Long-term Maintenance HP Acthar® Therapy for the Treatment of Refractory Idiopathic Membranous Nephropathy
Anushka Chadha, MD and Inderpal Chadha, MD
Article Type: Case Report | First Published: June 11, 2020
Current first-line treatments for idiopathic membranous nephropathy often insufficiently reduce proteinuria and creatinine. Additional treatments options are needed for these refractory cases. Herein, we describe the case of a 68-yearold white male with worsening dyspnea and peripheral lower extremity edema with biopsy-proven membranous nephropathy, without any identifiable secondary causes of the disease. He failed to achieve partial or complete remission after initial therapy of enalapril, ato...
Isolated Renal Mucormycosis in an Immunocompetent Individual
Amit Katyal, Preet Shah and PM Dogra
Article Type: Case Report | First Published: April 16, 2020
Isolated renal mucormycosis is rarely reported in immunocompetent individuals. It carries a grave prognosis and the diagnosis is often achieved post-mortem. We report the case of a 22-year-old immunocompetent gentleman who presented with fever, abdominal pain and renal failure. He was managed with antibiotics, Amphotericin-B and underwent nephrectomy, with a favourable outcome. The case emphasizes that isolated renal mucormycosis may affect immunocompetent individuals. The aggressive nature of d...
Renal Equations Using Cystatin C and Creatinine in Correlation to Lipids in Chronic Kidney Disease - A Cross-Sectional Study
P Ravi Kumar, MD, Mitali Srivastava, MD and S Asmathulla, MD
Article Type: Original Research | First Published: April 15, 2020
This cross-sectional study, comprising of 120 CKD patients, attempted to determine, which of the two equations for estimating GFR, either by serum cystatin-C or by serum creatinine, is better related with lipid profile which is widely portrayed as a cardiovascular risk factor. The parameters evaluated included lipid profile, serum creatinine and serum cystatin-C among others. Staging was done by both the equations (MDRD equation by creatinine and CKD-EPI equation by cystatin-C) and compared, and...
Two Rare Mechanisms for Acute Anuric Renal Failure in a Patient with Metastatic Malignant Melanoma - A Case Report
Amy D Kennedy, MD, Alex J Liu, MD, Regan M Seipp, MD, Margaret S Ryan, MD, Shaun K Yang, MD, MPH and Leslie F Thomas, MD
Article Type: Case Report | First Published: September 27, 2019
This case report examines two rare mechanisms of acute renal failure in a patient with metastatic melanoma treated with high-dose vitamin C. The first is oxalate nephropathy, which is an uncommon but known complication of highdose vitamin C therapy in naturopathic medicine. The second is due to melanuria and renal melanosis, which has been described in metastatic melanoma; however, acute renal failure requiring renal replacement therapy has not been reported previously. We report a patient with ...
Prevalence, Etiology and Clinical Characteristics of Biopsy Proven Non-Diabetic Renal Disease in a Population of 67 Diabetic Patients
Joana Monteiro Dias, Rita Valerio Alves, Mario Gois, Helena Viana and Fernando Nolasco
Article Type: Original Article | First Published: September 25, 2019
Diabetic nephropathy (DN) has been historically the major cause of kidney disease in diabetic patients. However, recent studies have found a high proportion of diabetic patients with biopsy proven Non-diabetic renal disease (NDRD) or NDRD superimposed on DN. These findings have resurfaced the interest in establishing which of these patients may benefit most from a kidney biopsy. Our study aims to enlighten the prevalence and etiology of biopsy proven NDRD and to explore clinical and morphologic ...
Quality of Life in Chronic Hemodialysed Patients: Observational Study in Three Hemodialysis Units in Semi-Urban Areas of Senegal (West Africa)
Kane Yaya, Biao Hermann B, Faye Moustapha, Hamat Ibrahim, Lemrabott A Tall, Faye Maria, Sakho Diama, Camara Mame Selly, Cisse M Moustapha, Seck S Mohamed, Ka El Fary, Niang Abdou and Diouf Boucar
Article Type: Research Article | First Published: August 26, 2019
End-stage renal failure has a significant impact on patients’ daily lives, which can be measured by quality of life questionnaires. The objective of this study was to assess the health condition related to quality of life in hemodialysed patients in three semi-urban hospitals of Senegal and to determine the factors associated with it. During an observational, transversal, descriptive and analytical study conducted for 2 months, between March 1st and April 30th, 2016, the patients’ records, i...
Optimizing Control of Anemia with Ferric Carboxymaltose Administration in Peritoneal Dialysis
JL Merino, MD, PhD, E Garcia, NP, S Castrillo, NP, S Mendoza, NP, V Sanchez, NP, B Bueno, MD, P Dominguez, MD, B Espejo, MD and V Paraiso MD
Article Type: Original Article | First Published: July 12, 2019
Administration of single dose of ferric carboxymaltose (FCM) is useful for both control of anemia in hemodialysis patients and end stage renal disease. Its use in peritoneal dialysis (PD) patients is not as well known. We report our experience of FCM administration in PD patients. PD patients treated with i.v. in the last three years in our unit were analyzed retrospectively. Main reasons for administration of i.v. iron therapy were evaluated. Previously oral iron therapy or erythropoietic stimu...
Autophagy and Transforming Growth Factor Beta1 in Renal Tubular Epithelia Cells
Rui Hong Chen, Fen Song, Yu Gan, Ting Ting Li, Lin Ye, Wei Jing Liu and Hua-Feng Liu
Article Type: Review Article | First Published: May 29, 2019
Transforming growth factor beta1 (TGF-β1) is regarded as the important factor in many fibrotic kidney diseases. Autophagy is a vital mechanism which maintains intracellular homeostasis in eukaryotic cells and involves in various renal physiologic and pathological processes. Current studies indicate that autophagy in renal tubular epithelial cells serves as a renoprotective mechanism which modulates the course of diverse kidney disease....
Hyper-Acute Presentation of Access Based Cardiac Disease
Mohamed A Sheta, MD, Axita Patel, OMS and John R Ross, MD
Article Type: CASE REPORT | First Published: February 23, 2019
Fifty years after the creation of the first arteriovenous access, little is known about the deleterious cardiac effects of this pathological circuit. Understanding the pathophysiology of Access Based Cardiac Disease (ABCD) is critical, given the fact that cardiac abnormalities are the leading cause of morbidity and mortality in end stage kidney disease patients on dialysis. However, this has been a challenge, as many of hemodialysis patients have preexisting cardiac disease, they invariably have...