Open Access DOI:10.23937/2643-4571/1710039
Peripheral T-Cell Lymphomas in Algeria: Results from a Multicenter Registry Study
Nadia Boudjera Belarbi, Mohamed Amine Bekadja, Mohanad Tayeb Abad, David Webb and Fatiha Grifi
Article Type: Case Series | First Published: March 24, 2022
Peripheral T-cell lymphomas (PTCLs) are a rare and heterogeneous group of aggressive malignancies derived from mature (postthymic) T lymphocytes. Currently, there are no published data describing the clinical characteristics and outcomes of Algerian patients with PTCL. To describe the clinical characteristics and treatment outcomes of patients included in an Algerian PTCL registry. Multicenter, non-interventional, cohort registry study of all patients with a diagnosis of PTCL attending four spec...
Open Access DOI:10.23937/2469-5769/1510093
Pediatric Abusive Head Trauma: A Case Series in a Tertiary Hospital
Andreia Marinhas, Ana Isabel Martins, Anabela Fazendeiro, Patrícia Lourenço, Filomena Freitas, Marta Machado and Beatriz Maia Vale
Article Type: Case Series | First Published: March 30, 2022
Characterise cases of Abusive Head Trauma (AHT) over an 8-year period in a tertiary hospital in Portugal, including the main demographic and clinical characteristics, as well as long-term follow-up and sequelae. Retrospective review of all cases of AHT admitted between 1st of January 2013 and 31st of December 2020 in a Portuguese pediatric tertiary hospital. We characterize all cases descriptively, about demographic, clinical and social characteristics. Between 2013 and 2020, 7 cases of abusive ...
Open Access DOI:10.23937/2469-5769/1510092
Transition from Pediatric to Adult Care of Pediatric Patients with Chronic Disease: Experiences and Perspectives of Pediatricians and Internists at a Private Tertiary Hospital in the Philippines
Maria Anna F Perez, MD, Rosa Maria Nancho, MD, FPPS, FPSAMS, FiFePAG and Rhea Salonga-Quimpo, MD, FPPS, FCNSP, FPNA
Article Type: Original Article | First Published: March 30, 2022
The improving survival rates and life expectancy of patients with pediatric-onset chronic diseases led to a rise in the number of individuals requiring transition to adult care. A successful Health Care Transition (HCT) is vital in ensuring therapy adherence, continuity of care, and positive health outcomes. Both pediatricians and internists are key stakeholders in the transition process and have equally valuable input in improving HCT policies and programs. Pediatricians and internists in activ...
Open Access DOI:10.23937/2469-5807/1510125
Criteria for Presumptive Diagnosis of IgD Multiple Myeloma
Gurmukh Singh, MD, PhD, MBA
Article Type: Research Article | First Published: March 25, 2022
IgD myelomas constitute about 1% of myelomas, have worse prognosis, have higher association with lambda light chains, and are associated with excess free involved light chains. Standard immunofixation protocols stain only for IgG, IgM and IgA heavy chains. Proper attribution of a monoclonal gammopathy as having a delta heavy chain requires additional testing that is not available in most clinical laboratories. Retrospective review of protein electrophoresis and other laboratory results showed ch...
Open Access DOI:10.23937/2643-4539/1710022
Cognitive Decline in Parkinson's Disease: Theories and Implications for Rehabilitation
Katherine A Brown, PhD, CCC-SLP, CBIS, Dale KL Summers, MS, CCC-SLP and Kristie A Spencer, PhD, CCC-SLP
Article Type: Review Article | First Published: March 30, 2022
Cognitive changes in Parkinson’s disease (PD) can occur at any stage of the disease and have been shown to significantly impact well-being and life participation. The nature and pattern of cognitive decline in PD remains unclear due to the heterogeneity of symptoms and lack of a clear explanatory model. This review aims to draw attention to several theoretical models of cognitive decline in PD to deepen our understanding of the complex milieu of symptoms and begin to offer clinical implication...
Open Access DOI:10.23937/2377-3634/1410155
Effective Treatment of Diabetes Mellitus by Resonance Medicine
Praznikov Victor
Article Type: Literature Review | First Published: March 31, 2022
The first type of diabetes is insulin dependent. As a rule, in such patients, more often children or adolescents, the full range of consequences of reduced immunity is revealed. At the same time, cholecystitis is diagnosed, possibly gallstones, pyelonephritis, and kidney stones. As a rule, chlamydia, a large number of viruses, fungi, helminths are detected. All this is entered into the prescription for the preparation of the drug for treatment. Beta-cells of the pancreas in some patients with th...
Open Access DOI:10.23937/2378-3656/1410388
A Double-Edged Sword - Multiorgan Dysfunction as a Rare Complication of Dual Checkpoint Immunotherapy
Matthew Boykow, Ami K Patel1, Neil Sondhi, Eli Wercberger, Asif Mohammed, Devarajan Iyengar, Antonios Tsompanidis and John Dedousis
Article Type: Case Report | First Published: March 31, 2022
There are many immune checkpoints in the body which serve different functions. Some Immune checkpoints are molecules involved in the maintenance of immunologic homeostasis, and therefore help to maintain peripheral tolerance to self-molecules. Other immune checkpoints such as CTLA-4 and PD- 1, are important for augmenting or inhibiting the immune response. Yervoy (Ipilimumab) and Opdivo (Nivolumab) are monoclonal antibodies developed to target CTLA-4 and PD-1 respectively to augment the immune s...