Open Access DOI:10.23937/2378-3516/1410030

A Pain in the Neck: A Pott's Disease Case Study

Caitlin Naureckas, Jonathan Movson and E Jane Carter

Article Type: Case Report | First Published: October 20, 2015

A 21-year-old Guatemalan male presented with six months of headaches and neck pain. MRI of the cervical spine demonstrated multiple inflammatory processes, both within the paraspinal soft tissue as well as within the bone itself, including the appearance of total destruction of C1. Microbiologic confirmation of Mycobacterium tuberculosis was made by fine needle aspiration. The patient was treated medically with appropriate anti-tuberculosis therapy coupled with aggressive pain control and carefu...

 Open Access DOI:10.23937/2378-3397/1410029

Congenital Cystic Lung Malformation Presenting in a Previously Asymptomatic Thirty-Year-Old Patient

Alecia Vandevelde

Article Type: Case Report | First Published: October 26, 2015

This case is a rare presentation in an adult in his thirties of an uncommon disease normally detected in utero or shortly thereafter. It posed a diagnostic dilemma for our surgical and medical teams initially. We chose to manage this case surgically and have achieved a good outcome in doing so. The ideal management however is still controversial....

 Open Access DOI:10.23937/2469-570X/1410012

Advantage in Human Induced Pluripotent Stem Cells Research of X-Linked Genetic Diseases for Drug Screening

Takeo Kubota

Article Type: Short Review | First Published: October 22, 2015

Human induced pluripotent stem cell (hiPSC) technology has widely been used for modeling of various genetic diseases. In the disease-modeling iPSC studies, it is necessary to generate hiPSC lines from peripheral tissues of multiple patients and of multiple age- and sex-matched control individuals in order to minimize the differences in genetic background that can affect the results. However, we can generate disease model-hiPSC line with mutant allele being expressing and normal control-hiPSC lin...

 Open Access DOI:10.23937/2378-346X/1410039

Glaucoma Functional Damage and Comparative Psychophysical Studies

Amal A. Elgohary, Laila Hassan M. Elshazly and Iman A. Fahmy

Article Type: Research Article | First Published: September 23, 2015

Many clinical tests have been developed to determine the damage of visual function caused by glaucoma. These tests help in early detection of glaucoma, quantification of glaucomatous damage and progression. Currently, perimetry remains the measure of choice for studies of glaucoma progression. Visual field loss is the most prevalent and characteristic form of visual function loss associated with glaucoma....

 Open Access DOI:10.23937/2378-346X/1410038

Systemic Lupus Erythematosus Presenting as Acute Posterior Multifocal Placoid Pigment Epitheliopathy - Case Report and Review of the Ocular Manifestations of Systemic Lupus Erythematosus

Stephanie Chan and Chloe C. Gottlieb

Article Type: Case Report | First Published: September 11, 2015

The ocular manifestations of systemic lupus erythematosus (SLE) are numerous and may be due to complement-activating immune complex deposition causing inflammation or thrombosis, secondary effects of SLE such as hypertension, related diseases such as Sjogren's and Antiphospholipid antibody syndrome, or a combination of these. Left untreated, these manifestations can result in serious morbidity and rarely, mortality....

 Open Access DOI:10.23937/2378-2951/1410053

Symptomatic Main Coronary Artery Fistula with Stress/Rest Myocardial Perfusion SPET Ischemia

Ramirez-Moreno A and JR. Siles-Rubio

Article Type: Case Report | First Published: September 21, 2015

We report a case of 65-year-old woman who presented sporadic exercise chest pain episodes. The rest ECG, cardiac ultrasound were normal, exercise test shows nonspecific repolarization ECG changes, myocardial Stress/Rest Tc-99m MIBI SPET disclosed a reversible defect in the medial and distal portions of the anterior wall and the apex....

 Open Access DOI:10.23937/2378-2951/1410052

Variable Phenotypic Expression Including Late Presentation of Hypertrophic Cardiomyopathy in LEOPARD Syndrome with P.Q510E Mutation in PTPN11 Gene

Md. Zahidus Sayeed, Md. Abdus Salam, Muhammad Afsar Siddiqui, Pampa Chandra, Joydeep Bhaduri and Zahurul A. Bhuiyan

Article Type: Case Report | First Published: September 17, 2015

LEOPARD syndrome is a complex dysmorphogenetic disorder of variable penetrance and expressivity. Mutations in the PTPN11 gene are frequently reported in patients with Noonan syndrome (NS) and LEOPARD syndrome (LS). Q510E mutation in PTPN11 has always been associated with lethal or rapidly progressive hypertrophic cardiomyopathy both in NS and LS patients. Besides, deafness is also frequently present in these patients, but reproductive fitness is questioned. ...

 Open Access DOI:10.23937/2378-2951/1410051

Preventing Acute Cardiac Events during Marathons with Pre-Race Aspirin

Arthur J. Siegel

Article Type: Review Article | First Published: September 15, 2015

Reducing sudden cardiac death during sport is the highest clinical priority in preventive sports cardiology. While the overall cardiovascular risk of long distance running is low, the frequency of cardiac arrest and sudden death in middle-aged males during marathons has increased since the year 2000. An evidence-based strategy for reducing race-related acute cardiac events in this vulnerable subgroup is considered based on identification of the underlying cause....

 Open Access DOI:10.23937/2378-2951/1410050

Transient Isolated Right Ventricular Hypertrophy in A Neonate

Muhittin Celik, Heybet Tuzun, Bedri Aldudak and Osman Akdeniz

Article Type: Case Report | First Published: September 15, 2015

Transient isolated right ventricular hypertrophy is rarely encountered in neonates. We describe a term neonate in whom right ventricular hypertrophy was detected in the first postnatal day by echocardiography. There are several reasons that cause transient isolated right ventricular hypertrophy such as gestational diabetes, mother's dietary patterns, and certain drugs....

 Open Access DOI:10.23937/2378-3516/1410029

Respiratory Symptoms and Lung Function among Danish Construction Workers. A Cross-Sectional Study

Dorte Jessing Agerby Hanskov, Charlotte Brauer, Nina Breinegaard and Lilli Kirkeskov

Article Type: Original Research Article | First Published: October 2, 2015

This study investigated whether Danish construction workers had an increased prevalence of chronic obstructive pulmonary disease (COPD) or affected lung function and if the prevalence differed between types of jobs within construction....