Medical treatment which is focused on symptoms and reducing inflammation is the first step for the management of inflammatory bowel diseases . Despite optimal medical therapy, up to 30% of the patients with ulcerative colitis will require surgery during their lifetime . Colectomy and removal of rectum provide complete cure from the disease. But post-operative complications are major point of concern because most of the patients are worn out by extended medical therapy, malnutrition and hemorrhage [3,4]. Thereby, they are prone to post-operative morbidity and surgery decision is a delicate matter. This decision is best taken by an integrated, multidisciplinary approach between surgeon, gastroenterologist and patient. Patient status (e.g., nutritional status, previous treatment) and timing of surgery (e.g., urgent, elective) are the most important factors affecting surgical technique. The procedures may be divided into two categories based on timing; elective surgery and urgent surgery.
Reasons for elective surgery mostly rely on discontinuity of the medical therapy. Other reasons are dysplasia and cancer . An elective surgery must be directed on removal of colon and rectum thus eliminating the target organ while achieving low mortality and morbidity rates and high quality of life. But with surgery comes complications, therefore different surgical techniques have been proposed to find better early and late outcomes and surgery for ulcerative colitis has evolved over the years (Table 1).
Table 1: Indications for elective surgery. View Table 1
In both elective and emergency setting, till the late 1950's, total proctocolectomy and ileostomy was the only procedure for ulcerative colitis patients . But it is still a valid surgical option for selected patients who doesn't want pouch surgery and who are at risk for pouch failure such as elderly patients, patients with impaired sphincter function, additional comorbidities or history of anal surgery. Despite it is a one-stage procedure, it requires pelvic dissection and leaves patients with ostomy to live. Therefore complications are mostly stoma related like skin lesions, parastomal hernia, retraction and prolapse. Other complications are common to any procedure that includes pelvic dissection. Obstruction, infertility, sexual and bladder dysfunction and infection are of those. Reduced quality of life and functionality due to ostomy are considered pitfalls of this technique.
In 1980, Alan Parks and his friends described ileal pouch anal anastomosis (IPAA) and ever since most common approach for elective surgery has been restorative proctocolectomy with ileal pouch anal anastomosis . Different pouch designs (e.g., S, J, W and H) were proposed but J pouch has been accepted widely because of functional results and quick construction . Total proctocolectomy and IPAA can be performed in one, two and three stages depending on surgeon and patient condition . One-stage procedure is mostly reserved for stable patients. For instance, patients who are young, healthy and those on no drugs are candidates for non-diverted surgery . A two stage procedure which is the most common choice is composed of colectomy, pouch construction and loop ileostomy which is planned to be closed at a later time. A three stage procedure is composed of colectomy and ileostomy in the first stage, pouch construction in the second stage and ileostomy closure in the last stage. Multi-stage procedures are well suited for patients with poor nutritional status, acute colitis and those on high-dose steroid as they provide time for mucosal healing and detachment from immunosuppressives and steroids.
For IPAA, mortality rates have dropped below 1% in expert centers in the last decade and overall morbidity rates vary from 19% to 27% according to the literature . Complications due to IPAA can be divided into two groups as short-term and long-term (Table 2). In an analysis of 3717 patients from Cleveland Clinic, short-term complications were observed in 33% of patients and long-term complications in 29% .
Table 2: Complications following total proctocolectomy with ileal pouch anal anastomosis. View Table 2
The most important complication after IPAA is pelvic abscess which is a result of either anastomotic failure or infrequently, infected hematoma. Post-operative fever should arouse suspicion and urgent measures must be taken to reveal underlying reason. Because, pelvic sepsis may result in pouch failure, fistula and anastomotic stricture. Pouchogram with water-soluble contrast or pouchoscopy can be helpful to check integrity of the anastomosis . If double stapled techniques are used, also the vagina must be examined for fistula. According to the size and extent of the pelvic abscess, there are different treatment approaches from broad-spectrum antibiotics to surgical intervention. For small abscess, antibiotics can be appropriate. For larger abscess, transanal drainage, drainage under radiological guidance are non-surgical measures but these methods may fail to control pelvic sepsis and eventually surgery is required . For anastomotic leaks, diverting ileostomy is formed if not previously done. If total disruption of anastomosis is present, one should prefer externalizing the pouch.
The most common late-complication of IPAA is Pouchitis which presents itself as pelvic pain, cramps, fever and increased number of defecation. But there is lack of consensus regarding the definition of Pouchitis in the literature and because of that reported rates of pouchitis whether early or late, differ from each other. For instance, in the study of Cleveland Clinic, Pouchitis rate following IPAA was 33%. It was 48% at 10 years in the report of Mayo Clinic . These values are high when compared to other reports [15,16]. Antibiotics mostly ciprofloxacin and metronidazole are the primary treatment and endoscopic biopsy is required sometimes for confirmation . In rare cases of severe Pouchitis, ileostomy with or without pouch excision is required.
