Open Access DOI:10.23937/2469-5718/1510003

Characterization of Endorphin Gene Expression Following Electroporation in Mice Tibialis Anterior Muscle: Implications for Gene Doping Detection

Morten Klitgaard Nohr, Parisa Gazerani, Julie Gehl3 and Jacek Lichota

Article Type: Research Article | First Published: April 13, 2015

Since ancient time, doping has been used by athletes. The prevalence for using performance-enhancing agents is increasing and new methods are being applied. Gene doping is foreseen to become one of the new doping methods in athletic performances. This study was therefore performed to investigate the possibility of transfecting a gene encoding the endogenous peptide preproenkephalin (PENK) in mice as gene doping candidate and subsequently establish a functional detection method....

 Open Access DOI:10.23937/2469-5769/1510004

A New Outlook on Clinical Course of Juvenile Dermatomyositis - Experience of a Single Center

Krzysztof Orczyk, Joanna Swidrowska, Jerzy Stanczyk and Elzbieta Smolewska

Article Type: Research Article | First Published: April 08, 2015

Juvenile dermatomyositis (JDM) is the most common inflammatory myopathy in children. Diagnostic criteria by Bohan & Peter are originally formulated for adults. A wide range of differences in clinical course of dermatomyositis between adults and children has provoked to set a new look at the existing criteria....

 Open Access DOI:10.23937/2377-9004/1410032

Blasts on Blood Film after Treatment of Ovarian Cancer

Heong V, Duong B and Wong S

Article Type: Case Report | First Published: April 13, 2015

A 40 year old female with a history of hypertension, depression and menorrhagia was admitted with a one week history of flu like symptoms, lethargy and neutropenia. Two years prior to admission, she was diagnosed with FIGO Stage IIC clear cell epithelial ovarian cancer and underwent a total abdominal hysterectomy and bilateral salphingo-oophorectomy (optimal debulking)....

 Open Access DOI:10.23937/2378-2951/1410026

Association between Syncope and Myocardial Bridge

Lins TCB, Valente LM, Oliveira KTMN and Brandao SCS

Article Type: Case Report | First Published: April 10, 2015

Myocardial bridge is a cause of sudden death in athletes, but syncope is somewhat related to this disease symptom. This paper reports a case of a young athlete, swimming practitioner with syncopal episodes related to physical exertion....

 Open Access DOI:10.23937/2378-3419/2/2/1016

The Shortage of Essential Cancer Drugs and Generics in the United States of America. Global Brain Storming Directions for the World.

Ahmed Elzawawy

Article Type: Research Article | First Published: April 15, 2015

The shortage of the older essential cancer drugs that are off patent, mostly generics and injectable, has its threatening impact on health of cancer patients, clinical trials and the burden of costs spending on the health system in the United Sates. The problem is multifactorial and mostly economical and due to lack of incentives for production....

 Open Access DOI:10.23937/2469-570X/1410007

Enhancement of Human Adipose-Derived Stem Cell Expansion and Stability for Clinical use

Swenn Maxence Krähenbuhl, Anthony Grognuz, Murielle Michetti, Wassim Raffoul and Lee Ann Applegate

Article Type: Research Article | First Published: April 06, 2015

Co-culture techniques associating both dermal firoblasts and epidermal keratinocytes have shown to have better clinical outcome than keratinocyte culture alone for the treatment of severe burns. Since fat grafting has been shown to improve scar remodelling, new techniques such as cell-therapy-assisted surgical reconstruction with isolated and expanded autologous adipose-derived stem cells (ASCs) would be of benefit to increase graft acceptation....

 Open Access DOI:10.23937/2469-5769/1510003

Short Lingual Frenulum and Obstructive Sleep Apnea in Children

Yu-Shu Huang, Stacey Quo, J Andrew Berkowski and Christian Guilleminault

Article Type: Research Article | First Published: April 08, 2015

A retrospective study of prepubertal children referred for suspicion of obstructive sleep apnea, found 27 subjects with non-syndromic short lingual frenulum. The children had findings associated with enlarged adenotonsils and/or orofacial growth changes....

 Open Access DOI:10.23937/2378-3001/2/1/1027

Marburg's Variant of Multiple Sclerosis with Extensive Brain Lesions: An Autopsy Case Report

Ayumi Ludwig, Jaclyn Duvall, Jo Elle Peterson and Ryan Hakimi

Article Type: Case Report | First Published: April 10, 2015

Marburg's variant of multiple sclerosis (MS) is a malignant and rapidly progressive form of MS that typically leads to deterioration or death within weeks to months. Here we present a case involving a 25-year-old woman who presented with fluctuating mild encephalopathy of one-week duration who progressed to coma and ultimately died on day seven after being admitted to our university based neurosciences intensive care unit (NSICU)....

 Open Access DOI:10.23937/2378-3001/2/1/1026

Atypical Antipsychotic Drugs in Dual Diagnosis Patients: A Review

Marta Marin-Mayor, Jorge Lopez-Alvarez, Francisco Lopez-Munoz, Francisco AriasHorcajadas and Gabriel Rubio

Article Type: Review Article | First Published: March 30, 2015

Dual Diagnosis (DD), defined as the co-occurrence of a Substance Use Disorder (SUD) and a Severe Mental Illness (SMI), is associated with several negative outcomes. Typical antipsychotics (TAP) are not of great value for patients with DD as they are associated with poorer responses and can worsen SUD. Atypical antipsychotics (AAP) offer several advantages compared to TAP....

 Open Access DOI:10.23937/2469-5726/1510008

Osteoimmunological Aspects on Inflammation and Bone Metabolism

Uwe Lange, Gabriel Dischereit, Elena Neumann, Klaus Frommer, Ingo H. Tarner and Ulf Muller-Ladner Kerckhoff-Klinik

Article Type: Review Article | First Published: April 09, 2015

Bone remodelling is characterized by a balance between bone resorption and bone formation. The osteoblasts are responsible for bone synthesis and the osteoclasts for bone resorption. A finely adjusted interaction between molecular mechanisms results, via cytokines, hormones and growth factors, in homeostasis of bone metabolism....