Open Access DOI:10.23937/2469-5718/1510111

Effect of Blood Flow Restriction Training in Combination with a High-Intensity Interval Training on Physical Performance

Alexander Torpel, Marie Brennicke, Maximilian Kuck, Tom Behrendt and Lutz Schega

Article Type: Research Article | First Published: December 12, 2018

We aimed to investigate whether a Blood Flow Restriction Training (BFR) prior to a High Intensity Interval Training (HIIT) leads to a higher increase in physical performance than a sole HIIT. 24 male participants (18 to 30 years) were randomly assigned to a BFR+HIIT or HIIT group which performed 3 times per week over 4 weeks a HIIT on bicycle-ergometers. Prior to each training session of the HIIT, both groups carried out 4 sets of deep squats without additional load but the BFR+HIIT group perfor...

 Open Access DOI:10.23937/2469-5718/1510110

Isokinetic Force and Work Capacity after Long-Duration Station «MIR» and Short-Term International Space Station Missions

Yuri A Koryak

Article Type: Research Article | First Published: December 12, 2018

The effects of long-duration (~ 210 days) aboard the Orbital Station "MIR" and short-term (~ 10 days) spaceflights aboard the International Space Station on the joint torques of various muscles and work capacity of knee extensors were studied in male cosmonauts. Greater postflight changes in maximal joint torque were observed for back, knee, and ankle extensors compared with flexors, and the difference was especially clearly seen after long-term spaceflights. Muscle work capacity was inferred fr...

 Open Access DOI:10.23937/ijda-2017/1710009

Sleep Quality in Osteoporotic Elderly: Relationship to Pain Sensitıvity and Depression

Kasapoglu Aksoy M, Aykurt Karlibel I, Dulger S and Altan L

Article Type: Research Article | First Published: December 12, 2018

The objective of the current study was to assess the impact of sleep quality on pain sensitivity and depressive symptoms in the elderly. In this cross-sectional analytical design study a total of 78 patients (65-85 years) with good general health status and 44 young (30-50 years) healthy volunteers were included. All subjects assessed by Pittsburg sleep quality index (PSQI), pain pressure threshold (PPT) and geriatric depression scale (GDS)....

 Open Access DOI:10.23937/2378-3648/1410041

Identification of the Single Nucleotide Polymorphisms Affecting Normal Phenotypic Variability in Human Craniofacial Morphology Using Candidate Gene Approach

Mark Barash, Philipp E Bayer and Angela van Daal

Article Type: Research Article | First Published: December 08, 2018

There is a remarkable variety of human facial appearances, almost exclusively the result of genetic differences, as exemplified by the striking resemblance of identical twins. Despite intensive research on the genetics of craniofacial morphology using animal models and human craniofacial syndromes, the genetic variation that underpins normal human facial appearance is still largely elusive....

 Open Access DOI:10.23937/2469-567X/1510045

Time to Major Adverse Reactions of Anti-Retroviral Drugs and its Predictors among Cohort of Patients Receiving Antiretroviral Therapy in Hosanna Hospital, Hosanna, Ethiopia: Retrospective Cohort Study

Likawunt Samuel Asfaw and Fikre Enquselassie

Article Type: Original Research | First Published: December 08, 2018

Antiretroviral therapy (ART) suppresses viral reproduction and stop progression of the disease process. Antiretroviral drug adverse reactions negatively influence antiretroviral treatment outcome. Incidence, type and time antiretroviral drug adverse reactions occur is not well documented. The purpose of this study was to investigate time to major antiretroviral drugs adverse reactions and its predictors among patients receiving ART in Hosanna, Ethiopia....

 Open Access DOI:10.23937/2377-4630/1410082

Efficacy and Safety of the Intraosseous Vascular Access in out-of-Hospital Emergencies: A Prospective Study of the Pre-Hospital Emergency Service (SUEM 118) of Padua from 2012 to Today

Andrea Paoli, Marco Lorenzini, Annalisa Boscolo, Andrea Spagna and Carlo Ori

Article Type: Research Article | First Published: December 06, 2018

Several scientific associations recommend the use of the intraosseous access as a valid alternative to the intravenous route, which is often difficult to find in emergency conditions, as a safe and effective way for drugs and fluids administration and for blood sampling. Rapid intravascular access is of paramount importance in both in and out-of-hospital emergency care. Quick treatment of medical and traumatic situations, along with correct resuscitation maneuvers, can decrease the mortality and...

 Open Access DOI:10.23937/2469-570X/1410056

Mechanical Stimulation Increases the Proliferation and Differentiation Potential of Human Adipose-Derived Stromal Cells

Susanne Jung, Lauren Bohner, Kathrin Spindler, Marcel Hanisch, Johannes Kleinheinz and Sonja Sielker

Article Type: Original Article | First Published: December 05, 2018

Dynamic conditions stimulate the bone remodeling process by improving the nutrients transport and increasing the expression of osteogenic cells. The purpose of this study was to evaluate the effect of mechanical stimulation on the osteogenic differentiation of human adipose-derived stromal cells. Bone fracture defects require an interventional treatment which is dependent from the size of the injured site: Whereas smaller bone defects may be spontaneously solved and comprise minimal intervention...

 Open Access DOI:10.23937/2378-3664.1410026

Pharmaceutical Particle Engineering via Nano Spray Drying - Process Parameters and Application Examples on the Laboratory-Scale

Arpagaus Crpagaus

Article Type: Review Article | First Published: December 05, 2018

Spray drying plays a crucial role in the processing of pharmaceutical products such as pills, capsules, and tablets as it is used to convert drug-containing liquids into dried powdered forms. Nano spray drying is in particular used to improve drug formulation by encapsulating active ingredients in polymeric wall materials for protection and delivering the drugs to the right place and time in the body. The nano spray dryer developed in the recent years extends the spectrum of produced powder part...

 Open Access DOI:10.23937/2377-3634/1410098

Insulin Acts as Stimulatory Agent in Diabetes-Related Escherichia Coli Pathogenesis

amelija Madacki-Todorovic, Izet Eminovic, Nadira Ibrisimovic Mehmedinovic and Mirza Ibrisimovic

Article Type: Research Article | First Published: December 05, 2018

In general, diabetic patients are more prone to microbial infections, which is believed to be caused due to high glucose levels in blood which compromise components of the immune system. However, it is little known about role of therapeutic insulin administration on dissemination of infectious diseases in people with diabetes mellitus. The study included the clinically isolated strains of Escherichia coli (E. coli) with biofilm forming capacity as well as referent non-biofilm former E. coli stra...

 Open Access DOI:10.23937/2378-2951/1410131

The Profile of an Adult with Congenital Heart Disease

John Jairo Araujo

Article Type: Short Review | First Published: December 01, 2018

Congenital heart disease is the most frequent malformation. In the most recent data has a prevalence of thirteen cases per 1,000 children and six cases per 1,000 adults. Great strides in pediatric cardiovascular surgery have increased the number of survivors, especially in adulthood. Nowadays more adults are living with congenital heart disease than children, particularly in developed countries, and more than two thirds fall into the categories of moderate and high complexity defects. This growi...