Open Access DOI:10.23937/2469-5750/1510019
Targeted Prodrug Design for the Treatment of Malignant Melanoma
Marcella Gabrielle Mendes Machado, Paulo Renato Yamasaki, Jean Leandro dos Santos and Chung Man Chin
Article Type: Short Review | First Published: April 04, 2016
Malignant melanoma is a serious health problem once the current chemotherapy exhibits resistance to traditional drugs. Several challenges must be overcome during drug design in order to increase the efficacy and safety of the new drugs. Therefore, the specific chemical release of cytotoxic agents near to the target is an attractive approach to improve the anticancer activity and reduce the systemic toxicity. Herein, this review article describes the advances in the development of targeted prodru...
Open Access DOI:10.23937/2378-3397/1410040
Comparative Study of Laparoscopic Versus Open Resection of Colorectal Liver Metastasis
Christian Hunnicke Petersen, Peter Norgaard Larsen, Jan Storkholm, Nicolai Aagaard Schultz and Kenneth Hojsgaard Jensen
Article Type: Original Article | First Published: March 30, 2016
Laparoscopic liver resection is gaining increased application in the treatment of colorectal liver metastases (CRLM). The aim of this study is to compare safety and feasibility of minor laparoscopic liver resection vs. open liver resection in patients with CRLM. One hundred and twenty-eight patients who underwent minor resection of CRLM were retrospectively reviewed. Sixty-four consecutive cases of laparoscopic liver resections (LLR) were compared to a matched control group of 64 open liver rese...
Open Access DOI:10.23937/2378-3516/1410043
Platelet to Lymphocyte Ratio as a Novel Prognostic Marker in Male Patients with Chronic Obstructive Pulmonary Disease
Sezgi Sahin Duyar, Yalcin Solak, Dilek Tekis, Jale Karakaya, Ferit Kuscu and Asuman Erarslan
Article Type: Original Article | First Published: March 31, 2016
Neutrophil to lymphocyte ratio(NLR) and platalet to lymphocyte ratio (PLR) are recently defined novel inflammatory markers which are readily available. Their prognostic signifigance has been shown for a number of inflammatory diseases. A recent study evaluated the role of NLR in patients with chronic obstructive pulmonary disease(COPD). Thus, we aimed to investigate the relations between NLR, PLR and severity of COPD in male patients who had stable disease....
Open Access DOI:10.23937/2469-5807/1510030
Reduced and Thinned Elastic Fibers in Skin Tag
Ahmed Abdullah Alhumidi
Article Type: Mini Review | First Published: March 29, 2016
This is a retrospective study in which thirty histopathological specimens of fibroepithelial polyp (skin tag) were examined. Their paraffin blocks were collected from the archives of the Pathology Department, king khalid University hospital, Riyadh, Saudi Arabia, during the period from 2010 to 2012. Age of the patient, sex, and site, of the lesions as well as type of skin tag were recorded. Sections from each paraffin block were cut by a microtome at 5-micron thickness, stained with hematoxylin ...
Open Access DOI:10.23937/2572-4215.1510006
The Disconnect between Treatment Outcome Data and Reimbursement for the Treatment of Anorexia Nervosa
David M. Garner, Meggan Desmond, Julie Desai and Jan Lockert
Article Type: Research Article | First Published: April 06, 2016
A major problem plaguing the discussion of insurance reimbursement for the treatment of anorexia nervosa is the apparent gap between research on variables associated with outcome and the formulas used for reimbursement. Outside of the mental health world, insurance coverage is driven by advanced analytics and actuarial data. However, in calculating insurance reimbursement for the treatment of anorexia nervosa, actuarial data associated with short-term and long-term outcomes are not utilized. Ins...
Open Access DOI:10.23937/2378-3419/3/2/1052
Relation between Thyroid Disease and Breast Cancer
Ersin Turan and Baris Sevinc
Article Type: Original Article | First Published: March 31, 2016
Benign thyroid nodules are most common surgically treated endocrine disorder. Breast cancer is the most common cancer type among women. In the recent study, we aimed to detect the relation between breast cancer and benign thyroid nodules. The patients operated because of breast cancer and have a definite diagnosis with pathological evaluation were included in this prospective study....
Open Access DOI:10.23937/2378-346X/1410049
Routes of Oxidative Stress in Age-Related Macular Degeneration
Manresa N, Mulero J, Losada M and Zafrilla P
Article Type: Review Article | First Published: May 07, 2016
The pathogenic mechanism of AMD is poorly understood. The ROS and nitrogen species produced during stress may damage crucial biomolecules of the retinal pigment epithelium (RPE) cells. There is a strong relation between stress oxidative and inflammatory response in the pathology of the AMD. Actually, there are many routes of oxidative stress related with AMD but the most representative are: autophagy/heterophagy, apoptosis, and iron, DNA and antioxidant enzymes. Autophagy is a cellular housekeep...
Open Access DOI:10.23937/2378-3001/3/2/1044
Trigeminal Neuropathy as a Relapse in Behcet Disease
Goncalo Cacao, Isabel Moreira, Jose Eduardo Alves, Fatima Farinha and Ernestina Santos
Article Type: Case Report | First Published: March 29, 2016
A 49 years old woman, diagnosed with Neuro-Behcet, was admitted with complains of numbness, aching and periods of electric shock-like pain in right side of the face. Associated with painful oral ulcers, anorexia, nausea and gait instability. Neurological examination revealed dysesthesia on right trigeminal nerve territory, horizontal-rotatory nistagmus on horizontal gaze bilateral with fast phase to the right and tandem instability. Brain MRI revealed new lesions. It was assumed a rhombencephali...
Open Access DOI:10.23937/2378-3001/3/2/1043
Neuromyelitis Optica Spectrum Disorder in A Ninety-year-old Woman. A Case Report
Romero-Delgado Fernando, Cuello Juan-Pablo, Garcia-Dominguez Jose-Manuel, Higueras-Hernandez Yolanda, Goicochea-Briceno Haydee, Guzman-de-Villoria Juan Adan and Martinez-Gines Maria-Luisa
Article Type: Case Report | First Published: March 28, 2016
Neuromyelitis Optica (NMO) is an inflammatory demyelinating, necrotizing disease of the central nervous system, with a predilection for the optic nerves and spinal cord. Clinical, radiological and immunopathological characteristics distinguish it from multiple sclerosis (MS). Recently, new diagnostic criteria have been published, and the terms NMO and neuromyelitis optica spectrum disorder (NMOSD) have been unified, allowing a diagnosis of NMOSD on clinical grounds or on anti-AQP4 antibody statu...
Open Access DOI:10.23937/2572-3308.1510015
State of the Art on Food Allergy Immunotherapy
Paola L Smaldini and Guillermo H Docena
Article Type: Mini Review | First Published: March 31, 2016
Food allergy is increasing in prevalence in westernized countries, leading to significant morbidity including nutritional deficiencies and the potential for fatal anaphylaxis during accidental exposure to the allergen. The current treatment remains strict avoidance, although the disease is not cured. Allergen specific immunotherapy for food allergy is currently being actively evaluated, but is still experimental. Nevertheless, it is the only disease-modifying therapy for IgE-mediated food allerg...