Open Access DOI:10.23937/2469-5769/1510016
Dental Neglect Affecting Oral Health Status in India
Aditi Mathur, Anmol Mathur and Vikram Pal Aggarwal
Article Type: Original Article | First Published: March 26, 2016
The dental treatment is still a night mare for most of the people. Dental neglect have tight bond with dental caries. Dental caries has been called as scourge of modern civilization and is without doubt, one of the mankind's most prevalent chronic diseases. The concept of dental neglect may offer a viable linkage between dental health and the cultural, social and attitudinal factors. Australia's 1993 children's protection act defines neglect as "any serious omission or commission by a person whi...
Open Access DOI:10.23937/2469-5734/1510026
Unusual Necrosis of the Lower Lip Following a Varicella Zoster Recurrence
Adam P McCormick, Robert J Kanas, Mark Orton and Ted Rice
Article Type: Case Report | First Published: March 24, 2016
Recurrence of varicella-zoster virus (VZV) or herpes zoster (HZ) is a relatively common cutaneous eruption among the elderly (> 60 yrs.) or immunocompromised patients. It usually presents as an exanthematous pruritic rash that becomes vesicular, pustular or ulcerative. HZ commonly involves a unilateral thoracic dermatome. When the trigeminal nerve is involved, a unilateral eruption in the oral cavity and ipsilateral side of the face may occur following a division of the trigeminal nerve. In rare...
Open Access DOI:10.23937/2378-3419/3/2/1051
Improved Antitumoral Efficacy of Mesothelin Targeted Immune Activating Fusion Protein in Murine Model of Ovarian Cancer
Yang Zeng, Binghao Li, Patrick Reeves, Chongzhao Ran, Zhao Liu, Mojgan Agha-Abbaslou, Jianping Yuan, Pierre Leblanc, Ann Sluder, Jeffrey Gelfand, Timothy Brauns, Mark Poznansky and Huabiao Chen
Article Type: Research Article | First Published: March 30, 2016
The candidate therapeutic fusion protein (scFv-MtbHsp70) is a recombinant Mycobacteria tuberculosis heat shock protein 70 (MtbHsp70) fused with a single chain antibody (scFv) targeting mesothelin, combining the immune-targeting capacity of the scFv with the broader immune activating capabilities of MtbHsp70. The previous version of the fusion protein, VIC-007, markedly enhanced survival of ovarian tumor-bearing mice through the augmentation of tumor-specific cell-mediated immune responses....
Open Access DOI:10.23937/2378-3419/3/2/1050
The Many Faces of Lung Cancer
Luciano Cardinale, Valeria Angelino, Edoardo Piacibello and Andrea Veltri
Article Type: Short Review | First Published: March 27, 2016
The aim of this short review is to illustrate various CT findings of lung cancer (LC) other than the classical aspects. Overall, LC is the second commonest cancer in men and women in the developed world and small cell lung cancer (SCLC) accounts for about 20-25% of cases. In comparison with Non-Small Cell Lung Cancer (NSCLC), SCLC typically exhibits more aggressive behaviour with rapid growth, early metastatic spread and frequent association with paraneoplastic syndromes....
Open Access DOI:10.23937/2378-3419/3/2/1049
Cardiac Involvement in Carcinoid Syndrome: Role of Serial Standard and Contrast Echocardiography
Francesca Casadei, Antonella Moreo, Francesco Musca, Paola Vallerio, Miriam Stucchi and Cristina Gannattasio
Article Type: Case Report | First Published: March 23, 2016
We report a case of a 52 year-old woman with cardiac carcinoid metastases who developed a moderate tricuspid regurgitation without the typical findings of carcinoid valve disease. Echocardiography allowed to define the mechanism of valve insufficiency. Moreover, standard and contrast echocardiography permitted characterization of the structural features of the mass, size measurement and monitoring growth during follow-up....
Open Access DOI:10.23937/2572-3308.1510013
What is known about Oral Tolerance
Smolkin YS and Grishchenko EA
Article Type: Short Review | First Published: March 29, 2016
Healthy people are constantly exposed to foreign proteins but in contrast to allergic individuals they do not develop any immune response. Cornerstone of such difference is tolerance. Oral tolerance in allergic people is of highest priority. Oral tolerance is specific suppression of cellular and/or humoral immune responses to an antigen by prior administration of the antigen by the oral route. It may develop naturally or be allergen immunotherapy (AIT) induced....
Open Access DOI:10.23937/2572-3308.1510012
Valsartan/Hydrochlorothiazide Induced Pemphigus Foliaceus
Rosa Gimenez-Garcia and MariaNunez-Cabezon
Article Type: Case Report | First Published: March 29, 2016
The term pemphigus refers to a group of autoimmune intraepidermal blistering diseases of skin and mucous membranes in which there is loss of adhesion between keratinocytes, following disruption of desmosomes, as a consequence of autoantibody binding to various antigens on the cell surface. Drug-induced pemphigus mimics idiopathic pemphigus clinically, histopathologically and immunologically. Exogenous factors as burns, UV radiation and X-rays can be involved in the development of pemphigus....