Open Access DOI:10.23937/2572-407X.1510035
Refractory Hyperglycemia and Hypokalemic Paralysis: Rare Initial Presentation of Cushing Disease
Richmond R Gomes and Habiba Akhter
Article Type: Case Report | First Published: 2023/12/30
Cushing syndrome (CS) is a rare disease that results from prolonged supraphysiologic tissue action of glucocorticoids. This can be caused by a tumor of the adrenal glands, the lungs or the pituitary gland. When a pituitary tumor produces too much ACTH (adrenocorticotropic hormone), it causes the overproduction of cortisol by the adrenal glands. When the pituitary is the source of the over production, it is called Cushing's disease. Cushing's disease (CD) remains a diagnostic and therapeutic chal...
Open Access DOI:10.23937/2572-4010.1510048
The Impact of Male Obesity on Sex Hormones
Nicolle de Godoy Moreira e Costa, Joana Ferro Machado de Almeida, Amanda Delfino Braccini, Otávio Augusto Matos Gonçalves and Maria Angela Zaccarelli-Marino
Article Type: Original Article | First Published: 2023/12/30
Retrospective study; reviewed the medical records: 42 male patients; ABC region, São Paulo state; aged between 28 and 69 years. Evaluated: body weight, height, WC, total cholesterol (TC) and fractions, liver enzymes, alkaline phosphatase (AP), total testosterone (TT), free testosterone (FT), sex hormone-binding globulin (SHBG), estradiol (E2), luteinizing hormone (LH), follicle-stimulating hormone (FSH), Body Mass Index (BMI); men previously diagnosed with obesity (BMI ≥ 30 kg/m2). A descript...
Open Access DOI:10.23937/2378-3001/1410125
Validation of a Suitable Housekeeping Gene in Human Neuroblastoma SHSY-5Y Cell-Line Treated with Steroid Hormones Progesterone and Testosterone
Paula Maria Neufeld, Jonas Frai, Veronika Matschke, Carsten Theiss and Sarah Stahlke
Article Type: Original Article | First Published: 2023/12/30
In this study, we evaluated the stability of three common housekeeping genes, GAPDH, beta-Actin, and 18S-rRNA, in human neuroblastoma SHSY-5Y cells exposed to varying levels of steroid hormones like progesterone (P4) and testosterone. Housekeeping genes serve as reliable internal controls, assumed to maintain consistent expression across diverse tissues and experimental conditions. Since steroid hormones act as ligand-activated transcription factors, directly impacting gene transcription, the id...
Open Access DOI:10.23937/2378-3397/1410159
Duodenal Lipoma Causing Recurrent Duodenal Obstruction: A Rare Case, Managed Surgically
Sachin Jain, Neeraj Goel and Amit Kumar
Article Type: Case Report | First Published: 2023/12/24
Duodenal lipomas are rare gastrointestional (GI) tumours. Due to their rarity and the uncertainty of their presentation, as the majority of these lesions are asymptomatic, these lesions are occasionally overlooked. Most patients experience symptoms in lesions > 2 cm in diameter. These lesions can present with GI haemorrhage, bowel obstruction and abdominal pain or discomfort. Symptomatic duodenal lipoma requires excision. ...
Open Access DOI:10.23937/2469-5769/1510121
Vertical Transmission of Scrub Typhus in Newborn: A Case Report
Foram A Patel, Bharat Muliya and Dhruti Pandya
Article Type: Case Report | First Published: 2023/12/26
Scrub typhus is an acute febrile mite-born rickettsial infection caused by Orientia tsutsugamushi (formerly called Rickettsia tsutsugamushi ). This infection is very uncommon in neonates. We report a case of 8-day-old newborn presenting with clinical features mimicking severe sepsis but were subsequently diagnosed with primary scrub typhus infection. The timely treatment resulted in dramatic response and complete recovery....
Open Access DOI:10.23937/2469-5750/1510122
Dermoscopy of Cheilitis: A Comprehensive Review of Principal Findings
Imane KACIMI ALAOUI, Sara ELLOUDI, Sara EL-AMMARI, Zakia DOUHI, Meryem SOUGHI, Hanane BAYBAY and Fatima-Zahra MERNISSI
Article Type: Comprehensive Review | First Published: 2023/12/23
Cheilitis, an inflammatory condition affecting the lips, presents with various etiologies and clinical manifestations. Early and accurate diagnosis of cheilitis is essential for appropriate treatment and management. Dermoscopy has emerged as a valuable diagnostic tool in dermatology, allowing for non-invasive visualization of skin structures. This review article aims to provide an in-depth understanding of dermoscopic findings in the context of cheilitis...
Open Access DOI:10.23937/2378-2951/1410288
A Young African Man with Familial Hypercholesterolemia Presenting with Coronary Artery Disease
Justine Namukasa, Daniel Iraguha, Happy Lilian Mbabazi, Isaac Ssinabulya and Charles Lugero
Article Type: Case Report | First Published: 2023/12/24
40-year-old African man presented with typical anginal pain and cutaneous swelling. Examination revealed had corneal arcus, multiple tendon xanthomas and xanthelasmas. The investigation panel showed dyslipidemia with very high total cholesterol of 642.3 mg/dl, very high low-density lipoprotein of 531 mg/dl, low high-density lipoprotein of 36.7 mg/dl and high triglyceride of 248.1 mg/dl and he had a positive stress test....
Open Access DOI:10.23937/2572-4037.1510071
Correlation of Mothers' Educational Level and Depression of Mothers with PKU Children
Iakovou K and Schulpis K
Article Type: Editorial | First Published: 2023/12/24
Phenylketonuria (PKU) is an inborn error of phenylalanine (phe) metabolism due to the deficiency of the hepatic enzyme phe hydroxylase activity. Mothers of phenylketonuric children are obligatory heterozygous of the disease. PKU is characterized by high phe blood levels resulting in executive function impairment, convulsions and microcephaly caused by toxic effect of phe accumulation in the brain...
Open Access DOI:10.23937/2474-3682/1510228
Cutaneous Lymphangioma Circumscriptum: Seeing Closer
Marcela de Oliveira Pires, Leonor Aires Figueiredo and Cristina Amaro
Article Type: Clinical Image | First Published: 2023/12/24
A previously healthy seven-year-old female presented to the Pediatric Dermatology clinic with multiple, grouped, red fluid-filled lesions on the left side of the torso, that appeared about one month earlier. No other symptoms, such as pain, pruritus or fever were present....