Open Access DOI:10.23937/2378-3419/3/4/1063

Estimating Relapse Free Survival as a Net Probability: Regression Models and Graphical Representation. An Application of a Large Breast Cancer Case Series

Annalisa Orenti, Elia Biganzoli and Patrizia Boracchi

Article Type: Original Article | First Published: August 12, 2016

In most clinical studies, the evaluation of the effect of a therapy and the impact of prognostic factors is based on relapse-free survival. Relapse free is a net survival, since it is interpreted as the relapse-free probability that would be observed if all patients experienced relapse sooner or later. Death without evidence of relapse prevents the subsequent observation of relapse, acting in a semi-competing risks framework. Relapse free survival is often estimated by standard regression models...

 Open Access DOI:10.23937/2378-3419/3/4/1062

Cancer Risk among Physicians is Different from that among Non-Physicians: An Observational Pilot Study

Hyun Young Kim

Article Type: Pilot Study | First Published: July 29, 2016

We conducted a retrospective, case-control study on cancer risk among physicians and non-physicians at a health screening center. A total of 1,110 Korean subjects aged 30 to 65 years were assessed for cancer risk. A physician group (primary clinic, N = 147, tertiary hospital, N = 123) and non-physician group (N = 840) were included....

 Open Access DOI:10.23937/2474-3674/1510019

Pre-Hospital Ultrasound: Current Indications and Future Perspectives

Mirko Zanatta, Piero Benato and Vito Cianci

Article Type: Review Article | First Published: July 20, 2016

The mission of pre-hospital medical service is to provide rapid and high quality life support. The development of specific protocols, the availability of new diagnostic tools have determined a significant improvement of pre-hospital care. The use of ultrasound in the pre-hospital medical service is a new and reliable diagnostic device....

 Open Access DOI:10.23937/2474-1353/1510030

Breast MRI Screening for the Clinician: Evolution to Current Evidence-Based Practice

R Jared Weinfurtner and Jennifer Drukteinis

Article Type: Review Article | First Published: August 15, 2016

The utility of MRI in the detection of breast cancer has evolved over the last few decades. It is now the most sensitive imaging tool available for the diagnosis of invasive breast cancer. There are drawbacks however, namely increased cost in comparison to screening mammography and decreased specificity. Thus, it is important to tailor the use of breast MRI to specific screening populations in order to maximize the benefit to drawback ratio. In this review, the current evidence for screening MRI...

 Open Access DOI:10.23937/2474-1353/1510029

Desquamative Inflammatory Vaginitis and Other Persisten Vaginitis: A Case Report

Miguel Angel Acosta-Benito

Article Type: Case Report | First Published: August 10, 2016

A 75% of women will have at last one episode of vaginitis, which can become persistent in more than a half of them. Its symptoms are disturbing and carry a psychological charge for patients. Although it is frequently caused by bacterial vaginosis, vaginal candidiasis or trichomoniasis, there is other aetiology that must be taken into account, as noninfectious vaginitis and atrophic vaginitis. Desquamative inflammatory vaginitis is a disease of unknown origin that appears associated to intense va...

 Open Access DOI:10.23937/2469-5793/1510039

Prevalence of Burden, Family Dysfunction and Depression in Primary Caregiver of Pediatric Patients with Disabilities

Pineda-Frutos Maria Fernanda, Jimenez-Baez Maria Valeria, Marquez-Gonzalez Horacio, Jimenez-Marquez Abigail, Jaime-Gonzalez Hector, Sandoval-Jurado Luis and Medina-Andrade Luis Angel

Article Type: Original Article | First Published: July 18, 2016

Primary caregivers (PC) health and psychological well-being, in cases of children with disabilities must be studied for the high impact on life quality of both, caregivers and children. Our objective was to analyze the epidemiological profile of children with disabilities and their primary caregiver (PC), determine the presence and severity of depression in the PC, measures the burden degree of the PC and estimate the presence of family dysfunction....

 Open Access DOI:10.23937/2469-5793/1510038

Family Accommodation in the Different Dimensions of the Symptoms of Obsessive-Compulsive Disorder

Mariana Bonati de Matos, Andressa Jacondino Pires, Jessica Puchalski Trettim, Carolina Coelho Scholl, Viviane Porto Tabeleao, Rafaelle Stark Stigger, Mariane Lopez Molina, Ricardo Tavares Pinheiro and Luciana de Avila Quevedo

Article Type: Original Article | First Published: July 18, 2016

This was a cross-sectional study with patients and their family members diagnosed with OCD at a research clinic. The instruments used in this study were: the Mini International Neuropsychiatric Interview (MINI PLUS), the Yale-Brown Obsessive Compulsive Scale (Y-BOCS), the Dimensional Yale-Brown Obsessive-Compulsive Scale (DY-BOCS) and the Family Accommodation Scale for Obsessive-Compulsive Disorder - Interviewer-Rated (FAS-IR)....

 Open Access DOI:10.23937/2378-3672/1410022

Dextran-Conjugated Anti-Immunoglobulin Antibodies: A Powerful Tool for Studying B Cell Receptor-Mediated Signaling

Clifford M Snapper

Article Type: Mini Review | First Published: August 03, 2016

Anti-Ig-dex was originally conceived as a means for modeling BCR-mediated B cell activation in response to polysaccharides. Polysaccharides consist of long chains of repeating sugars that are capable of multivalent cross-linking of BCR on the surface of polysaccharide-specific B cells. Normal B cells of a given antigen-specificity are present in the host at frequencies so low that studying the behavior of such B cells is highly challenging technically....

 Open Access DOI:10.23937/2378-3672/1410021

Inhibition of Macrophage Activation and Lymphocyte Function of Annona vepretorum Mart. (Annonaceae) Natural Products

Tatiana Barbosa dos Santos, Cassio Santana Meira, Cibele do Carmo Miranda, Leociley Rocha Alencar Menezes, Livia Macedo Dutra, Liviane do Nascimento Soares, Andersson Barison, Emmanoel Vilaca Costa, Elisalva Teixeira Guimaraes and Milena Botelho Pereira Soares

Article Type: Original Article | First Published: July 27, 2016

Immunomodulatory drugs are widely used for the treatment of inflammatory and immune-mediated conditions; however, their prolonged use is usually associated with the appearance of side effects and many immune disorders continuous without a suitable treatment. Natural products are an important source of therapies to a variety of illnesses. The present work investigated the immunomodulatory activity of a hexane extract and isolated compounds from Annona vepretorum Mart....

 Open Access DOI:10.23937/2474-3658/1510017

Lemierre's Syndrome without Internal Jugular Vein Thrombophlebitis: A Diagnostic Conundrum

Gbolahan O Ogunbayo, Josephine Adunse, Odunayo Olorunfemi and Nashwa Abdulsalam

Article Type: Case Report | First Published: August 16, 2016

A previously healthy 23-year-old male presented with fever and shortness of breath. His illness initially started six days before presentation with a sore throat. Two days later he developed fevers with associated chills, rigors, and night sweats. He also complained of myalgias, non-productive cough, a right-sided chest pain, and shortness of breath on exertion, as well as nausea, vomiting, abdominal pain, and diarrhea. His symptoms continued to worsen until he became dyspneic at rest and was br...