Open Access DOI:10.23937/iaim-2017/1710006
Cutaneous Angiosarcoma in a Psoriasis Patient on Infliximab and Methotrexate Therapy
Annika Silfvast-Kaiser, Amanda Abramson Lloyd and Alan Menter
Article Type: Case Report | First Published: October 12, 2018
Angiosarcoma is a soft tissue sarcoma of endothelial origin that can arise in any organ, with an incidence of up to 5% of all malignant cutaneous tumors. It is the 4th most common sarcoma of the skin and typically occurs on the scalp of white men over 60 years of age. Its prognosis is traditionally very poor, with 5-year survival rates reported as low as 11%. Risk factors for cutaneous angiosarcoma have not been clearly established. Herein, we describe a 64-year-old male with a chronic history o...
Open Access DOI:10.23937/2572-3235.1510038
The Role of the Diffusion Tensor Imaging and the MR Tractography in the Evaluation of the Ischemic Cerebral Strokes
Ahmed H Farahat, Mervat E Lgohary and Hany Hafez
Article Type: Research Article | First Published: October 12, 2018
Cerebral stroke is a worldwide concern, it's classified as the most second cause of death in 2008. In this year 5.7 million deaths and about nine million patients had cerebral strokes events with resultant variable degrees of disabilities. The primary goal in stroke management is to reach an early accurate diagnosis for the patients, which will affect the choice of the treatment lines among the newly developed programs and the end stage recovery. The DTI & DTT are MRI techniques used for the 3D ...
Open Access DOI:10.23937/2469-5807/1510078
Liver Fibrosis Quantification by Digital Whole Slide Imaging and Two Photon Microscopy with Second Harmonic Generation
Jolanta Jedrzkiewicz, Mary P Bronner, Mohamed E Salama, Jessica Kohan, Leslie R Rowe, Dean Tai, Elisabeth Malmberg and Erinn Downs-Kelly
Article Type: Original Article | First Published: October 12, 2018
The progression of fibrosis in liver disease is the single most important pathologic process guiding patient prognosis and treatment decisions. Unfortunately, its histologic assessment is subjective, descriptive and non-quantitative. A more objective and uniform method is needed to assess fibrosis in order to optimize patient care. To that end, we employed two new quantitative imaging technologies to evaluate fibrosis....
Open Access DOI:10.23937/2469-5807/1510077
Gastric Composite Tumor: A Mixed Adenocarcinoma and Neuroendocrine Tumor with Goblet Cell Carcinoid Component
Archana Lakshmanan, Ann Kurian and Annapurneswari Subramanyan
Article Type: Case Report | First Published: October 12, 2018
Goblet cell carcinoids are distinct neoplasms with combined histologic features of carcinoid and adenocarcinoma with the intermediate prognosis. They are initially thought to arise only from the appendix, however, in the recent past, a few cases have been described in extra appendiceal locations. Mixed adenoneuroendocrine tumors of the stomach are uncommon and that including Goblet cell carcinoid component is exceedingly rare. We report a case of composite tumor involving the stomach with four d...
Open Access DOI:10.23937/2469-5807/1510076
Hodgkin Lymphoma Involving the Oesophagus: A Case Report
Ban Sulaiman, Iram Naaz and Anne Crotty
Article Type: Case Report | First Published: September 29, 2018
Lymphomas of the gastrointestinal tract are very rare. Primary and secondary oesophageal lymphoma account for less than 1% of all gastrointestinal lymphomas. Secondary oesophageal involvement is by contiguous spread from the stomach or surrounding lymph nodes. Patients with oesophageal lymphoma have varying presentations and complications which include perforation with a tracheo-oesophageal fistula, mass and haemorrhage....
Open Access DOI:10.23937/2378-3001/1410077
Cerebral Histoplasmosis in Non-Immunosuppressed Patient - Case Report
Andre Eduardo de Almeida FRANZOI, Nayme Hechem MONFREDINI, Leonora Zozula Blind POPE, Felipe Ibiapina dos REIS and Fabio Antonio TIRONI
Article Type: Case Report | First Published: October 12, 2018
Histoplasmosis is a disease caused by Histoplasma capsulatum var. capsulatum, which is endemic in Latin America. The manifestation of the disease in the central nervous system (CNS) is more frequent in immunosuppressed individuals with disseminated presentation. Pulmonary manifestations are usually the first symptoms. However, when neurological manifestations are the first clinical manifestations, the diagnosis becomes a challenge. The early diagnosis is fundamental in the final outcome of the p...
Open Access DOI:10.23937/2378-3001/1410076
Dementia with Lewy Bodies and Parkinson's Disease-Dementia: Current Perspectives
Kurt A Jellinger
Article Type: Review Article | First Published: October 12, 2018
Dementia with Lewy bodies (DLB) and Parkinson's disease-dementia (PDD) are two closely related major neurocognitive disorders with Lewy bodies of unknown etiology, showing notable overlap in their clinical presentation, pathological features, biochemistry, and genetic risk factors. According to international consensus, their diagnosis is based on an arbitrary distinction between the time of onset of motor and cognitive symptoms: dementia preceding parkinsonism in DLB, while it develops after ons...
Open Access DOI:10.23937/2378-3672/1410032
Analysis of Membrane Antigens on Neutrophils from Patients with Pneumonia
Shigeru Tansho-Nagakawa, Tsuneyuki Ubagai, Yoji Koshibu, Takane Kikuchi-Ueda, Ryuichi Nakano, Go Kamoshida, Hirotoshi Kikuchi, Hiroto Ikeda, Yasuyuki Uchida, Tetsuya Sakamoto and Yasuo Ono
Article Type: Original Article | First Published: October 12, 2018
The aim of the present study was to assess the changes in cell membrane antigens on neutrophils from peripheral blood obtained from patients with pneumonia. Neutrophils play an important role in the phylaxis against pneumonia caused by bacteria and fungi. The recruitment of neutrophils to the lungs is a multistep process that involves granulopoiesis, neutrophil release, expression of neutrophil chemoattractants and cellular adhesion molecules, and the eventual transmigration of neutrophils into ...
Open Access DOI:10.23937/2378-3672/1410031
pTregs or iTregs are the Potent Tolerance Inducer for the growth and Metastasis of Cancer
Upendra P Hegde, Evan R Jellison and Nitya G Chakraborty
Article Type: Research Article | First Published: October 11, 2018
It remains a wonder how Tregs induce tolerance for the development of cancer. Previously we have shown with melanoma patients that, increase in peripherally induced Tregs (pTregs) number in blood is related to the poor prognosis of the disease. In vitro induced Tregs (iTregs) and pTregs are remarkably similar and significantly different in functionality from tTregs. Here, we worked with 12 melanoma patients- six HLA A2 positive and six HLA A2 negative. PBL and tumor cells were obtained from the ...