Gingival ulcer is often accompanied by severe pain and bleeding and prevents the practicing of appropriate oral hygiene. Most inflammatory and immune-mediated gingival ulcers can be successfully treated with topical corticosteroids, but those refractory to corticosteroids are difficult to treat.
An 18-year-old female visited our clinic with a complaint of gingival bleeding. Since topical corticosteroids and oral antibiotic were not effective for gingival ulcers of the patient, an anti-gastric ulcer agent, irsogladine maleate, was used. Oral administration of irsogladine maleate reduced gingival bleeding. The patient became able to perform tooth brushing, and the bleeding from the gingivae was markedly improved.
Oral administration of irsogladine maleate may be useful to improve persistent bleeding from gingival ulcers caused by inflammatory and immune-mediated gingival disease with minimal adverse effects.