Open Access DOI:10.23937/2474-3658/1510075
A Risk Factor Analysis for MRSA Ventilator-Associated Pneumonia to Guide Empiric Therapy in the Surgical Intensive Care Unit
Megan E Feeney, PharmD, BCCCP, David E Lindsey. MD, Daniel E Vazquez, MD, Kyle Porter, MAS and Claire V Murphy, PharmD, BCPS, FCCM
Article Type: Research Article | Publication Updated: April 05, 2019
Methicillin resistant Staphylococcus aureus (MRSA) ventilator-associated pneumonia (VAP) is increasing in prevalence. Treatment of VAP has moved toward ensuring patients are adequately covered for MRSA and other MDROs while balancing the need for antimicrobial stewardship and appropriateness of empiric coverage of these organisms in the setting of increasing resistance rates. The objective of this study was to identify the incidence of and risk factors for MRSA VAP in surgical intensive care uni...
Open Access DOI:10.23937/NCR-2017/1710013
Self Manipulated Cervical Spine Leads to Posterior Disc Herniation and Spinal Stenosis
Wyatt McGilvery, BS, Marc Eastin, MD, Anish Sen, MD and Maciej Witkos, MS, MD
Article Type: Case Report | Publication Updated: April 05, 2019
The authors report a case in which a 38-year-old male who presented himself to the emergency department with a chief complaint of cervical neck pain and paresthesia radiating from the right pectoral region down his distal right arm following self manipulation of the patient's own cervical vertebrae. Initial emergency department imaging via cervical X-ray and magnetic resonance imaging (MRI) without contrast revealed no cervical fractures; however, there was evidence of an acute cervical disc her...
Open Access DOI:10.23937/2469-5734/1510085
Diagnosis, Prevention and Treatment of White Spot Lesions Related to Orthodontics
Sitki Sarper Temel and Burcak Kaya
Article Type: Review Article | Publication Updated: April 05, 2019
The purpose of this review article is to examine the etiology, incidence and classification of white spot lesions in association with their prevention and treatment methods. White spot lesions are opacities that occur by demineralization of enamel under the surface and cause esthetic problems. Orthodontic treatment increases the risk of white spot lesion occurrence by creating areas difficult to clean and prone to plaque accumulation around orthodontic attachments. Therefore, application of suit...
Open Access DOI:10.23937/2377-4630/1410087
Spinal Anesthesia for Emergent Testicular Torsion Surgery in a Pediatric Patient with Spinal Muscular Atrophy Type-II
Hande Gurbuz Aytuluk and Hulya Topcu
Article Type: Case report | Publication Updated: April 05, 2019
Spinal muscular atrophy (SMA) is one of the most common inherited diseases in children. The clinical symptoms of this neuromuscular disease vary widely from muscle weakness to death according to the onset of symptoms. There is no specific treatment for the disease. There are many risks for anesthesia, as these patients usually have skeletal deformities, increased sensitivity to opioids and neuromuscular blockers, and pulmonary disease secondary to respiratory muscle dysfunction. There is no evid...
Open Access DOI:10.23937/2474-1353/1510091
HR-MRI of the Breast at Intervals of Maximum 24 Months: Influence on Tumor Stage at the Time of Diagnosis
Uwe Fischer, M Hollstein, S Luftner-Nagel, F Baum and S Wienbeck
Article Type: Original Article | Publication Updated: April 04, 2019
Tumor size, the histology and immunhistochemical parameters as well as the lymph node status at the time of diagnosis have a relevant influence on the prognosis and the long time-survival of breast cancer. In this context, invasive carcinomas under 10 mm in size, which most often exhibit a N0-lymph node status, have an excellent 10-year-tumor-free survival rate of 98%. With respect to intraductal breast tumors, this rate increases to 100% if adequate therapy is performed. Self-examination and me...
Open Access DOI:10.23937/IJTD-2017/1710019
Plasmodium falciparum Infection among Febrile Patients Attending a Tertiary Healthcare Facility in Central Nigeria: Prevalence, Hematologic and Sociodemographic Factors
Yohanna Jemimah, Oti Victor, Amuta Elizabeth, Philip Akpu and Anizoba Lynda
Article Type: Research article | Publication Updated: April 04, 2019
Plasmodium falciparum infection remains a leading cause of global morbidity and mortality, causing about 3,000 daily deaths. This study intended to document the prevalence, and the associated factors of P. falciparum infection among febrile patients attending Federal the Medical Centre Keffi, Nigeria. After ethical clearance, 400 whole blood samples were collected from patients who gave informed consent and completed a self-structured questionnaire from July 2015 through January 2016. The blood ...
Open Access DOI:10.23937/2469-5696/1410038
MEK1/2 as a Therapeutic Target in Sickle Cell Disease
Rahima Zennadi
Article Type: Short review | Publication Updated: April 04, 2019
Identification of novel therapeutic targets has improved diagnostics and treatment of many diseases. Many innovative treatment strategies have been developed based on the newly identified biomarkers and key molecules. Most of the research focused on ways to manipulate signaling pathways by activating or suppressing them, validate new therapeutic targets for treatment, and epigenetic treatment of diseases. With the identification of aberrations in multiple growth pathways, the focus then shifted ...
Open Access DOI:10.23937/2378-3516/1410104
Forced Mid-Expiratory Flow Can Predict Ventilatory Limitation and Exercise Capacity
Mandeep Hundal, Christian Ghattas, Lori Lyn Price, Peter Lacamera and John Unterborn
Article Type: Original Research Article | Publication Updated: April 03, 2019
Exercise limitation associated with most lung diseases is multifactorial and is due to complex interactions between impaired ventilatory, cardiovascular, and peripheral muscle responses. Cardiopulmonary exercise tests (CPETs) are often required to ascertain the primary cause of exercise limitation particularly in patients with multiple co-morbidities. CPETs are generally offered only at tertiary care medical centers. To evaluate if forced expiratory flow from 25% to 75% of vital capacity (FEF25-...
Open Access DOI:10.23937/2378-2951/1410142
Long-Term Clinical and Echocardiographic Outcome in Patients with CRT and Functional Mitral Regurgitation: MitraClip versus Optimal Medical Therapy
Arianna Cirasa, MD, Antonio Popolo Rubbio, MD, Paolo Zappulla, MD, Angelo Di Grazia, MD, Daniela Dugo, MD, Salvatore Scandura, MD, Sarah Mangiafico, MD, Carmelo Grasso, MD, Corrado Tamburino, MD, PhD, Davide Capodanno, MD, PhD and Valeria Calvi, MD, PhD
Article Type: Research Article | Publication Updated: April 03, 2019
This study sought to evaluate the clinical outcome in cardiac resynchronization therapy (CRT) patients with residual moderate-to-severe functional mitral regurgitation (FMR) who underwent percutaneous treatment with the Mitraclip System or were managed with medical therapy alone. Significant FMR can persist in 20-25% of patients after CRT and its management can be a challenge, due to the advanced heart failure (HF) and a variety of concomitant comorbidities. From a single center, two different g...