Open Access DOI:10.23937/2572-4045.1510052
Covid-19 Pneumonia in Bilateral Lung Transplant Recipient: Case Report
Juan Pablo Reig Mezquida, MD, Alilis Fontana Bellorín, MD, Alberto Garcia Ortega, MD and Gabriel Anguera de Francisco, MD
Article Type: Case Report | First Published: May 18, 2020
The clinical course of Coronavirus disease 2019 (covid-19) in lung transplant recipients remains unknown. We present the fatal clinical course of a 63-year-old double lung transplant recipient with severe Covid-19 pneumonia. She had stable graft function before Covid-19 infection. Despite all the supportive care and treatment graft injury progressed, causing patient death. Therefore, the prognosis in lung transplant recipients with Covid-19 infection is not optimistic....
Open Access DOI:10.23937/2469-5734/1510108
Review: Differential Diagnosis of Drug-Induced Gingival Hyperplasia and Other Oral Lesions
Einhorn Omer Moshe
Article Type: Review Article | First Published: May 04, 2020
Chronic medication usage is a major component of the medical diagnosis of patients. Nowadays, some of the most common diseases such as cancer, hypertension, diabetes and etc., are treated with drugs which cause a variety of oral side-effects including gingival over growth and appearance of lesions on the tissues of the oral cavity. As such, drug-induced oral reactions are an ordinary sight in the dental practice. This review will point out the main therapeutic agents causing gingival hyperplasia...
Open Access DOI:10.23937/2474-3658/1510127
Epidemiological Trends, Characteristics, and Distribution of COVID-19: Lessons from SARS and MERS Outbreaks and Way Forward
Amen Bawazir, Nagarajkumar Yenugadhati, PhD, Omar B Da’ar and Hoda Jradi
Article Type: Commentary | First Published: May 22, 2020
Human infections with zoonotic coronaviruses became an emerging worldwide health concern. Previously Coronaviruses caused mild infections in immunocompromised people and were not considered to be highly pathogenic in humans until they circulated in the Guangdong province of China in 2002 and 2003 during the Severe Acute Respiratory Syndrome (SARS) outbreak. A decade following the aforementioned SARS outbreak, we witnessed the emergence of the Middle East respiratory syndrome coronavirus (MERSCoV...
Open Access DOI:10.23937/2474-3658/1510124
Shiga Toxin 2 Mediated Hemolytic Uremic Syndrome Complicated By Clostridium Septicum Bacteremia in a 4-Year-Old
Peter Paul Lim, MD, Christina Rae Nguyen, MD, Daniel Rhoads, MD and Arlene Dent, MD
Article Type: Case Report | First Published: May 21, 2020
Shiga toxin 2 (Stx2) is a potent toxin produced by shiga toxin-producing E. coli (STEC) that is commonly linked to development of hemolytic uremic syndrome (HUS). An extremely rare complication of shiga toxin associated (STEC) hemolytic uremic syndrome is concomitant infection with Clostridium septicum. The majority of pediatric patients with HUS complicated by C. septicum infection had complications including CNS involvement, severe renal insult often requiring hemodialysis, and myonecrosis war...
Open Access DOI:10.23937/2469-584X/1510073
Colonization of Lactobacilli among the Fecal Microflora of Healthy Iranian Breast-Fed Infants
Abolfazl Davoodabadi, Mohammad Mehdi Soltan Dallal, Maryam Tajabadi Ebrahimi and Zahra Rajabi
Article Type: Original Research | First Published: May 25, 2020
Lactobacilli are important bacteria among intestinal microflora. They can prevent intestinal colonization by pathogenic bacteria, and used as probiotics. The aim of this study was to investigate the rate Lactobacillus colonization in the fecal of healthy breast-fed infants. Fecal samples were collected from 90 healthy breast-fed infants under 18 months. Lactobacilli were identified by phenotypic and physiological methods. Carbohydrate fermentation patterns were determined using a miniplate metho...
Open Access DOI:10.23937/2378-3516/1410132
Rheumatoid Arthritis Associated Interstitial Lung Disease in KwaZulu-Natal, South Africa: A Retrospective 5-Year Review
Hosam Ghammo, Mohammed Mitha, Catherine Connolly and Kennedy Nyamande
Article Type: Research Article | First Published: May 25, 2020
The demographic distribution, symptom profile and treatment outcomes in Rheumatoid arthritis associated interstitial lung disease (RA-ILD) has not been well described in South Africa due to a paucity of data. The aim of the study was to determine the demographic profile of the disease, symptom and radiological presentation, as well as treatments used and their outcomes at Inkosi Albert Luthuli Central Hospital (IALCH), a specialised public government hospital treating the majority of patients wi...
Open Access DOI:10.23937/2643-4563/1710022
Assessment of Quality of Life in Radically Treated Head & Neck Cancer Patients: A Cross Sectional Study
Shekhar Kumar Keshri, MBBS, DMRT, MD, Satyendra Narayan Sinha, MBBS, DNB and Mitali Dandekar Lall, MBBS, MS, DNB
Article Type: Original article | First Published: May 20, 2020
Head and neck cancers pose a significant healthcare burden in India and more than two third of these patients present in advance stage. Multimodality treatment is recommended and often has detrimental impact on quality of life. A cross-sectional study was conducted from February-May 2019 among radically treated 73 head and neck cancer patients attending OPD for follow up using EORTC QLQ-C30 and QLQ H&N-35 questionnaires in Hindi language....
Open Access DOI:10.23937/2378-3672/1410049
Role of IL-17 and IL-23 in the Pathogenesis of Neutrophilic Asthma
Nightingale Syabbalo, MB, ChB, PhD, FCCP, FRS
Article Type: Review Article | First Published: May 21, 2020
Asthma is a complex chronic airway disease with several distinct phenotypes characterized by different immunopathological pathways, clinical presentation, physiology, comorbidities, biomarker of allergic inflammation, and response to treatment. Approximately 10% of patients with asthma have severe refractory disease, which is difficult to control on high doses of inhaled corticosteroids and other modifiers. About 50% of these individuals suffer from neutrophilic asthma. Neutrophilic asthma is a ...
Open Access DOI:10.23937/2469-5696/1410049
Heparin-Induced Thrombocytopenia Presenting as Splenic Hemorrhage Following Cardiac Surgery: A Case Report
J Ferry, S Youssef, P WU and L Hegerova
Article Type: Case Report | First Published: May 25, 2020
Heparin induced thrombocytopenia with thrombosis (HIT) is a paradoxical prothrombotic complication of anticoagulant therapy. We report a case of atraumatic splenic hemorrhage due to splenic vein thrombosis as main indicator to diagnosis of HIT. The presentation is reminiscent of the rare bilateral adrenal hemorrhage due to adrenal necrosis that occurs in HIT. Alternative anticoagulation is mainstay of therapy for HIT despite hemorrhage, given the underlying acquired hypercoagulability....