Open Access DOI:10.23937/2469-5750/1510017

Fluorescence in Situ Hybridization (FISH) Copy Number Abnormalities at 6p (RREB1), 6q (MYB), and 11q (CCND1) Reliably Distinguish Metastatic Versus Benign Melanocytic Lesions

Zaid Hindi, Michael Sidiropoulos, Ayman Al Habeeb, Danny Ghazarian, Niloufar Hosseini and Kenneth J. Craddock

Article Type: Original Research | First Published: February 29, 2016

Multicolour FISH was performed using a commercially available probeset (Abbott Laboratories, Abbott Park, IL), on formalin-fixed, paraffin-embedded tissue samples from 40 tumours: 20 benign melanocytic nevi, and 20 metastatic melanomas within lymph nodes, as determined by histologic assessment. Fluorescent signals for each probe were enumerated by 2 observers in 30 cells each per lesion....

 Open Access DOI:10.23937/2469-5750/1510016

Geometric Botulinum Toxin Injections: A Simplified Reproducible Approach for Symmetric Face Rejuvenation

Hussein Ghanem and Heba Darwish

Article Type: Review Article | First Published: February 29, 2016

Different approaches have been described for botulinum toxin (BTX-A) injections for face rejuvenation. Most techniques are based on the experience of the injecting physician and his/her learning curve. We describe a simplified approach to achieve accurate reproducible symmetric results with physicians of variable experience levels....

 Open Access DOI:10.23937/2469-5750/1510015

A Rare Case of Erosive Pustular Dermatosis Involving the Upper Limb

Paul Ting-Yuan Cheng, Lissa Elaine Judd and Agneta Carol Fullarton

Article Type: Review Article | First Published: February 29, 2016

Erosive pustular dermatosis (EPD) is a cutaneous inflammatory condition, characterized by chronically non-healing lesions with sterile pustules and hyperkeratotic crusted erosions. Although rare, severe cases have been referred by dermatologists to plastic surgeons for management. The aim of this paper was to describe the presentation and management of extensive EPD as well as a review of current literature on this rare condition....

 Open Access DOI:10.23937/2572-3235.1510012

Establishing Radiopharmaceutical Standards at a Nuclear Medicine Unit in Malta

Leonie Pace Vincenti, Anthony Samuel and Francis Zarb

Article Type: Original Article | First Published: April 02, 2016

To establish radiopharmaceutical standards in a Nuclear Medicine Department in terms of radiochemical purity. Radionuclide standards were assessed in terms of radionuclide and chemical purity as well as pH as part of a quality control (QC) programme. An accurate and complete literature search was conducted identifying the needs, specific tests and resources required for the QC programme....

 Open Access DOI:10.23937/2572-3235.1510011

Aberrant Internal Carotid Artery in the Temporal Bone: A Case Report

Mehtap Cavusoglu, Semra Duran, Eda Elverici and Arzu Ozsoy

Article Type: Case Report | First Published: March 31, 2016

An aberrant internal carotid artery (ICA) in the middle ear is a rare and potentially serious vascular anomaly. Symptoms and signs of aberrant internal carotid artery are often non-specific, therefore radiographic investigation with the combination of CT scan and MRA is required for the diagnosis. It is also essential to inform physicians to avoid disastrous consequences....

 Open Access DOI:10.23937/2469-5866/1510010

Congenital Marin-Amat Syndrome and Asymmetric Crying Face: A Case Report

Arzu Ekici, Kursat Bora Carman, Ozlem Ozdemir, Aynur Kucukcongar and Mehmet Ali Ekici

Article Type: Case Report | First Published: March 18, 2016

Marin-Amat syndrome is a rare facial synkinesis and is characterized by the eyelid drooping on jaw opening. It is mostly an acquired phenomenon occurring after peripheral facial paralysis and very rarely congenital. Asymmetrical crying face is a rare minor congenital anomaly, that is the result of unilateral agenesis or hypoplasia of the depressor anguli oris muscle. Our case is the second one in which the onset of Marin-Amat Syndrome is congenital and the first case with asymmetric crying face....

 Open Access DOI:10.23937/2378-3656/1410093

A Case of Macrovascular Complications after Treatment with DPP-4 Inhibitor, Sitagliptin, in a Patient with Type 2 Diabetes Mellitus

Kyuzi Kamoi and Hideo Sasaki

Article Type: Case Report | First Published: February 29, 2016

Our case involved a 72-year-old woman [height, 1.47 m; body mass index (BMI), 19.9 kg/m2] with T2DM and cardiovascular disturbance. She had been diagnosed with non-obese T2DM (BMI, 20 kg/m2; anti-GAD antibody, negative) during examination for coldness of the lower extremities attributed to cerebral ischemic attack or transient ischemic attack (TIA) in June 2008 (at 65 years old)....

 Open Access DOI:10.23937/2378-3656/1410091

Multiple Myeloma and Amyloidosis Presenting as a Restrictive Lung Disease with Respiratory Failure

Marta Pereira, Luis Afonso, Goncalo Fernandes and Rui Araujo

Article Type: Case Report | First Published: February 20, 2016

Amyloidosis refers to the extracellular tissue deposition of fibrils resulting from abnormal folding of proteins. It may affect multiple organs, causing a broad range of symptoms, thus making the diagnosis particularly challenging. Polyneuropathy is one of the recognized manifestations of Amyloid Light-chain (AL) amyloidosis....

 Open Access DOI:10.23937/2377-9004/1410073

Vulvar Abcess due to Actinomyces Meyerii

Iacob Marcovici

Article Type: Case Report | First Published: January 30, 2016

A 14 years old girl presented with vulvar swelling, pain, and difficulty to walk. Her examination showed a tender and large left labial abscess (Figure 1). In OR, the patient underwent incision and drainage. Large amounts of puss were evacuated. Aerobic and anaerobic cultures were obtained. The patient's postoperative recovery was unremarkable and she was discharged on oral Ciprofloxacin 250 mg twice a day and Cephalexin 500 mg twice a day for 7 days....

 Open Access DOI:10.23937/2377-9004/1410072

Robotic Assisted Repair of Bilateral Fallopian Tube Prolapse after Vaginal Hysterectomy

Ruben J. Barrera -Vera, Kimberley Chiu, Perry Cohen, Victoria Chernyak and Nicole S. Nevadunsky

Article Type: Case Report | First Published: January 30, 2016

Hysterectomy is the most frequent major surgical procedure performed in gynecology. Fallopian tube prolapse into the vaginal vault is a rare but known reported complication of hysterectomy, estimated to occur in approximately 0.1% of procedures, although the true incidence of this complication is difficult to estimate, as many cases are either unreported or unrecognized. It is three times more frequent after vaginal hysterectomy....