Open Access DOI:10.23937/2572-407X.1510001
Energy Intake, Dietary Habits and Life Style in Obese School Children with Dyslipidemia in the UAE
Asma Deeb, Rawan Al Hazaimeh, Salima Attia, Abubaker ElFatih, Omar Afandi and Nico Nagelkerke
Article Type: Original Article | First Published: May 28, 2015
The incidence of obesity in children is increasing. In the United Arab Emirates (UAE), childhood overweight and obesity reached up to 25% of the population. In addition, UAE has become one of the highest countries in the prevalence of type 2 diabetes. Various forms of life style behavior and dietary habits have contributed to obesity and the development of the metabolic syndrome. We aim to study energy intake, dietary habits and life style behavior in obese children with dyslipidemia in the UAE ...
Open Access DOI:10.23937/2378-2951/1410033
On the Logic of Percutaneous Coronary Interventions
P. Lanzer and P. Wang
Article Type: Logical Study | First Published: May 30, 2015
Performance of percutaneous coronary interventions (PCI) is largely based on empirical experience of individual operators. Due to the perceived mostly intuitive character to date little data concerning formal and reasoning structure of PCI is available. Non-axiomatic logic (NAL) provides consistent format allowing systematic analysis of reasoning applicable to PCI. In this report we introduce the basic principles of NAL and provide relevant introductory examples representing clinical reasoning i...
Open Access DOI:10.23937/2378-2951/1410032
Can a Genetic Test Predict the Development of Postoperative Atrial Fibrillation
Gurpreet Sodhi, Jennifer Shea, Farzad Najam and Allen J Solomon
Article Type: Research Article | First Published: May 26, 2015
Atrial fibrillation (AF) is the most common postoperative complication of cardiovascular surgery. In large cohorts, genetic variants in the 4q25 chromosome region have been associated with postoperative AF. However, the role of genetic testing in an individual patient to predict the development of AF has been understudied....
Open Access DOI:10.23937/2469-5750/1510003
Exogenous Ochronosis with Use of Low Potency Hydroquinone in A Caucasian Patient
Luke Maxfield and David A. Gaston
Article Type: Case Report | First Published: May 30, 2015
Exogenous ochronosis is a rare condition of paradoxical skin darkening seen with use of the skin lightening agent hydroquinone. Incidence has been highest in patients with darker skin types, prolonged use, and higher concentration treatment, but has been reported with low dose (2%) as well. Here we present a rare case of exogenous ochronosis, with resultant skin and nail hyperpigmentation, occurring in a Caucasian female using 3% hydroquinone cream over an eighteen-month period....
Open Access DOI:10.23937/2469-5718/1510010
A New View of Responses to First-Time Barefoot Running
Michael Wilkinson, Nick Caplan, Richard Akenhead and Philip R Hayes
Article Type: Original Investigation | First Published: May 28, 2015
We examined acute alterations in gait and oxygen cost from shod to-barefoot running in habitually-shod well-trained runners with no prior experience of running barefoot. Thirteen runners completed six-minute treadmill runs shod and barefoot on separate days at a mean speed of 12.5km.h-1. Steady-state oxygen cost in the final minute was recorded. Kinematic data were captured from 30-consecutive strides. Mean differences between conditions were estimated with 90% confidence intervals....
Open Access DOI:10.23937/2469-5718/1510009
Eccentric Loading Increases Peak Torque Angle of the Ankle Plantar Flexors in Healthy Volunteers
Matthew Wellisch, Peter Hamer, Luke Hopper, Max Bulsara and James Debenham
Article Type: Original Research | First Published: May 24, 2015
Eccentric loading of the ankle plantar Flexor's (PF) has demonstrated clinical efficacy in the conservative treatment of Achilles tendinopathy, however, its mechanism of therapeutic benefit remains unclear. The purpose of this study was to examine the effects of PF eccentric loading on PF angle to peak torque (AtPT), peak torque (PT) and lower limb vertical stiffness. Thirty healthy volunteers were randomised to an eccentric (n=15) or concentric (n=13) exercise group....
Open Access DOI:10.23937/2469-5718/1510008
Exercise and Stem Cell Therapeutics for the Infarcted Heart
Joseph R Libonati
Article Type: Commentary | First Published: May 18, 2015
Heart failure afflicts 5.1 million individuals in the United States and its prevalence is expected to increase 25% by 2030. It is associated with a poor quality of life, increased mortality, and is extremely expensive to health care systems. The progressive loss of cardiomyocytes is a central feature of heart failure from multiple etiologies....
Open Access DOI:10.23937/2378-3419/2/2/1017
Hepatic Cancer Stem Cells and Signaling Pathways
Mohammad Khalid Zakaria, Ashraf Ali, Kaneez Fatima, Mohd Suhail, Shilu Mathew, Saleh Alkarim, Esam Azhar and Ishtiaq Qadri
Article Type: Review Article | First Published: April 30, 2015
Loss of hepatocytes due to infection, inflammation or partial hepectomy simulates a response which helps in the liver restoration. This maintains homeostasis and keeps a check on the usual wear and tear in the liver. Cancer stem cells (CSCs) were demonstrated to be associated with myeloid leukemia. However, with recent advancements in the approaches and techniques, CSCs are also present within a wide variety of solid tumors and malignancies of epithelial origin....
Open Access DOI:10.23937/2469-567X/1510008
Liver Fibrosis in HIV and HCV Co-Infection: Independent Mechanisms versus Collective Efforts
Jose D Debes, Paul R Bohjanen and Andre Boonstra
Article Type: Review Article | First Published: May 27, 2015
Liver disease is the leading cause of death not related to AIDS in patients infected with human Immunodeficiency Virus (HIV). Patients co-infected with HIV and hepatitis C virus (HCV) experience a more rapid progression liver to fibrosis and develop hepatocellular carcinoma at a younger age than those infected with either virus alone. The mechanisms promoting this accelerated progression to fibrosis are not totally understood. Moreover, it is unclear whether both viruses exert fibrosis progressi...