Open Access DOI:10.23937/2474-3674/1510150
Factors Affecting Mortality in Patients with Acute Pancreatitis and Serum Calcipressin-1 (RCAN-1) Levels
Emrah Savaş, Mustafa Burak Sayhan, Ömer Salt and İlker Dibirdik
Article Type: Original Article | First Published: November 30, 2022
Acute pancreatitis (AP) is one of the most common diseases of the gastrointestinal tract. AP is a pancreatic disease with high mortality and morbidity, which can cause local and systemic complications This study aimed to determine factors that effect mortality in this patient group and whether serum RCAN-1 level can be used as a novel marker for predicting diagnosis and mortality in patients with AP and to investigate the factors affecting mortality in this patient group....
Open Access DOI:10.23937/2378-2951/1410272
Effect of Edoxaban, F-Xa-Directed Oral Anticoagulant on Spontaneous Thrombolytic Activity in Apoe-/- and Ldlr-/- Double Knockout Mice
Kanae Hyodo, MS, Naotaka Ohta, PhD, Hiromitsu Ishii, MD and Tsutomu Yamashita, PhD*
Article Type: Original Article | First Published: December 01, 2022
The details of thrombolytic activity in occlusive disease associated with atherosclerotic lesions are not clear. This study investigated the novel effects of activated coagulation factor X (F-Xa)-directed oral anticoagulant (DOAC) edoxaban on in vivo thrombolytic activity and atherosclerosis progression. Mice were fed an experimental diet (edoxaban 15-50 mg/kg) for 18 weeks. The degree of progression of atherosclerosis was assessed as the area of atherosclerotic vessels as a percentage of the to...
Open Access DOI:10.23937/2469-5696/1410087
Geographical Variation of Acute Promyelocytic Leukemia: A Single Center Study from Saudi Arabia
Assem Elghazaly
Article Type: Brief Report | First Published: December 11, 2022
There is no obvious underlying cause for de novo acute promyelocytic leukemia (APL). Recently two case studies showed that the virus torque teno mini (TTMV) has a role in the pathogenesis of APL/APL-like disease. Few studies reported seasonal or geographical clustering of the disease. As no local published research addressed the effect of these two factors on the incidence of the disease, we aimed to study the relationship between geographical and seasonal factors and the incidence of APL in the...
Open Access DOI:10.23937/2469-5696/1410086
A Prospective, Observational Study to Assess Effect of DTT Treatment on ABO Isoagglutinin Titers in O Blood Group Donors
Shweta Ranjan, MBBS, Prashant Pandey, MD, Divya Setya, DNB and Supriya Kumari, MBBS
Article Type: Original Article | First Published: December 08, 2022
To determine actual concentration of clinically significant IgG antibodies, there is need to inactivate IgM antibodies. Aim of this study was to study effect of dithiothreitol (DTT) on ABO isoagglutinin titers performed by column agglutination technology (CAT) and conventional tube technique (CTT) and to compare results obtained by DTT treatment. This was a prospective, observational study conducted from October 2018 to March 2020. All consecutive O group donors were included. All samples were c...
Open Access DOI:10.23937/2690-263X/1710015
Ethyl Glucuronide as a Sensitive Marker of Alcohol Abuse
Razvodovsky YE
Article Type: Original Article | First Published: December 10, 2022
An important strategy for the prevention of alcohol-related problems is the early diagnosis of alcohol abuse. The present paper aims at a systematic review of the current knowledge on ethylglucuronide (EG) in blood as a direct marker of alcohol abuse. The research evidence suggests that EG in the urine is a promising marker of episodic alcohol consumption in large doses, while EG in the hair is a reliable indicator of chronic alcohol abuse....
Open Access DOI:10.23937/2469-5823/1510179
Futility in Cardiopulmonary Resuscitation of Pre-Hospital Emergency
Mojtaba Senmar and Mohaddese Aliakbari
Article Type: Letter to Editor | First Published: December 11, 2022
Out-of-hospital cardiac arrest (OHCA) is cardiac arrest that occurs outside of a hospital setting. Cardiopulmonary resuscitation (CPR) is the foundation of treatment for this major global health problem with high mortality, that improving patient’ chances of survival. The results of a meta-analysis study on OHCA showed that the rate of survival to hospital admission, the rate of survival to hospital discharge, the pooled 1-month survival rate and the 1-year survival rate are 22.0%, 8.8%, 10.7%...
Open Access DOI:10.23937/2572-407X.1510032
Accuracy of Flash Glucose Monitoring in Critically Ill Patients Receiving Intravenous Insulin
Jia Wei Tan, MD, Sachin K Majumdar, MD
Article Type: Brief Report | First Published: December 11, 2022
To compare the Free Style Libre (FSL) 2 14- day Flash Glucose Monitoring (FGM) and Point-Of-Care Capillary (POC) Blood Glucose (BG) testing among critically ill patients who receive insulin infusion. We conducted an open-label, prospective study and enrolled stepdown or critical care unit patients on intravenous insulin. Paired POC and GCM values were obtained to calculate the Mean Absolute Relative Difference (MARD). Accuracy was further evaluated with error grid analysis between matched glucos...