Khandpur U, Ray WZ, MacEwan MR (2019) Clinical Performance of a Novel Fully Synthetic Dura Substitute. Neurosurg Cases Rev 2:018.


© 2019 Khandpur U, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

CASE SERIES | OPEN ACCESS DOI: 10.23937/2643-4474/1710018

Clinical Performance of a Novel Fully Synthetic Dura Substitute

Umang Khandpur*, BS, Wilson Z Ray, MD and Matthew R MacEwan, PhD

Department of Neurosurgery, Washington University School of Medicine, USA



Despite the range of available dura substitutes, limitations such as harvest site morbidity and graft degradation still exist. As such, there is a need for an optimized dura substitute with superior safety and mechanical properties than currently available products.


A retrospective case series was performed to evaluate the efficacy of a novel, fully synthetic dura substitute. Clinical outcomes (e.g. infectious, reoperation rates, cerebrospinal fluid leak) and surgeon experiences with the dura substitute intraoperatively were collected. All methods were approved by the Institutional Review Board at Washington University School of Medicine.


This study explored the clinical performance of a fully synthetic nanofabricated dura substitute. Case analysis demonstrated none required reoperation or had clinical evidence of CSF leakage, pseudomeningocele, or meningeal disease after surgery. Results from the physician survey indicated that this dura substitute offered benefits in tensile strength appropriate for a variety of neurosurgical procedures.