Open Access DOI:10.23937/2469-5807/1510069
C3orf21 and Notch Signaling in Cancer：A Potential Biomarker
Yongjun Zhang, Dehou Deng and Wenlong Bao
Article Type: Perspective Article | First Published: June 11, 2018
C3orf21 (chromosome 3 open reading frame 21), also known as xyloside xylosyltransferase 1 (XXYLT1), is located on chromosome 3q29. C3orf21 belongs to the glycosyltransferase 8 family, furthermore, it is a retaining glycosyltransferase. In the extracellular domain of target proteins, XXYLT1 catalyzes addition of the second sylose, and then elongates the O-linked xylose-glucose disaccharide attached to EGF-like repeats. XXYLT1 negatively regulates Notch signaling, and aberrations in the Notch sign...
Open Access DOI:10.23937/2474-3690/1510031e
Brake Iron Dust Inhalation, Magnesium Deficiencies and Hypertension
William J Rowe
Article Type: Editorial Article | First Published: June 09, 2018
Armstrong returned with extraordinary diastolic hypertension (160/135) and Irwin, after his Apollo 15 mission, with blood pressure of 275/125 after only 3 minutes of exercise. Having supervised over 5000 symptom-limited maximum, treadmill hospital based stress tests, I have never seen such extraordinary blood pressure levels. I have shown that the invariable magnesium (Mg) deficiencies of space flight and dehydration with angiotensin and catecholamine elevations, leaking of plasma through defect...
Open Access DOI:10.23937/2572-3278.1510025
Absorption of Hydroxytyrosol from Different Sources and its Impact on Lipid Status in Human Subjects
Simone Siefer, Roland Wacker, Manfred Wilhelm and Christiane Schoen
Article Type: Research Article | First Published: June 09, 2018
There is growing interest in the health effects of dietary polyphenols on cardiovascular risk factors. In this context, the effect of hydroxytyrosol on lipid status was investigated in healthy subjects. Hydroxytyrosol, a polyphenol especially known from olive oil, is available on the market from different sources. Absorption from those sources is prerequisite for its effects....
Open Access DOI:10.23937/2572-3286.1510036
Alport Syndrome: No Evidence of Improved Prognosis in Modern Era
Kelly YP, Wallis L, Patil A, Murray S, Kant S, Kaballo M5, Casserly L, Doyle B, Dorman T, O'Kelly P and Conlon PJ
Article Type: Research Article | First Published: June 09, 2018
Alport syndrome is an inherited renal disease, first described in 1927, which is characterized by haematuria, renal failure, hearing loss, lenticonus, retinal flecks, a lamellated glomerular basement membrane and mutations in the COL4A5 or COL4A3/COL4A4 genes leading to abnormal Type IV collagen composition. The prevalence of the disease is estimated at 1 in 50,000 live births....
Open Access DOI:10.23937/2469-5718/1510091
Changes in Lifestyle, Exercises, Possible Mechanisms and Associations with Prostate Cancer
Mauro Sergio Perilhao, Roberta Luksevicius Rica and Danilo Sales Bocalini
Article Type: Review Article | First Published: June 09, 2018
Prostate cancer is characterized by overgrowth of the prostate, followed by a decrease in the size and intensity of the urinary stream, which is considered a major cause of illness and death worldwide. Its etiology is unknown. Physical activity and sedentary lifestyles are placed in the context of lifestyle, which has been studied since researchers realized that changes in one's living influence the onset of prostate cancer....
Open Access DOI:10.23937/2572-4193.1510043
Middle Ear Pressure Changes Over Time in Children with Down Syndrome
Scott Mitchell, Matthew JV Holmes and Nicholas Turner
Article Type: Research Article | First Published: June 08, 2018
Down syndrome is one of the most common genetic conditions affecting approximately 1 in every 1000 live births. There are a multitude of potential clinical manifestations associated with this condition including dysmorphic features, organic disorders such as congenital cardiac defects, gastrointestinal defects, ocular abnormalities, celiac disease and endocrine disorders along with haemato-oncological, immunological and disorders affecting the ears, nose and throat....
Open Access DOI:10.23937/2469-5750/1510055
Cutis Laxa of the Face: A Case Report and Review of Literature
Misani M and de Fontaine S
Article Type: Case Report | First Published: June 08, 2018
Cutis laxa is a rare disorder of the connective tissue, characterized clinically by loose, pendulous and inelastic skin producing the appearance of premature aging. The histology is peculiar for loss of dermal elastic tissue. It may be inherited or acquired, both forms being generalized or localized. The acquired localized form is very uncommon and is usually preceded by inflammatory lesions....
Open Access DOI:10.23937/rmi-2017/1710002
Does Luteal Phase Deficiency Exist and What is its Association with Infertility?
Monica S Chung, Laurice Bou Nemer and Bruce R Carr
Article Type: Mini Review | First Published: June 06, 2018
Luteal Phase Deficiency (LPD), also known as luteal phase defect, is a concept that was defined by Georgeanna Seegar Jones in 1949 as reduced progesterone production by the Corpus Luteum (CL). LPD results from low endogenous progesterone production and the resultant insufficiency to maintain a secretory endometrium to allow embryo implantation and growth....