Open Access DOI:10.23937/2378-2951/1410271
siRNA-Induced Silencing of LP(a) Gene: An Ideal Choice to Prevent Genetic Risk of Myocardial Infarction
Muhammad Arslan
Article Type: Review Article | First Published: November 18, 2022
Elevated level of lipoprotein (a) gene is the main cause of inherited risk of myocardial infarction (MI). Several RNA based therapies are being developed to reduce the expression of LP(a) gene, but none of them are neither available in market, nor have been declared as perfect choice for treatment. An American multinational biopharmaceutical company, Amgen Inc, has recently disclosed remarkable test results of phase II trial of Olpasiran [a small interfering RNA-based (siRNA) therapy to target L...
Open Access DOI:10.23937/2643-3966/1710053
Persistence of Stress Related Left Ventricular Filling Abnormality in Treated Hypertensive Patients
Gaston K Kapuku, Michelle L Brown, Shin Suzuki and Steven Coughlin
Article Type: Original Article | First Published: November 20, 2022
Hypertension is associated with impaired left ventricular (LV) diastolic function. However, the impact of stress on LV filling of treated hypertensive individuals is unclear. Fourteen hypertensive patients (mean age 55 years) and 14 age-sex matched normotensive controls underwent Doppler echocardiographic studies at rest and one minute following supine ergometer bicycle. The evaluations were done before and under treatment with diltiazem (180 mg/ day) during 24 weeks. Resting blood pressure cont...
Open Access DOI:10.23937/2378-3656/1410411
ADM-Assisted Implant Based Breast Reconstruction vs. Free Tissue Transfer Breast Reconstruction
Mohammad Mohammad
Article Type: Original Article | First Published: November 22, 2022
Despite in the recent decade, the free tissue transfer has been the gold standard for breast reconstruction and evolving of DIEP, TUG flaps toe the most common used breast reconstruction approach at present time, however the complexity of the procedure, long operative time, donor site comorbidities, long learning curve and subsequently increased cost were always present as downside of this approach...
Open Access DOI:10.23937/2572-4061.1510049
Health and Environmental Risk Assessment of Toxic Metals and Metalloids Burdened Soil Due to Anthropogenic Influence
Omobolaji O Afolabi, Elekwachi Wali, Eze C Ihunda, Sunny O Asomaku, Olushola IT Yemi- Jonathan, Nnamdi C Ogbuehi, Lilian C Bosco-Abiahu, Maureen C Orji and Victoria O Emelu
Article Type: Research Article | First Published: October 10, 2022
Landfill area is one of developing countries’ most common anthropogenically contaminated sites. The pressure of urbanization has led to increased waste generation in major cities, commonly deposited in landfills; hence, heavy metals contaminations are closer to the human environment than ever. The study assessed the environmental risk of Arsenic (As), Cadmium (Cd), Zinc (Zn), Manganese (Mn), Copper (Cu), Colbat (Co), Cranium (Cr), Nickel (Ni), and Lead (Pb) in an abandoned landfill system and ...
Open Access DOI:10.23937/2643-4474/1710126
FAHR's Disease and MCA Aneurysm Bleeding Case Report
Aykut İLİKHAN, Şükrü ORAL, Mehmet Berat ERTURHAN and Masud YUSİFOV
Article Type: Case Report | First Published: November 09, 2022
Fahr's disease is named after the German neurologist Karl Theodor Fahr, who first reported it in 1930. This is a rare neurological condition characterized by abnormal idiopathic calcification of the basal ganglia and is usually inherited in autosomal dominant manner. These calcifications are consisted of calcium carbonate and phosphate, and may also occur in some other locations, such as thalamus, hippocampus, dentate nucleus, cerebral cortex, and cerebellar subcortical white matter....
Open Access DOI:10.23937/2469-5696/1410084
Iliopsoas Hematoma as Unusually Early Onset of Hemophilia A in a Young Infant
Coppo D, Rossi L, Raffaldi I, Aguzzi S, Castagno E, Ricca I and Bondone C
Article Type: Case Report | First Published: November 14, 2022
A 2-month-old infant was admitted for irritability and hypomobility of the left lower limb. Ultrasound revealed a deep hematoma of the iliopsoas muscle and coagulation tests showed increased activated partial thromboplastin time (aPTT). The finding of marked reduction of blood coagulation factor VIII (FVIII) led to the diagnosis of severe Hemophilia A. The infants were promptly put on i.v. factor VIII concentrates, resulting in rapid clinical improvement....
Open Access DOI:10.23937/2378-346X/1410143
Raised Intracranial Pressure in an Obese Female Due to VZV Meningitis
Hassan Lami, MD, Sebastian Brown and Clare Fraser
Article Type: Case Report | First Published: November 11, 2022
Initial infection with VZV causes varicella (or ‘chickenpox’). This is a primary infection which can then lie dormant in sensory ganglion cells; when reactivated it is termed herpes zoster [1]. Common reported neurological complications of primary varicella infection are meningoencephalitis and acute cerebellar ataxia [2]....
Open Access DOI:10.23937/2643-3885/1710073
Synovial Chondromatosis with Concerning Features on Histopathology
Ramanathan RM Palaniappan and Michael Hunter
Article Type: Case Report | First Published: November 11, 2022
Synovial chondromatosis (SC) is a rare benign condition which involves synovial metaplasia and proliferation resulting in formation of multiple cartilaginous nodules in the synovium of the joints. It most commonly involves large joints such as hips and knee and is less frequently present in smaller joints. While it is a benign condition, primary synovial chondromatosis (PSC) can undergo malignant transformation into synovial chondrosarcoma. Their clinical and radiological features are very simil...