Blacks have a greater need for kidney transplants than other American ethnic groups. Overrepresented on kidney transplant waiting lists (13%), they account for 35% of those waiting. Recent studies show that Black live donors are at greater risk for kidney failure, (44%) after donation, compared to other ethnicities. Explanations for these live donation data are few. While diabetic, hypertensive or morbidly obese Blacks are excluded as live donors; those overweight or obese are not.
To examine relationships between BMI, waist circumference [WC] and GFR as potential risk factors for CKD in relatively healthy Blacks.
Participants included 214 Black community volunteers from the Washington, DC area. Physical exams, laboratory and anthropometric data were collected. Creatinine clearance (Cr Cl) was calculated using the Cockcroft-Gault equation method.
Sample mean age was 45 years; 48% were males. Mean BMI and waist circumference were 31 and 38 respectively. Bivariate correlation analyses showed BMI and waist circumference correlated with GFR > 130 cc/min. (r = 0.67, p < 0.01 and r = 0.66, p < 0.01, respectively). Logistic regression analyses revealed that BMI and WC classified obese males were more likely to have a GFR > 130. BMI-categorized obese women were more likely to have a GFR > 130.
Results indicate that increased BMI (> 30 kg/m2), increased waist circumference (> 40 inches) and increased GFR (> 130 ml/min) were strongly correlated in Black volunteers. Black donors with obesity risk factors, when combined with GFR > 130 may be the factors placing overweight or obese AAs at increased risk for CKD after kidney donation.