Open Access DOI:10.23937/2474-3631/1510018
Alcoholism and Alcoholic Psychoses Trends in Late-Soviet and Post-Soviet Russia
Y E Razvodovsky
Article Type: Letter to the Editor | First Published: April 19, 2016
The aim of the present paper was to discuss the trends in the incidence of alcoholism and alcoholic psychoses in late-Soviet and post-Soviet Russia in relation to social changes, quality of health care and the laws regulating production and sales of alcohol. Here we specified the number of alcohol dependent patients without alcoholic psychoses and the number of alcohol dependent patients with alcoholic psychoses, witches was admitted to hospital for the first time as incidence of alcoholism and ...
Open Access DOI:10.23937/2378-3656/1410100
Rx for Disaster: When Medication Non-adherence becomes an Emergency
Lindsay S. Leech, Nicole G. Tasker and Julie L. Welch
Article Type: Case Report | First Published: April 13, 2016
This case report describes a 35-year-old woman who presented to the Emergency Department (ED) after a seizure. Her evaluation revealed a rare cause of her seizures, confounded by medication non-adherence. She was emergently treated and admitted for further management. With standard patient education, social services, and outpatient follow-up, she did well for three years, however had two subsequent admissions for recurrent seizures from non-adherence. This case demonstrates a rare but treated ca...
Open Access DOI:10.23937/2572-3235.1510014
Rectifying Radon's Record: An Open Challenge to the EPA
Jeffry A Siegel, Charles W Pennington, Bill Sacks and James S Welsh
Article Type: Review Article | First Published: May 28, 2016
The American Lung Association has recently led a national workgroup to develop The National Radon Action Plan: A Strategy for Saving Lives. The U.S. Environmental Protection Agency (EPA) is the lead governmental organization projected to implement this plan. The stated intent of the plan is to address the 'radon problem' in the United States, with the aim of saving 3,200 lives by the year 2020 through preventing at least a portion of the lung cancer mortality that is assumed to arise from inhali...
Open Access DOI:10.23937/2378-3656/1410099
Pulmonary Lymphangitic Carcinomatosis due to Metastatic Adenocarcinoma of the Lung: A Case Report
Somaya AM Albhaisi and Neama Luqman
Article Type: Case Report | First Published: March 31, 2016
Pulmonary lymphangitic carcinomatosis (PLC) is part of the spectrum of metastatic disease. Most cases result from dissemination of adenocarcinomas. Micro hematogenous spread to the periphery of the lung, with subsequent retrograde, centripetal lymphatic extension toward the hilar region, is the responsible mechanism in approximately 75% of patients. The remaining cases are due to retrograde extension from a hilar tumor or from an ipsilateral lung or breast carcinoma. In the latter settings, the ...
Open Access DOI:10.23937/2378-3001/3/2/1046
Multiple System Atrophy: Moving towards a Multi-mechanistic Hypothesis
Monica Federoff
Article Type: Commentary | First Published: April 09, 2016
With an estimated incidence of 3-4 per every 100,000 individuals among adults 50-99 years of age, Multiple System Atrophy (MSA) is a rare progressive neurodegenerative disease clinically characterized by the following trio: cerebellar ataxia, parkinsonism and autonomic dysfunction in conjunction with pyramidal signs. MSA usually progresses over a 7-9 year period, with an average age of onset of 57 and affects both sexes equally....
Open Access DOI:10.23937/2378-3001/3/2/1045
Anterior Junction Syndrome Caused by Neuromyelitis Optica
Ma Eugenia Garcia Garcia, Javier Casas Limon, Aida Orviz Garcia and Alberto Marcos Dolado
Article Type: Case Report | First Published: April 08, 2016
The anterior junction syndrome is a specific manifestation caused by optic nerve involvement at the junction with the optic chiasm and the contralateral inferonasal nerve fibers (Wilbrand's Knee). Lesions at this point show a specific pattern of visual impairment which is characterized by an advanced monocular visual field loss, together with circumscribed visual field defects, respecting the vertical midline in the other eye (junctional scotoma). Although pituitary adenomas are the most frequen...
Open Access DOI:10.23937/2469-5793/1510030
Family Resource and Health Perspective of Children with Turner Syndrome: A Model Testing
Jih Yuan Chen, Mei Chyn Chao, Sheng Yi Yang, Yea Hui Xiao and Ying Hui Lin
Article Type: Quantitative Research Article | First Published: April 08, 2016
The objectives of this study were to elucidate family interaction and psychophysical health among families with members who have Turner Syndrome (TS) through structural equation modeling (SEM), and to investigate differences among patients and their fathers and mothers related to family support, functioning, and hardiness, and mental and physical health. Subjects were recruited from a genetic disease section of a pediatric clinic in a southern Taiwan medical center. There were 59 subjects aged 2...
Open Access DOI:10.23937/2469-570X/1410029
Mesenchymal Stem Cell: Considerations for Manufacturing and Clinical Trials on Cell Therapy Product
Yen-Shun Chen, Yi-An Chen, Pei-Hsun Tsai, Chih-Ping Chen, Sheng-Wen Shaw and Yogi Hsuan
Article Type: Short Review | First Published: March 31, 2016
Mesenchymal stem cell (MSC) have the ability to self-renew and differentiate into various cell type, and they are the most widely used cell type in stem cell therapies. Designing a new MSC drug is an intricate process, considering the versatile nature of cells and the susceptibility to manufacturing processes. As the number of MSC-based clinical trials rapidly grows over the years, there is an urgent need to develop a more stringent method to characterize MSC for quality and to enhance scrutiny ...