Open Access DOI:10.23937/2469-5807/1510031
BerEP4 and AE1/3 are Reliable Markers of Epithelial Content for Biomarker Discovery Using Reverse Phase Protein Arrays (RPPA)
Ola H Negm, James C Hassall, Wakkas Fadhil, Alain Pitiot, Patrick J Tighe, Cedric Marchessoux and Mohammad Ilyas
Article Type: Mini Review | First Published: April 01, 2016
Biomarker studies are notorious for their high failure rate. Despite huge investment by both academia and industry, very few biomarkers make the transition from interesting laboratory data to tests with clinical utility. The reasons for this are manifold. Some biomarkers are "true" biomarkers inasmuch as they are robust and reproducible but the information they provide does not help to improve patient management beyond that informed by traditional clinical parameters....
Open Access DOI:10.23937/2469-5734/1510027
Oral Hygiene Practices among Fixed Orthodontic Patients in a University Dental Setting
Lee Jin Han, Asma Alhusna Abang Abdullah and Nurul Asyikin Yahya
Article Type: Research Article | First Published: April 12, 2016
A self-administered questionnaire was answered by 261 fixed orthodontic patients. The questionnaire addressed two aspects: socio-demographic characteristics and oral hygiene practices. Socio-demographic variables included age, gender, race, level of education, and smoking status. Oral hygiene practices were assessed through questions on the type and frequency use of toothbrush, other cleaning measures used daily and professional mechanical tooth cleaning (PMTC) during the orthodontic treatment p...
Open Access DOI:10.23937/2378-346X/1410050
Intraoperative Corneal Incision Evaluation with Trypan Blue Technique
Ozcan Kayikcioglu, Sinan Bilgin and Mahmut Oguz Ulusoy
Article Type: Research Article | First Published: May 13, 2016
In this report, we aimed to determine wound leakage by instillation of trypan blue onto main incision and side port incisions during phacoemulsification surgery with clear corneal incision technique. Thirty-four eyes with cataract of 34 patients, who were operated by phacoemulsification method were included in the study. Incision points were hydrated by balanced saline solution and leakage was controlled at the end of the surgery. Trypan test revealed minor leakage in 23 out of 34 eyes (67.6%). ...
Open Access DOI:10.23937/2377-3634/1410057
Continuous Insulin Releasing and Blood Sugar Monitoring via Dental Implant Supported Semi-Implanted Device
Yu-Jung Li
Article Type: Research Article | First Published: May 17, 2016
As life expectancy prolonged currently, geriatrics become important and therefore it is urgent to improve the life quality throughout the chronic and critical diseases among the elderly above sixty-fifth years old. On the other hand, diabetes mellitus (DM) is the most famous chronic and metabolic disease which may lead to many cardiac, renal and infectious complications. Therefore regular blood sugar control is extremely important in diabetic management to avoid further complications. However, t...
Open Access DOI:10.23937/2377-3634/1410056
The Effects of a One-week Short Intensive Insulin Intervention on Insulin Sensitivity in Patients with Poorly Controlled Type 2 Diabetes
Jean-Claude Katte, Eugene Sobngwi, Vicky Kamwa, Mesmin Y Dehayem, Jean-Louis Nguewa, Andre-Pascal Kengne and Jean Claude Mbanya
Article Type: Research Article | First Published: May 12, 2016
A 3-4 week of intensive insulin intervention corrects hyperglycemia, improves insulin secretion, glycemic control, and insulin sensitivity in people with type 2 diabetes mellitus. We assessed the effect of a shorter course of intensive insulin therapy on insulin sensitivity in people with T2DM. Fifteen poorly controlled subjects with severe hyperglycemia were hospitalized and treated with intensive insulin therapy for 7 days. The short insulin tolerance test was performed before and after the in...
Open Access DOI:10.23937/2378-3419/3/2/1054
New Insights into Functional Implication of Genetic Variation in Association with Cancer
Yanfeng Zhang
Article Type: Review Article | First Published: April 16, 2016
Investigations of the genetic basis of cancers have identified hundreds of robust risk loci associated with cancers using large-scale, case-control, candidate gene studies as well as genome-wide association studies (GWASs) during the past ten years. Most leading single nucleotide polymorphisms (SNPs) associated with cancer sensitivity lie in non-protein-coding regions, suggesting the potentially regulatory functions as targets for susceptible variants. That is a critical question to understand t...
Open Access DOI:10.23937/2378-3419/3/2/1053
Prdx Overexpression in Tumor Tissue of Breast Cancer Patients
Jillian Muhlbauer and Shelley A Phelan
Article Type: Original Research | First Published: April 08, 2016
Peroxiredoxin (Prdx) proteins are evolutionarily conserved thiol-specific antioxidant enzymes that reduce various cellular peroxides, protecting cells from oxidative damage. Prdxs also have been demonstrated to play an important role in regulating redox-sensitive cell signaling in a number of cell processes. Prdxs have been implicated in cancer biology, and are upregulated in many cancers including breast cancer, as well as several breast cancer cell lines. To explore the entire Prdx family in b...
Open Access DOI:10.23937/2377-4630/3/2/1045
Feasibility and Timing of Craniosynostosis Surgery in a Child with Hypoplastic Left Heart Syndrome
C Hochhold, P Paal, G Luckner, M Rasse and C Velik-Salchner
Article Type: Case Report | First Published: April 11, 2016
Nowadays, children with hypoplastic left heart syndrome (HLHS) survive longer. Thus, the management of such patients undergoing non-cardiac surgery is of increasing relevance. A 12-month-old boy with HLHS following stage II Norwood palliation and Apert syndrome required extended craniosynostosis surgery because of elevated intracerebral pressure. Since extensive blood loss as well as hemodynamic instability were expected, anesthetic and surgical management were carefully planned in a multidiscip...
Open Access DOI:10.23937/2469-5742/1510015
Mesothelioma of the Tunica Vaginalis Testis: Case Report and Review
Ruiz Hernandez M, Fabuel Alcaniz JJ, Gutierrez-Pecharroman AM, Romio de las Heras E, Rodriguez-Patron Rodriguez R, Varona Crespo C and Burgos Revilla FJ
Article Type: Case Report | First Published: May 20, 2016
A 93-year-old man with chronic hydrocele and no history of asbestos exposure underwent a hydrocelectomy, which revealed several nodules in the tunica vaginalis. The histopathological diagnosis was malignant mesothelioma, requiring a second procedure. A radical inguinal orchiectomy with hemiscrotectomy was performed, reporting tumor-free surgical margins; therefore, no adjuvant treatments were given. Three months postoperative, the patient continued asymptomatic, scrotal examination was normal, a...