Open Access DOI:10.23937/2378-3001/1410074
The Main Neurological Dysfunctions in Hyperargininemia-Literature Review
Andre Eduardo Almeida Franzoi, Marcelo Manukian Patti, Debora Delwing Dal Magro and Daniela Delwing de Lima
Article Type: Original Article | First Published: June 25, 2018
Arginine is an essential amino acid. This compound plays an important role in various body functions including cell division, wound healing, removal of ammonia, immune function, and release of hormones. The arginase 1 is a hepatic enzyme that is the faulty component in urea cycle. The urea cycle is represented in Figure 1 with focusing on arginine. When in normal function, the enzyme catalyzes the reaction of conversion of the arginine in ornithine and urea. However, in hyperargininemia, this en...
Open Access DOI:10.23937/iamm-2017/1710003
Potential of Carcinogenesis Induced by John-Cunningham Virus and Crude-Oil Extracts
Shih-Chao Lin, Christopher Z Lien and Chi-Chen Lin
Article Type: Short Communication | First Published: July 13, 2018
John-Cunningham virus (JCV) has been recognized as a major contributor to progressive multifocal leukoencephalopathy (PML) in humans, especially in immunodeficient patients. While the prevalence rate of PML in human populations could be up to 80%, the occurrence of tumorigenesis is around 0.07%. Thus, we investigated whether crude-oil extracts could synergistically increase the carcinogenesis along with T antigen from JC virus in vitro. Here we analysed the cell cycle distribution and cytotoxici...
Open Access DOI:10.23937/2378-3516/1410081
Tuberculosis Diagnosis in Private Independent Laboratories in Kampala- Uganda Implications for TB Control in the City
D Lukoye, D Okello, S Namatovu, A SSebagereka, K Mutesasira, Mabumba Eldad, M Nandala and P Suarez
Article Type: Research Article | First Published: July 13, 2018
Tuberculosis remains the greatest killer globally. Uganda, one of the highest TB burden countries has a rapidly growing private medical sector. Although a large proportion of patients first seek care from the private sector, there is very little if any literature about participation of private independent laboratories in diagnosis of TB. We aimed at assessing this and the extent to which diagnosed TB patients are linked to care....
Open Access DOI:10.23937/2572-4193.1510045
Silent Sinus Syndrome: A Case Report and Review of Literature
Sumana CV and Suhel Hasan
Article Type: Case Report | First Published: July 12, 2018
Silent sinus syndrome is a rare clinical entity affecting the maxillary sinus, causing progressive enophthalmos and hypoglobus resulting from retraction of maxillary sinus walls with increase in the orbital volume. We report a case of a 29-year-old male who presented with painless enophthalmos, without any disturbances in vision or ocular movements, with no history of sinusitis in the past....
Open Access DOI:10.23937/2469-5769/1510035
Congenital Cytomegalovirus Infection Presenting as Severe Conjugated Hyperbilirubinemia on First Day of Life
Aaradhana Singh and Ravi Sachan
Article Type: Case Report | First Published: July 12, 2018
Congenital Cytomegalovirus infection (CMV) has varied presentations ranging from asymptomatic to involvement of multiple organ systems like central nervous system, gastrointestinal, hepatic and hematopoietic. Jaundice is a manifestation of congenital CMV presenting as neonatal hepatitis or cholestasis jaundice. We report a case of severe conjugated hyperbilirubinemia presenting on the first day of life that was diagnosed as a case congenital CMV on further workup....
Open Access DOI:10.23937/2377-9004/1410127
High Grade Uterine Sarcoma with Concurrent Metastatic Adenocarcinoma to the Uterus: A Case Report
Luke King, Radhika P Gogoi, Christopher Hummel, Zongming Chen and Ashlee Smith
Article Type: Case Report | First Published: July 12, 2018
A 59-year-old G1P1001 with a past medical history of hypertension, benign thyroid nodules, class III obesity (body mass index 35.02 kg/m2) and appendectomy with colonic resection due to intussusception as a child, presented for gynecologic consultation for a large uterine mass found on transvaginal ultrasound following a 2-month history of lower abdominal pain, vaginal bleeding, and malodorous vaginal discharge....
Open Access DOI:10.23937/2469-5793/1510080
Liver Metastases from Gists
Gargantilla Pedro, Martin Berta and Pintor Emilio
Article Type: Case Report | First Published: July 12, 2018
Gastrointestinal Stromal Tumors (GISTs) are rare tumors of the gastrointestinal tract, with an estimated incidence of 1.5/100000/year. GISTs are nonepithelial tumors originating in the interstitial Cajal's cells (cells of the autonomic nervous system). These cells express antigens for CD 177 and/or CD 34....
Open Access DOI:10.23937/2469-5793/1510079
Rapidly Enlarging Thyroid Mass
Gargantilla Pedro, Martin Berta and Pintor Emilio
Article Type: Short Communication | First Published: July 11, 2018
An 83-year-old man come to our observation because of a rapidly enlarging anterior neck mass at the last two weeks, dysphagia, dysphonia and neck pain. Patient didn't mention about previous irradiations on the neck either familiarity with thyroid and neoplastic diseases. He had a past medical history of diabetes mellitus type 2. Physical examination revealed one palpable formation (7 × 5 cm) over the right lower neck....