Gain-of-function mutations in the calcium-sensing receptor (CaSR) result in congenital hypoparathyroidism, characterized by suppressed parathyroid hormone (PTH) secretion, hypocalcemia, hyperphosphatemia and hypercalciuria. Managing hypocalcemia in these patients is challenging, as conventional therapy with calcium and active vitamin D analog supplementation often exacerbates renal complications....

Primary hyperparathyroidism (PHPT) in pregnancy is uncommon and poses challenges in managing it with desired good maternal and fetal outcomes. We report two cases of PHPT in pregnancy with challenges in localizing the lesion, one localized successfully using low dose 99mTc-sestamibi and the other patient required neck exploration....