Open Access DOI:10.23937/2378-3516/1410105

Determination of Epidermal Growth Factor Receptor (EGFR), KRAS and BRAF Mutation in Non Small Cell Lung Cancers Using Biofilm Chip Based Microarray Technology

Ozlem Ceren Gunizi, Gulay Ozbilim and Mualla Ozcan

Article Type: Research Article | First Published: April 26, 2019

Of the 96 patients included in the study, 58 were adenocarcinomas, 30 were squamous cell carcinomas (SCC), and 8 were large cell neuroendocrine carcinomas (LCNEC). While EGFR mutation was detected in 14 (24.1%) of the adenocarcinoma patients, KRAS mutation was detected in 12 (20.6%) patients. BRAF mutation was observed in 1 patient with adenocarcinoma (1.7%). KRAS mutation was observed in only 1 of the SCCs (3.3%). KRAS mutation was observed in 1 of the LCNECs (12.5%). EGFR mutation in adenocarc...

 Open Access DOI:10.23937/2469-5742/1510056

Using Modified Clavien-Dindo's Classification System for Reporting Postoperative Complications of Transvesical Prostatectomy at Souro Sanou University Teaching Hospital of Bobo-Dioulasso (Burkina-Faso)

Adama Ouattara, Abdoul Karim Pare, Aristide F Kabore, Boukary Kabre, Amidou Bako and Mickael Rouamba

Article Type: Research Article | First Published: April 26, 2019

Hundred patients (100) presenting a complication after BPH surgery were included in this study in a total of 312 open prostatectomies performed. The post-operative complication rate was 32%. Seventy percent of the patients had at least one complication. Grade I and Grade II complications according to the modified Clavien's classification system were the most represented (87%). Two patients (2) died in the immediate postoperative period (Grade V). The presence of urethral catheter before surgery ...

 Open Access DOI:10.23937/2572-3278.1510034

Behavioral Factors Associated with Adherence to the Mediterranean Diet in Young University Students - A Cross-Sectional Study

Elena Hadjimbei, George Botsaris, Vassilis Gekas and Andrie G Panayiotou

Article Type: Research Article | First Published: April 25, 2019

Adherence to the Mediterranean diet was found to be average for the majority of young adults, with 21.8% being classified as low adherers, and 26.9% as high adherers. A higher health habit score was associated with higher adherence to the Mediterranean diet (0.614 higher average adherence (95% CI: 1.07 to 1.55) for one unit change in health habit score). About 63% of students reported consuming breakfast on a regular basis, while half consumed three or fewer meals per day. The main person respon...

 Open Access DOI:10.23937/2469-5718/1510126

Effects of Multicomponent Training on Functional Fitness and Quality of Life in Older Women: A Randomized Controlled Trial

Antonio Gomes de Resende Neto, Matheus Amarante do Nascimento, Danilo Rodrigues Pereira da Silva, Raquel Simoes Mendes Netto, Josimari Melo de Santana and Marzo Edir Da Silva Grigoletto

Article Type: Research Article | First Published: April 25, 2019

Sixty-two older women were randomized into a multicomponent group (MG: n = 32, 65.28 ± 4.96 years) or a stretching group (SG: n = 32, 64.40 ± 3.68 years). MG performed joint mobility exercises, walking, muscle strength exercises and intermittent activities. SG has performed flexibility exercises with minimal physical effort. In order to verify the functional fitness, the Senior Fitness Test battery was used and the quality of life was verified by means of the WHOQOL BREF questionnaire in the p...

 Open Access DOI:10.23937/2378-3419/1410112

Common Factors among Some of the Reported Cases of the Spontaneous Remission and Regression of Cancer after Acute Infections

Behzad Niakan, Pharm D

Article Type: Hypotheses | First Published: April 25, 2019

An immunological mechanism has been suggested for the case reports of the spontaneous remission of cancer after an acute infection. The basic suggestion made is that a few acute inflammatory responses are occurring at about the same time in these cancer patients. Furthermore, it is suggested that a few acute inflammatory responses occurring at about the same time may negate the inhibitory effect of systemic inflammation on innate immunity. It is suggested that the activation of innate immunity c...

