Open Access DOI:10.23937/2474-3658/1510195
The COVID-19 Burden or Tryptophan Syndrome: Autoimmunity, Immunoparalysis and Tolerance in a Tumorigenic Environment
Luiz Gonzaga Francisco de Assis Barros D’Elia Zanella and Luciana de Lima Galvão
Article Type: Review Article | First Published: February 27, 2021
SARS-CoV-2, a new virus, which has been causing the catastrophic pandemic in the world in 2020, triggers numerous physiologic changes in humans, with potentially fatal evolution due to COVID-19. COVID-19 can trigger immunoparalysis with deep and silent immunosuppression and a state of tolerance that may elicit opportunities for neoplastic transformation or latent infectious diseases. In addition, all neurologic or psychiatric symptoms have been observed - as clinically present in usual diseases,...
Open Access DOI:10.23937/2474-3658/1510192
Effect of Hydroxychloroquine or Chloroquine and Azithromycin on COVID-19 Patients' Recovery and Mortality: Evidence from a Hospital Based Retrospective Cohort Study Conducted in Burkina Faso
Adama Baguiya, MD, Msc, Armel Poda, MD, Kadari Cissé, MD, Msc, Apoline K Sondo, MD, Boukary Ouedraogo, MD, PhD, Abdoul Risgou Ouedraogo, MD, Alfred B Tiono, MD, PhD, Pierre Kaboré, MD, Brice W Bicaba, MD, Msc, Jacques Zoungrana, MD, Adama Sourabié, MD, Souleymane Fofana, MD, Flavien Kaboré, MD, Adama Sanou, MD and Séni Kouanda, MD, PhD
Article Type: Original Research | First Published: February 15, 2021
Many countries have adopted hydroxychloroquine (HCQ) or chloroquine (CQ) and azithromycin (AZ) for the treatment of COVID-19 patients at the beginning of the pandemic and are still using them. The objective of this study was to measure the efficacy of CQ or HCQ and combined with AZ on patients' survival and recovery in Burkina Faso, West Africa. We conducted a hospital-based retrospective cohort study using routine data from all the hospitals involved in the COVID-19 response in Burkina Faso. Al...
Open Access DOI:10.23937/2469-5858/1510107
The Influence of Cognitive Biases on Healthcare Provider Decision-Making for Patients with Advanced Dementia
Meira Erel, MSc, Esther-Lee Marcus, MD and Freda De Keyser Ganz, PhD
Article Type: Original Article | First Published: February 22, 2021
Decision-making is at the core of clinical practice. According to traditional decision-making theory, the ideal decision maker acts rationally. However, research in cognitive biases demonstrates that decisions are not perfectly rational, and often rely on unconscious processes. This study was conducted to examine cognitive biases of medical teams when making treatment decisions in acute medical conditions for patients with advanced dementia. This was a phenomenological qualitative descriptive st...
Open Access DOI:10.23937/2469-5769/1510073
Neonatal Hyperbilirubinemia in Low-Income African Countries
Adam C Gamber, Ethan M Toth, Hendrik J Vreman and Tina M Slusher
Article Type: Review Article | First Published: February 19, 2021
Neonatal hyperbilirubinemia, also known as jaundice, is a significant cause of neonate death and disability in low- and middle-income countries (LMICs). Lack of adequate healthcare facilities, unreliable diagnostic- and treatment equipment, limited parental knowledge, and inconsistent- or absent treatment protocols all contribute to exceptionally high rates of morbidity and mortality especially in Sub-Saharan Africa. This review summarizes the etiology and treatment of neonatal hyperbilirubinemi...
Open Access DOI:10.23937/2643-4059/1710023
Frequency of Mental Behavioral Disorders in the Emergency Staff during the Care of Patients in the Covid-19 Pandemic
Hernández Gómez Jesús Alejandro, Palomec Antonio Lizbeth, Ruiz Mondragón Alberto and Sánchez Martínez Fátima Alondra
Article Type: Research Article | First Published: February 15, 2021
As the health personnel fight it spread of COVID-19, has acquired information of alterations psychological featured in professionals and technicians of the health that is in contact with patients infected by this virus. Of according to center carried out, the more alterations frequent in a 85% are: Anxiety, depression and Post-traumatic stress. Anxiety is define like of the answers of our mind and body before situations of danger or threat, the it depresses us talk about a group of diseases ment...
Open Access DOI:10.23937/2378-3419/1410145
Effect of Low Frequency Electrical Current on the Biophysical and Molecular Properties of Cancer Cells
Amit Sengupta, Sanjay Gupta, Asmita Sharda, Hemant S and Arvind Ingle
Article Type: Research Article | First Published: February 25, 2021
Different cells and tissues are known to exhibit varied electromagnetic, electrical and molecular properties. During the repair process, cancer cells as well as normal proliferating cells have higher transmembrane potential than healthy cells. Since the dielectric properties are frequency dependent, applying varying frequencies of current can alter the transmembrane ionic flux of any conductive cell. This, in turn, can generate heat via the joule effect. Thus, it might be possible to alter the t...
Open Access DOI:10.23937/2378-2951/1410218
Determinants of Spatial Dispersion of P-Wave, QRS Complex, and QT-Interval on 12-Lead Electrocardiogram in Apparently Healthy Adults
Nelson I Oguanobi, Charles U Odenigbo, Ogonna C Oguejiofor, Uchenna C Okonkwo, Ukamaka M Odenigbo3 and Tobenna Agogbua
Article Type: Original Research | First Published: February 19, 2021
The spatial dispersion of P-wave, QRS complex, and QT interval on 12-lead electrocardiogram are related to the electrical instability in cardiac conducting tissues and elevated parameters are associated with increased risk of cardiovascular morbidity and mortality. We sought to evaluate the dispersion of P-wave, QRS complex, and QT interval in healthy adult Nigerians and assess their relationship to age, gender, anthropometric and some physiologic parameters. A total of 128 subjects were recruit...
Open Access DOI:10.23937/2378-2951/1410217
Utility of Global Longitudinal Strain to Predict Post-Operative Outcomes in Non-Cardiac Surgeries
Chang Joon Park, Liy Si Tan, Pei Huang, Puay Joo Tan, Jason Jia Hao See, MBBS, MRCP
Article Type: Brief Report | First Published: February 13, 2021
Pre-operative echocardiography is performed in select groups of patients for cardiac risk stratification. Many parameters, including Left Ventricular Ejection Fraction (LVEF), are assessed during echocardiography. While many studies have cited association between low LVEF and poor operative outcomes, patients with preserved LVEF might have subtle LV dysfunction that may result in adverse outcome. Studies have described the routine use of global longitudinal strain (GLS) as an alternative measure...
Open Access DOI:10.23937/2469-5696/1410062
Thrombotic Thrombocytopenic Purpura in a Patient with Systemic Lupus Erythematosus
Diana Guavita-Navarro, MD, Jairo Cajamarca-Baron, MD, Jhon Buitrago-Bohorquez, MD, Laura Gallego-Cardona, MD, Diana Guevara, MD, Hector Cubides, MD, Ana Maria Arredondo, MD and Alejandro Escobar, MD
Article Type: Case Report | First Published: February 19, 2021
Thrombotic microangiopathy is a group of syndromes characterized by thrombocytopenia, microangiopathic hemolytic anemia, and acute organ dysfunction secondary to ischemia. It includes a group of diseases such as thrombotic thrombocytopenic purpura. They can be primary or secondary to multiple pathologies, including autoimmune diseases such as systemic lupus erythematosus. These associations are important from the clinical point of view, as they have more severe presentations, high relapse rates,...