Open Access DOI:10.23937/2378-2951/1410192

Percutaneous Reversal of Cyanosis on Catheterization Table in a 12-Year-Old Boy using Cera Vascular Plug - A Case Report

Santosh Kumar Sinha, FACC, FAESC, FSCAI, Mahmodullah Razi, Umeshwar Pandey and Vinay Krishna

Article Type: Case Report | First Published: July 29, 2020

Pulmonary arteriovenous malformations are commonly treated by embolization with coils or balloons to prevent cerebral complications and to raise the oxygenation of the blood. The Cera vascular plug (Lifetech Scientific, Shenzhen, China) is a new vascular device made of a self-expanding cylindrical nitinol mesh. Here we report a case of a 13-year-old boy who had presented with 4 year history of progressive exertional dyspnoea, cyanosis, and clubbing. Pulmonary arterio-venous malformation (multipl...

 Open Access DOI:10.23937/2378-2951/1410191

Syncope in a Patient with H/O Kearns Sayre Syndrome

Saddam Yasin, MD, Kanwal Mehmood, MBBS and Osama Alsara, MD

Article Type: Case Report | First Published: July 29, 2020

Patients with history of mitochondrial disorders are at increased risk of having conduction disorders and cardiomyopathy and should have low threshold for pacemaker and implantable cardioverter defibrillator placement. Kearns Sayre syndrome is the result of deletions in mitochondrial DNA which causes bilateral pigmentary retinopathy and conduction abnormalities. Judicious use of implantable cardioverter defibrillator in this subset population with cardiomyopathy or prolonged QT interval is requi...

 Open Access DOI:10.23937/2378-2951/1410190

Impact of the SARS-Cov-2 Virus Pandemic on Children and Adults with Congenital Heart Disease: Its Burden and Risk Factors

John Jairo Araujo, MD

Article Type: Short Review | First Published: July 25, 2020

The novel coronavirus causes severe acute respiratory syndrome 2, and can infect any population. With the currently available information on the behavior of the pandemic, we conclude that the virus has come to stay. It is clear that the most aggressive behavior and worst outcome of the infection occurs in already established risk groups, such as those with cardiovascular disease. Those with congenital heart disease make up a special risk group. Due to this group’s high heterogeneity and the pa...

 Open Access DOI:10.23937/2378-2951/1410189

Rapid-Onset Thrombocytopenia Following Tirofiban Administration

Andrew M Smith, MD, Timothy G Petrie, MD and Brian J Page, MD

Article Type: Case Report | First Published: July 24, 2020

A 61-year-old male presented to the emergency department with a two day history of intermittent, burning chest pain which became constant and radiated to the left arm. His past medical history was significant for coronary artery disease with two prior myocardial infarctions, three prior cardiac stenting procedures (in 1999, 2001, and 2006), tobacco use with more than a forty pack year history, hypertension, hyperlipidemia, gastroesophageal reflux, cluster headaches, and an early family history o...

 Open Access DOI:10.23937/2378-2951/1410188

Platelet Aggregation Capacity of Clopidogrel Bisulphate Inhibited by Rabeprazole and Simvastatin in Patients Undergoing Myocardial Infarction in a Tertiary Care System: Drug Interaction Study

Jinesh Bahubali Nagavi and Bannimath Gurupadayya

Article Type: Research Article | First Published: July 22, 2020

Proton pump inhibitors and statins reduce the effectiveness of clopidogrel in inhibiting the platelet aggregation. Clopidogrel, a prodrug adheres to CYP2C19, a hepatic enzyme to convert to its active metabolite in order to provide expected therapeutic action. Statins, mainly simvastatin metabolize through cytochrome P450 3A4, which also metabolizes clopidogrel partially. The combination of clopidogrel and PPI’s are co-administered in patients going through ST segment elevated Myocardial infarc...

 Open Access DOI:10.23937/2378-3656/1410314

Immune-Mediated Necrotizing Myopathy with Anti-SRP Autoantibodies and Typical Clinical Presentation

Desislava Kalinova, Alexander Kopchev, Zlatimir Kolarov and Rasho Rashkov

Article Type: Case Report | First Published: July 27, 2020

Immune-mediated necrotizing myopathy (IMNM) is a relatively new disease, described for the first time in 2004. IMNM is a form of myositis since it is an inflammatory myopathy with strict involvement of the skeletal muscles albeit lymphocytic infiltration is sparse or absent. The clinical picture, pathological features and autoantibodies (Abs) of IMNM differ markedly from those of antisynthetase syndrome and non-specific myositis. Anti-HMGCR and anti-SRP Abs are strongly specific for IMNM, but th...

 Open Access DOI:10.23937/2474-3682/1510147

Vitamin-K Dependent Protein Deficiency and Pseudoxanthoma Elasticum

Manish Kumar

Article Type: Image Article | First Published: July 25, 2020

27-year-old male referred from Dental clinic, due to asymptomatic incidental abnormal coagulation parameters. Clinical examination showed loose skin folds of axilla, anterior abdominal wall and chest which were suggestive of Pseudoxanthoma Elasticum. Rest systemic examinations WNL. Patient has similar family history. Coagulation profile showed PT-46 seconds, (control 12.50), INR 4.64 seconds, APTT 61.30 seconds (control 23.80), Mixing Studies-PT 13.8 seconds, PTT-29.7 Seconds....

 Open Access DOI:10.23937/2474-3658/1510150

On Distance Respiratory Virus Transmission: Sate of Evidence

Luisetto M, Naseer Almukthar, A Yesvi Rafa, Manmohan Singh Jangdey, Fiazza C, Ferraiuolo A and Latischev Oleg Yu

Article Type: Research Article | First Published: July 31, 2020

Aim of this work is to verify hypotesys of air-borne transmission on distance related some respiratory and other virus and to compare with actual Covid-19 pandemic diffusion. After an analysis of relevant literature involved and submitting an experimental hypotesys a global conclusion is submitted for further research activity. Some peculiarity in Covid-19 diffusion velocity and mortality rate in some high polluted world region contributes to increase the interest in these topics....

 Open Access DOI:10.23937/2377-9004/1410169

Giant Hemorrhagic Ovarian Cyst with Torsion-Rare Case Report

Durga K, MD, Yasodha A and S Yuvarajan

Article Type: Case Report | First Published: July 23, 2020

Giant ovarian tumours are rare nowadays due to early recognition of these tumours in clinical practice. Management of these tumours depends on age of the patient, size of the mass and its histopathology. We are reporting a rare case of torsion of hemorrhagic ovarian cyst presented to us with acute abdomen. 22-year-old, unmarried girl came to our outpatient department with complaints of lower abdominal pain for 3 days. Patient was apparently normal before 3 days after which she developed lower ab...

 Open Access DOI:10.23937/2377-9004/1410168

A Case of a 33-Week Pregnant Woman with COVID-19 and Term Birth

György Léhner, MD, Walter Krugluger, MD, Stephan W Aberle, MD, Lukas Weseslindtner, MD and Beda Hartmann, MD

Article Type: Case Report | First Published: July 17, 2020

In this case report, we present a pregnant woman diagnosed with COVID-19 at 33 weeks gestation and having a vaginal birth at term. The postpartum and neonatal courses were uncomplicated. Anti-SARS-CoV-2-IgG antibodies were detected in the neonate. A vaginal delivery in this case was safe with clinical diagnosis of COVID-19. To date, there are only limited data about the effect of novel coronavirus (SARS-CoV-2) infection on pregnancy, delivery and placental transfer of antibodies. According to re...