Despite the range of available dura substitutes, limitations such as harvest site morbidity and graft degradation still exist. As such, there is a need for an optimized dura substitute with superior safety and mechanical properties than currently available products.
A retrospective case series was performed to evaluate the efficacy of a novel, fully synthetic dura substitute. Clinical outcomes (e.g. infectious, reoperation rates, cerebrospinal fluid leak) and surgeon experiences with the dura substitute intraoperatively were collected. All methods were approved by the Institutional Review Board at Washington University School of Medicine.
This study explored the clinical performance of a fully synthetic nanofabricated dura substitute. Case analysis demonstrated none required reoperation or had clinical evidence of CSF leakage, pseudomeningocele, or meningeal disease after surgery. Results from the physician survey indicated that this dura substitute offered benefits in tensile strength appropriate for a variety of neurosurgical procedures.