 Open Access DOI:10.23937/2469-5777/1510072

STEMI due to Severe Blunt Chest Trauma

Joseph Shiber, MD, FACP, FACEP, FCCM, David Skarupa, MD, FACS and Timothy Hester, DO

Article Type: Case Report | First Published: April 24, 2019

A 50-year-old man was ejected during an ATV collision. On arrival to the trauma center, he was endotracheally intubated for hypoxemic respiratory distress and was noted to have palpable subcutaneous air and decreased breath sounds; thoracostomy tubes were placed bilaterally. New-onset atrial fibrillation with rapid ventricular response (heart rate > 160) was found with ST-segment elevation most pronounced in Inferior leads (Figure 1) Chest radiograph confirmed severe right-sided pulmonary contus...

 Open Access DOI:10.23937/2377-9004/1410145

Uterine Leiomyoma with Lung Metastases Stump Tumour

Martin N, Escobar A, Varela A, Guillem E and Cortes-Funes H

Article Type: Case Report | First Published: April 24, 2019

We present one clinical case of a 41-year-old, female Russian origin patient, with lung nodules suggestive of metastases, with no primary tumor found, referred for study and treatment in our Oncology Department. After a deep analysis of the case, reviewed the literature and result of the pathology of biopsy from lung lesions, the final diagnosis reached was: Benign muscle tumors of Gynecological origin, with the capacity for produce distant metastasis compatible with STUMP Tumor (Metastatic leio...

 Open Access DOI:10.23937/2469-5858/1510068

Improvement in Nutritional Status is Associated with Achieving an Adequate Gait Speed at Discharge in Elderly Patients Hospitalized with Acute Heart Failure

Satoru Sakuragi, Nobuhisa Kodera, Toshihiro Iida, Takashi Yamada, Mitsutaka Nakashima, Atsushi Mori, Yuji Koide, Tadashi Wada, Kenji Kawamoto, Machiko Tanakaya and Yusuke Katayama

Article Type: Original Article | First Published: April 24, 2019

Elderly patients have impaired physical function, which is further reduced by the incidence of hospitalization for heart failure. In these patients, nutritional status also deteriorates during hospitalization, which may cause impairment in their physical function. In this study, we repeatedly measured physical function using gait speed (GS) during hospitalization, and evaluated the factors including nutritional status that are associated with GS at discharge in elderly patients with acute heart ...

 Open Access DOI:10.23937/2474-1353/1510094

Unmasking Hidden Recurrent Cancers using FMTVDM/BEST: The Fleming Cancer Hypothesis

Richard M Fleming, PhD, MD, JD, Matthew R. Fleming, BS, Tapan K Chaudhuri, MD, William C Dooley, MD and Andrew McKusick, BS Pharm

Article Type: Commentary | First Published: April 24, 2019

Prior to FMTVDM/BEST Imaging, diagnostic testing was limited to looking for breast cancer either using "qualitative" imaging defining disease as being present or absent, or semiquantitative methods which are also limited to the same yes you have breast cancer or no you don't interpretation. These imaging methods include mammography, ultrasound, CT, MRI, as well as other SPECT/Planar and PET imaging approaches and as such are associated with sensitivity and specificity problems. These tests are f...

 Open Access DOI:10.23937/2469-5769/1510053

A Questionnaire Survey on Parent's Awareness Regarding Childhood Neurodevelopmental Disorder

Bishnu Prasad Mandal, Yao Yang and Jingyi Fan

Article Type: Research Article | First Published: April 24, 2019

Neurodevelopmental disorders (NDDs) are growing worldwide in both developed and developing countries. Parents are primary caregivers to recognize the signs and symptoms of children's behavior or mental -illness. This study is to obtain basic knowledge and awareness about NDDs in children in Nepali community. People in Nepali community have various religions and outdated belief. This study analyzes misconceptions and factors that influence the knowledge regarding NDDs among general populations, w...