Open Access DOI:10.23937/2469-584X/1510001
Expectations for Hepatitis B Universal Vaccination for Hepatitis B Virus Eradication
Toru Ishikawa
Article Type: Review Article | First Published: August 26, 2015
The incidence of hepatitis B virus (HBV)-related HCC has not declined for the past several decades. HBV is essentially a disease that could potentially be eradicated by a vaccine. According to the World Health Organization (WHO), two billion people (one-third of the global population) have been infected with HBV worldwide, and more than 240 million are chronic carriers (4-6% of the world population)....
Open Access DOI:10.23937/2377-4630/2/3/1033
Safety and Efficacy of Remifentanil for Single Agent Procedural Sedation: A Systematic Review
Jeppe T Jensen, Peter Vilmann, Lars Konge and Moller
Article Type: Review Article | First Published: August 19, 2015
Hospitals and healthcare centers are continuously pushed to deliver a better quality of care with a higher turnover. Hence, there is an increasing demand for shorter procedures and shorter time to discharge. Some of these requirements can be met if sedation is used instead of general anesthesia. Furthermore, sedation, as an alternative to nothing, has its benefits. Two recent studies have shown that sedation for endoscopies increases endoscopist satisfaction, the patient's willingness to undergo...
Open Access DOI:10.23937/2377-4630/2/3/1032
The Effects of High-Dose Sugammadex on Erythrocyte Deformability in Rats with Renal Failure Generated by Unilateral Ureteral Obstruction
Fusun Bozkirli, Fikriye Dogrul, Faruk Metin Comu, Hande Arpaci, Omer Bayrak, Mustafa Arslan and Yusuf unal
Article Type: Original Article | First Published: August 18, 2015
One of the most common causes of renal insufficiency in children and adults is obstructive nephropathy. Unilateral ureteral obstruction (UUO) is a well-known model to imitate the obstructive nephropathy process in a simple, accelerated and species-independent manner. Previous studies have revealed that morphological lesions in the obstructed kidney are peritubular capillaries rarefaction, tubular atrophy, inflammatory infiltration, widen interstitial space, and progressive tubulointerstitial fib...
Open Access DOI:10.23937/2469-5718/1510019
Severe Musculoskeletal Injuries due to the use of Cleats Whilst Cycling
J Kukadia, G Zamfir, G Arealis, N Ashwood and B Karagkevrekis
Article Type: Case Series | First Published: September 4, 2015
In cycling, pedalling symmetry and foot position is paramount for an energy efficient and injury free ride. Traditionally a clipped pedal was used to secure the foot onto the pedal, which was found to be related to a number of overuse knee injuries, leading to the advent of clipless pedals or cleats, which allowed for a more efficient pedal stroke. Whilst there is some research behind cleat design in football, little remains for cycling. Here we present a series of five patients with severe trau...
Open Access DOI:10.23937/2469-5718/1510018
Glyceryl Trinitrate Patches: A Modern Treatment for Tendinopathies
Yusuf Assem and Manit Arora
Article Type: Commentary | First Published: August 23, 2015
Tendinopathy encompasses a variety of conditions that develop within tendons in response to overuse, characterized by pain and dysfunction. These include disorders of the Achilles tendon, patellar tendon, lateral epicondyle, medial epicondyle and the rotator cuff. Historically, most of these disorders have been attributed to tendinitis or inflammation of the tendon, however recent histopathological work has lent support to tendinosis as the underlying pathology....
Open Access DOI:10.23937/2469-5734/1510014
Doxycycline and Coenzyme Q10 Treatment Modalities for Chronic Periodontitis: A Preliminary Study
Mahmoud Darweesh, Hesham El-Sharkawy, Omar N Fadhil and Ola M Maria
Article Type: Research Article | First Published: August 13, 2015
Periodontal diseases are inflammatory disorders that affect 10-15% of the population worldwide and represent one of the major causes of tooth loss. Such diseases result from complex interactions between periodontal pathogens and the host immune response. Owing to the high prevalence, scientists have been attracted to research aimed to treat periodontal diseases; however, treatments are always challenging. Conventional treatment of periodontitis focused on reducing the pathogens by standard scali...
Open Access DOI:10.23937/2469-5734/1510013
Effects of Different Curing Unites on Bulk Fill Composites
Koray Soygun, Murat Unal, Ali Ozer, Evrem Gulnahar and Giray Bolayir
Article Type: Research Article | First Published: August 09, 2015
The aim of this study was to investigate three aged (with thermocycling and distilled water) bulk fill composites' (X-tra base, Surefil SDR flow, Tetric EvoCeram) surface microhardness levels. 4mm diameter and 2 or 4mm thickness composites' samples were polymerized by a halogen light and a blue-light emitting diode (n = 10). A Vickers microhardness tester was used to evaluate the microhardness at the top and bottom surfaces of every specimen. When the measurements of bottom parts were evaluated,...
Open Access DOI:10.23937/2469-5734/1510012
Kissing Molars: A Report of Three Cases and Literature Review
Luis Miguel Gonzalez-Perez, Pedro Infante-Cossio, Marta Sanchez-Sanchez, Carlos Valdivieso-del-Pueblo and Marta Robles-Garcia
Article Type: Case Report | First Published: August 07, 2015
The existence of two mandibular impacted molars with confronted occlusal surfaces is extremely rare. When the two mandibular molars are surrounded by a single dental follicle, an entity called 'kissing molars' (KM) is formed. After the first description of KM by Van Hoof in 1973, very few cases have been reported in the literature. Therefore, knowledge about the etiopathogenesis, clinical features, and diagnostic and therapeutic options for KM is limited. The present study is based on a literatu...
Open Access DOI:10.23937/2378-3419/2/3/1021
A Randomized Double Blinded Study of Ganoderma Lucidum (Lingzhi) in Salvage Setting of Recurrent Gynecologic Cancer
Prapaporn Suprasert, Chatchawann Apichartpiyakul, Choompone Sakonwasun, Pimonphan Nitisuwanraksa and Rochana Phuackchantuck
Article Type: Research Article | First Published: August 28, 2015
Lingzhi is a widely used anti-cancer herbal medicine in Asian countries with limited knowledge of the efficacy especially in gynecologic cancer patients. This study was conducted to compare the efficacy of Lingzhi in the forms of water extract type and spore type with a placebo control in a salvage setting of gynecologic cancer treatment. Sixty gynecologic cancer patients who failed at least two regimens of chemotherapy were randomly divided equally to ingest 6000 mg/day of Lingzhi in form of wa...