphoma (HL) is one of the most common cancers in young adult. Early stage Hodgkin disease has a good prognosis and high survival rates with modern therapeutic approaches. Clinical management of early stage HL involves two therapeutic options: one is combined modality therapy with abbreviated chemotherapy plus involved field radiation therapy (IFRT) and the other is chemotherapy alone....

 Open Access DOI:10.23937/2377-9004/1410029

Preventing E. coli O157:H7 Infection in Pregnancy

Bharati Kalgi and Mark G Martens

Article Type: Review Article | First Published: March 29, 2015

E. coli O:157 causes 73,000 illness in the United States annually. It is estimated that up to 10% of patients with EHEC infections may develop HUS, with a case-fatality rate ranging from 3% to 5%. Overall, HUS is the most common cause of acute renal failure leading to chronic renal sequelae in approximately 50% of survivors....

 Open Access DOI:10.23937/2378-346X/1410018

Artisan versus ICL in the same Patient: A Slight Aberration Makes a Big Difference

Isabel Signes-Soler, Tomas Moya Callejo, Jesus Gimeno Piza and Jaime Javoloy Estan

Article Type: Case Report | First Published: March 31, 2015

We report the case of a 30-year-old woman implanted with an irisfixated lens (Artisan, OPHTEC) in the right eye (RE) and with an implantable contact lens (ICL) (V4, STAAR) the left eye (LE) for the correction of high myopia. The patient complained of halos and distortion on the RE 4 years after the Artisan implantation. There was a slight superior descentration of the phakic IOL....

 Open Access DOI:10.23937/2469-5696/1410012

The Comparison between Microhematocrit and Automated Methods for Hematocrit Determination

Gebrewahd Gebretsadkan, Kebede Tessema, Henock Ambachew and Misganaw Birhaneselassie

Article Type: Research Article | First Published: April 01, 2015

Hematocrit is a test that measures a percentage of blood that is comprised of red blood cell. This is often referred to as packed cell volume (PCV) or erythrocyte volume fraction. It is considered as an integral part of a person's complete blood count, along with hemoglobin concentration, white blood cell count and platelet counts....