Open Access DOI:10.23937/2469-5750/1510004
Vancomycin Hypersensitivity Reaction Presenting with Extensive Oral Ulcerations
Justin G. Hastings, Alok Vij and Anthony P. Fernandez
Article Type: Case Report | First Published: August 15, 2015
Vancomycin therapy is associated with several hypersensitivity reactions, the most common being the non-immunologically mediated 'red man syndrome'. Fever, rash, neutropenia, and other manifestations have also been variably associated with a vancomycin hypersensitivity reaction that is likely immunologically mediated. Here we report a 45-year old man who developed diffuse oral aphthous-like ulcers as the most prominent manifestation of vancomycin hypersensitivity reaction. We identified only two...
Open Access DOI:10.23937/2378-346X/1410035
Introduction of Basic and Advanced Techniques of Ophthalmic Surgery in Myanmar
Carl-Ludwig Schonfeld, Chaw Wai Lwin, Volker Klaub, San Hlaing, Thazin Shwe, Mya Thandar So, San Myint, Claudia Klaub, Tomas Schaal, Martin Gruterich and Tin Win
Article Type: Research Article | First Published: September 01, 2015
Purpose: We report our fist experience with the introduction of an external teaching programme in Myanmar, a country that has only recently opened to the rest of the world. Methods: 19 eyes in 18 patients were treated by surgical teams comprising a German senior surgeon and a local ophthalmologist. Diagnoses and treatment procedures were recorded, and visual acuity was measured before and 1-7 days after surgery....
Open Access DOI:10.23937/2378-346X/1410033
Inflammation and Oxidative Stress in Retinal Diseases: The Role of Intracellular Signaling in the Retinal Pigment Epithelium
Melina V. Mateos, Paula E. Tenconi, Norma M. Giusto and Gabriela A. Salvador
Article Type: Review Article | First Published: August 23, 2015
Inflammation and oxidative stress (OS) are common factors involved in the pathogenesis of several retinal diseases that eventually end in vision loss and blindness, such as age-related macular degeneration (AMD), diabetic retinopathy (DR), retinitis pigmentosa and uveitis. Most of the studies on the above mentioned diseases have been focused on the neural retina. However, in view of the importance of the retinal pigment epithelium (RPE) in the maintenance of photoreceptors' (PR) viability and vi...
Open Access DOI:10.23937/2378-3001/2/2/1031
Corpora Amylacea in Neurodegenerative Diseases: Cause or Effect?
Troy T. Rohn
Article Type: Review Article | First Published: August 28, 2015
The presence of corpora amylacea (CA) in the CNS is associated with both normal aging and neurodegenerative conditions including Alzheimer's disease (AD) and vascular dementia (VaD). CA are spherical bodies ranging in diameter (10-50 micro meter) and whose origin has been documented to be derived from both neural and glial sources. CA are reported to be primarily composed of glucose polymers, but approximately 4% of the total weight of CA is consistently composed of protein. CA are typically loc...
Open Access DOI:10.23937/2378-3001/2/2/1030
Acute Treatment with Renal Denervation in a Patient with Resistant Hypertension and Hemorrhagic Stroke
Francesco Versaci, Antonio Trivisonno, Luca Brunese and Francesco Prati
Article Type: Case Report | First Published: August 28, 2015
A 49-year-old man with refractory hypertension was admitted to our hospital in a coma caused by hemorrhagic stroke. Severe hypertension was observed during hospitalization despite a full antihypertensive therapy. Considering the risk of enlargement of the intracranial hematoma, the decision was made to perform renal denervation (RDN). A significant blood pressure reduction was obtained after RDN. The patient had a progressive improvement of general conditions and came out of the coma after a few...
Open Access DOI:10.23937/2378-3419/2/3/1020
Reducing Sample Sizes in Phase II Trials based on Exact Binomial Tests by Shifting Design Parameters
Dirk Klingbiel, Qiyu Li and Martin Bigler
Article Type: Research Article | First Published: August 20, 2015
Currently, a large number of new anticancer agents is accompanied by constrained resources, requiring prioritization. In addition, emerging molecular subtypes subdivide common cancer entities into rare diseases, making it harder to conduct phase II trials as a crucial step in drug development and therapy optimization. We extend a recent work by Khan et al. on the design of phase II clinical trial based on exact binomial tests....
Open Access DOI:10.23937/2469-5777/1510005
Primary Total Elbow Arthroplasty in the Treatment of Complex Elbow Fracture: A Case Report
Pedro Miguel Campos, Barbara Rosa, Andre Barros, Carlos Durao, Gloria Magalhaes, Clara Julio and Pedro Quinaz Neto
Article Type: Case Report | First Published: August 01, 2015
A 54-year-old male patient presented at our emergency department in the sequence of a motorcycle accident, which caused an open fracture of the left elbow, classified as type IIIB of Gustilo and Anderson. The X-ray showed comminuted fractures of distal humerus and proximal ulna with bone loss from both epiphysis. He started antibiotherapy and was submitted to immediate surgical debridement, provisional fixation with an external fixator and skin closure. The external fixator was removed 2 months ...
Open Access DOI:10.23937/2469-5718/1510015
Paediatric Hip Pain: A Rare Injury
Raj Subbu and Fares Haddad
Article Type: Case Report | First Published: August 07, 2015
Paediatric hip pain in young athletes can be a diagnostic challenge for clinicians. The anatomy of the paediatric pelvis and surrounding structures varies considerably to that of an adult and therefore is predisposed to different types of injuries which can lead to future deformities if not managed appropriately. Unlike adult pelvic fractures, which have set guidelines and management strategies, less research exists on these injuries in the paediatric context and more specifically in the sportin...