Central giant cell granuloma (CGCG) is an uncommon benign bone lesion that occurs in the mandible and maxilla and accounts for approximately 7% of all benign tumors of the jaws. The clinical behavior of CGCG is classified as aggressive or non-aggressive based on clinical and radiographic features. CGCG usually occur in patients less than 30 years of age. The radiological findings are diverse, ranging from small unilocular to large multilocular lesions. Treatment can be non-surgical (alpha interferon, calcitonin and corticosteroids) or surgical (curettage, enucleation and en bloc resection). This paper reports a case of a 27-year-old male patient with a diagnosis of CGCG in left mandible that was treated with marginal resection.