Open Access DOI:10.23937/2377-9004/1410001
Outcome of Labor in Twin Gestation at a Tertiary Institution in a Developing Nation: A 15-Year Review
Rose Anorlu and Olukayode Akinlaja
Article Type: Review Article | First Published: September 19, 2014
Objective: To describe our experience with twin gestation in a developing nation tertiary institution.
Method: All cases of twin gestation at the Lagos University Teaching Hospital over a 15-year period were retrospectively reviewed.
Results: There were 642 twin births out of a total of 28,472 deliveries, a ratio of 1:44. Peak age at occurrence was 28 with only 6% (39) being grand multipara. 66.4% (426) delivered preterm at about 36 weeks and 74.5% (478) had the leading twin in cephalic pres...
Open Access DOI:10.23937/2378-3516/1410003
Functional Characteristics of COPD Patients Admitted for Acute Pulmonary Embolism
Rodriguez DA, Orozco-Levi M, Miranda F, Mayoral A, Clements JA, Martinez-Llorens J, Ventin C, Bruguera J, Gea J and Molina LL
Article Type: Research Article | First Published: September 10, 2014
Introduction: Chronic Obstructive Pulmonary Disease (COPD) is a known risk factor for pulmonary embolism (PE); however, neither the clinical nor the pulmonary function characteristics are well described in COPD patients admitted for PE. Methods: We conducted a retrospective cohort study of 395 patients admitted for acute PE in a tertiary hospital setting. In COPD patients, clinical characteristics and pulmonary function were compared between the survivor and non-survivor groups during a 3-month ...
Open Access DOI:10.23937/2378-3001/1/1/1001
Deep Brain Stimulation Frequency Modulation in Parkinson Disease - One Size May Not Fit All
Ritesh A. Ramdhani
Article Type: Editorial | First Published: September 11, 2014
Deep Brain Stimulation (DBS) is an effective therapeutic modality for patients with Parkinson's Disease who have developed complications from longstanding levodopa such as dyskinesias and motor fluctuations. It produces robust responses to segmental symptoms (ie, bradykinesia, tremor, rigidity) while attenuating involuntary dyskinetic movements and smoothing out 'on' and 'off' period cycling. The subthalamic nucleus and the globus pallidus internaare widely accepted surgical targets for stimulat...
Open Access DOI:10.23937/2378-3419/1/1/1002
Isnt it the Timing for Physics Guidelines on High Dose Rate (HDR) Brachytherapy for Localized Prostate Cancer?
Yongbok Kim
Article Type: Editorial | First Published: August 23, 2014
Prostate cancer has been known as the most frequently occurring (233,000 estimated new cases in 2014) and the secondly death-causing (29,480 estimated deaths in 2014) for men in the United States of America. Based on the extension of tumor, prostate cancer is staged in the Tumor-Node-Metastasis (TNM) scoring system. Depending upon clinical TNM staging, prostate-specific antigen (PSA) level (ng/mL) and pathologic biopsy denoted as Gleason sum score (GSS), localized prostate cancer patients are ca...
Open Access DOI:10.23937/2378-3397/1410002
Single-Incision Laparoscopic Morgagni Hernia Repair in an Adult
Sharon Monsivais, Nicole E. Sharp, Hannah Vassaur and F. Paul Buckley
Article Type: Case Report | First Published: September 07, 2014
Introduction: This is a case report of a single-incision laparoscopic Morgagni hernia repair. We discuss our initial experience with this technique.
Case Description: A 63-year-old man elected to undergo a single incision laparoscopic Morgagni hernia repairs after diagnostic imaging showed a large fat containing right diaphragmatic hernia. The patient's only preoperative symptom was periodic right sided chest pain....
Open Access DOI:10.23937/2378-3397/1410001
Induced Pluripotent Stem Cells and Heart Failure Therapy
Hongran Wang
Article Type: Editorial | First Published: August 23, 2014
Heart failure is a major public health concern worldwide, and coronary artery disease in particular is the leading cause of death in developed countries. Percutaneous coronary interventions can effectively treat coronary artery disease, but the management of ventricular remodeling and chronic ischemic cardiomyopathy after Myocardial Infarction (MI) remains a challenge. The human heart has very limited regenerative capacity, which is insufficient to replace the cells lost after MI. Stem cell ther...
Open Access DOI:10.23937/2378-3664/1410001
Boron Neutron Capture Therapy of Cancer as a Part of Modern Nanomedicine
Alexander V. Safronov
Article Type: Editorial | First Published: August 16, 2014
Boron neutron capture therapy (BNCT) is a method of cancer therapy with a simple idea behind it. Positioning a certain amount of 10B-enriched boron-containing compounds into tumor cells with subsequent irradiation of the tumor tissue by thermal or epithermal neutrons causes tumor damage and death. The mechanism of the tumor cell damage during BNCT is based on the capture-fission reaction between the boron-10 nucleus and a neutron resulting in an α-particle release inside the cell. A success...