Sexual dysfunction and infertility are other concerns following pouch surgery. This is a result of pelvic dissection which is required for rectal resection. Although results of the published reports are controversial, mostly women are at risk and overall infertility rates vary from 38% to 64% [18,19]. Before the operation, patients should be enlightened as to the possible negative effects on fertility.
In a systematic review it was stated that quality of life following IPAA improves a year later and UC patients become undistinguishable from the healthy ones irrespective of morbidity .
During the 1960's, subtotal colectomy with ileorectal anastomosis was proposed as an alternative method to total proctocolectomy and ileostomy. While lack of pelvic dissection and ileostomy construction are advantages of this technique theoretic risk of cancer arousing from the remnant rectal mucosa is a disadvantage. It requires follow up of the rectal mucosa for malignant change. Presence of rectal inflammation and loss of rectal compliance are contraindications to this technique. It is a surgical alternative in female fertile patients as it has no negative effect on fecundity .
Main goal of the urgent surgery is retaining good health of the patient as soon as possible in order to perform future restorative procedures  (Table 3). Emergency surgery carries a great deal of mortality and morbidity when compared to elective surgery. In an analysis of ulcerative colitis patients that underwent emergency surgery, despite late medical advances, 30-day mortality rates were reported 13% . In large series from Europe, following urgent surgery 30-day mortality rates vary from 2.4% to 5.2% [24,25]. Higher rates should be expected in cases with advanced age, malnutrition and previous history of high dose immunosuppressive.
Table 3: Indications for emergency surgery. View Table 3
Subtotal colectomy with ileostomy and Hartmann's procedure is a safe and fast technique under emergency conditions. Distal stump may be either left in pelvis, created as a mucous fistula or placed superfascially. Also insertion of rectal drainage tube may decrease postoperative pelvic sepsis after this procedure . After superfascial placement of distal colonic stump or creation of mucous fistula, fewer pelvic complications and less morbidity rates were reported . But also there are reports that states intraperitoneal Hartmann's closure can be performed safely in selected patients.
Total colectomy is also an option but it requires pelvic dissection and high rates of hemorrhage, nerve damage and pelvic sepsis were reported. Regarding total proctocolectomy and IPAA, Heyvaert, et al. reported very high morbidity and anastomotic leak rate when compared to elective surgery and they specified it as a contraindication to emergency surgery .
Minimally invasive surgery is the followed trend in the last decade. One of the first type laparoscopic surgeries is being used since 1992 for ulcerative colitis surgery . With the technological development and growing experience, single instrument laparoscopic surgery and natural orifice transluminal endoscopic surgery have followed this trend . Nowadays there are published reports using robotic systems for total proctocolectomy and IPAA. But they are mostly case reports and not enough to compare short-term and long-term outcomes [31,32].
Laparoscopic procedures minimize the surgical trauma to these patients. Thus they cause less pain and also improve cosmesis and relatively patient satisfaction. Despite demanding and time consuming, they provide patients with rapid recovery, comfort and reduced burden of adhesion related problems according to the literature . There are reports comparing laparoscopy in both urgent and elective surgery. Yet, they are not sufficient to suggest it as a standard approach . When technical expertise and facility are available, laparoscopy seems a better approach in elective setting.
Total proctocolectomy and IPAA is now considered the standard treatment of ulcerative colitis requiring surgery according to latest guidelines but there are still controversies regarding IPAA can be performed safely in the elderly. Either elective or urgent, operative mortality rates have been found higher in older patients . Age itself isn't a contraindication for IPAA but with advanced age comes comorbidities, muscular atrophy and sclerosis thereby anal sphincteric muscles weaken. Thus, careful planning must be put before the surgery. Total proctocolectomy and end-ileostomy is a better approach in elderly as it provides eradication of target organ and discharge of intestinal content easily when construction of pouch is contraindicated or not technically possible. Subtotal colectomy and ileorectal anastomosis is another alternative in those patients. It is a quick operation with less dissection and avoiding stoma is an advantage. It also provides quick return to social life [36,37].
In the original operation of IPAA, Parks denuded rectal mucosa to prevent recurrence and performed a hand-sewn anal anastomosis. Since the introduction of stapled techniques, there has been an ongoing debate over which technique is better. According to the large series comparing hand-sewn and double-stapled techniques, there wasn't significant difference regarding functional results and recurrence. In the recent studies, quality of life and functional outcomes after stapled-IPAA were significantly higher than hand-sewn-IPAA . In the report of Kirat and Remzi, they compared both techniques in 3.109 patients and stated that patients undergoing stapled techniques had less complications and better quality of life .
None to declare.
None to declare.