Open Access DOI:10.23937/2378-3656/1410061
A Rare Case of Bilaterale Ureterohydronephrosis due to Cystitis Cystica Et Glandularis and Review of the Literature
Zafer Demirer, Ali Guragac, Burak Kopru, Bilal Firat Alp and Ibrahim Yildirim
Article Type: Case Report | First Published: October 05, 2015
Cystitis Cystica Et Glandularis (CCEG) is a metaplastic lesion of the bladder mucosa with a characteristic histopathologic appearance. CCEG are commonly found in specimens taken from the bladder wall of patients with cancer and other diseases or at autopsy. In most cases the course of CCEG is asymptomatic. Some patients complain of hematuria, symptoms associated with the obstruction of the upper urinary tract, or lower urinary tract symptoms. The main symptoms of CCEG accompanied with upper urin...
Open Access DOI:10.23937/2378-3656/1410060
Untreated Chiari 1 Malformation in Adulthood with Massive Hydrosyringomyelia and Hydrocephalus
Carlo Nicola De Cecco, Davide Bellini, Elisa Porretta, Francesca Cortese, Andrea Laghi and Gianluca Coppola
Article Type: Case Report | First Published: October 1, 2015
We describe a case of untreated Chiari I malformation in adulthood. It is characterized by displacement of the cerebellar tonsils caudally through the foramen magnum, associated with massive hydrosyringomyelia and tetraventricular hydrocephalum. Magnetic Resonance (MR) imaging provides excellent visualization of intracranial and intraspinal malformations, and thus contributes greatly to their correct diagnosis and treatment....
Open Access DOI:10.23937/2378-3656/1410059
Posterior Uterine Wall Rupture of an Unscarred Uterus in a Woman with History of Congenital Diaphragmatic Hernia Repair
Anna Grassi, Benjamin Scott, Dominic Cammarano, Xuezhi Jiang and Peter F Schnatz
Article Type: Case Report | First Published: September 28, 2015
A 24-year-old woman, gravida 5, para 2, with single gestation at 41 weeks and 1 day was admitted to the labor unit with regular uterine contractions. Her obstetrical history was significant for two previous uncomplicated spontaneous vaginal deliveries, one ectopic pregnancy and one missed abortion. Her medical history was unremarkable. Her surgical history was significant for a congenital diaphragmatic hernia repair as an infant and dilation and curettage for missed abortion. During an uneventfu...
Open Access DOI:10.23937/2378-3656/1410058
The Challenge of Infections in Frail Elderly: The Story of Mr. Nilsson
Sund-Levander M and Grodzinsky E
Article Type: Case Report | First Published: September 26, 2015
Signs and symptoms of infection in Nursing Home Residents (NHR) are often atypical with a lack of specific ones, causing a delay in diagnosis and treatment. The complexity of detecting infections in NHR can be explained by difficulties in understanding and interpreting non-specific signs and symptoms and co-existing chronic diseases that blur the clinical picture. The case of Mr. Nilsson illustrates the process from the first signs and symptoms of infection to diagnosis in an elderly person with...
Open Access DOI:10.23937/2378-3419/2/4/1028
Targeting of Myeloid Derived Suppressor Cells Using Anti-inflammatory and Pro-inflammatory Agents
Parvin Forghani and Edmund K Waller
Article Type: Review Article | First Published: October 03, 2015
Myeloid-derived suppressor cells (MDSC) have been considered to be key mediators of immuno-suppression in cancer. The numbers of MDSCs increased in the blood and in the tumor microenvironment during inflammation. Due to the strong correlation between inflammation and cancer that results in tumor progression through MDSCs-associated immune-suppression, it is posited that modulating MDSCs using anti-inflammatory drugs will enhance the activity of immunotherapy and antitumor immunity....
Open Access DOI:10.23937/2378-3419/2/4/1026
Systematic Review and Meta-Analysis to Determine the Optimum Staging modality for Primary Breast Cancer
Berney M, Manning A, Carter M, Sacchini V, Kell M R. Barry M
Article Type: Original Article | First Published: September 24, 2015
Staging of primary breast cancer can radically alter the management if stage IV disease is accurately detected. A systematic review and meta-analysis were performed to determine whether conventional CT TAP or PET-CT provides the optimum staging modality. A meta-analysis involving 158 patients with primary breast cancer showed that PET-CT was more sensitive than CT-TAP for detection of metastatic disease (OR 3.28, 95% CI 2.37 - 4.53, p < 0.0001). A systematic review of 1780 patients undergoing PE...
Open Access DOI:10.23937/2378-3419/2/4/1025
Common Polymorphisms in the USF1 Gene and Cancer Susceptibility: A Meta-Analysis
Meng Zhang, Jian Bai1, Junjie Huang, Yukun Ge, Hu Xiong, Wei Lu, Jizhou Shi, Lu Fang, Song Wu and Zhiming Cai
Article Type: Original Article | First Published: September 21, 2015
Upstream transcription factor 1(USF1) has been identified to be implicated in the development of many cancer categories. In view of recent studies, several polymorphisms in USF1 gene appeared to exert diverse influence on cancer susceptibility. However, the association between USF1 polymorphisms and cancer susceptibility remains inconclusive due to the finite relevant published discoveries. Therefore, we conducted a meta-analysis by pooling all available published data on the susceptibility of U...
Open Access DOI:10.23937/2469-570X/1410011
Potential Immune Modulatory Action of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Type 1 Diabetes
Andrea Carpanetto, Chiara Gai, Enrica Favaro, Maria Maddalena Zanone and Giovanni Camussi
Article Type: Short Review | First Published: September 28, 2015
Several preclinical studies have shown potential immune-modulatory properties of mesenchymal stem cells (MSC) in type 1 diabetes leading to phase I/II clinical trials. Immune-modulatory properties of MSC have been mainly ascribed to their secretome. The extracellular vesicles (EV) have emerged as paracrine mediators of MSC actions. In fact, MSC-derived EV have been shown to carry proteins and nucleic acids capable to mimic the effect of originating cells. In the present short review we discuss e...