Shinonaga Y, Arita K, Imataki R, Takemura M, Nagaishi C, et al. (2018) Novel Multi-Functional Dental Cement for Enamel Remineralization and Anti-Cariogenic Bacteria Activity. Int J Oral Dent Health 4:065.


© 2018 Shinonaga Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

RESEARCH ARTICLE | OPEN ACCESSDOI: 10.23937/2469-5734/1510065

Novel Multi-Functional Dental Cement for Enamel Remineralization and Anti-Cariogenic Bacteria Activity

Yukari Shinonaga1*, Kenji Arita1, Rie Imataki2, Michiko Takemura2, Chikoto Nagaishi2, Keiichi Kagami2, Takako Nishimura1, Yoko Abe1, Sho Aoki2, Masae Okuno2 and Kyoko Harada1

1Department of Pediatric Dentistry, School of Dentistry, Osaka Dental University, Japan

2Graduate School of Dentistry (Department of Pediatric Dentistry), Osaka Dental University, Japan



This experimental study evaluated the release of fluoride and several minerals related to remineralization from a novel functional cement, apatite ionomer cement (AIC), and its anti-bacterial properties compared with glass ionomer cement (GIC) and surface pre-reacted glass-ionomer filler containing composite resin (giomer).

Materials and methods

Conventional GIC (Fuji III, GC Co., Tokyo, Japan) was used as the control and fundamental materials. In the AIC powder, 28% wt of GIC powder was replaced with spherical-shaped hydroxyapatite powder. The giomer, BeautiSealant (Shofu Co., Kyoto, Japan), was used as a positive control. Each specimen was immersed in deionized water and analyzed by inductively coupled plasma atomic emission spectrometry (for Al, Si, P, Ca and Sr) and a fluoride-selective electrode. Antibacterial activity against Streptococcus mutans was evaluated using the adenosine-5'- triphosphate luminescence method.


Concentrations of released ions from AIC specimens were significantly higher than those from GIC and giomer specimens, except for Sr. Regarding antibacterial activity, luminescence intensity of the AIC group (27.2 ± 12.6 RLU) was significantly lower than that of the giomer group (787.4 ± 176.1 RLU).


It was concluded that AIC could be a most suitable material for pit and fissure sealant for enamel remineralization and anti-cariogenic and -bacterial activity.