Open Access DOI:10.23937/2469-5726/1510005
Suppression of Experimental Arthritis through AMP-Activated Protein Kinase Activation and Autophagy Modulation
Huimin Yan, Hui-Fang Zhou, Ying Hu and Christine T.N. Pham
Article Type: Research Article | Publication Updated: February 28, 2015
Autophagy plays a central role in various disease processes. However, its contribution to inflammatory arthritides such as rheumatoid arthritis (RA) is unclear. We observed that autophagy is engaged in the K/BxN serum transfer model of RA but autophagic flux is severely impaired. Metformin is an anti-diabetic drug that has been shown to stimulate autophagy. Induction of autophagic flux, through metformin-mediated AMP-activated protein kinase (AMPK) activation and interruption of mammalian target...
Open Access DOI:10.23937/2572-3278.1510003
Insulin Resistance and Diet Care
Jun Kobayashi
Article Type: Editorial | Publication Updated: March 02, 2015
During human evolution, insulin signaling developed to ensure normal homeostasis to redirect nutrients to pivotal organs under critical conditions such as starvation, infection, and trauma. However, in the modern era, insulin signaling is often counter productive due to the current obesogenic environment, resulting in insulin resistance....
Open Access DOI:10.23937/2572-4045.1510004
Simultaneous Liver Kidney Transplantation
Kirk B. Russ and Ashwani K. Singal
Article Type: Editorial | Publication Updated: March 02, 2015
Since the introduction of model for end-stage liver disease (MELD) score in 2002 for listing patients for liver transplantation, frequency and proportion of simultaneous liver kidney (SLK) transplantation has increased by over 300%. This is mainly due to incorporation of renal function and serum creatinine as one of the major factors in determining the MELD score. ...
Open Access DOI:10.23937/2469-5742/1510002
Male Sling: A Decade Later
Ajay Singla
Article Type: Editorial | Publication Updated: February 28, 2015
Urethral compression provided by a male sling is not a new concept. A variety of urethral compression procedures have been applied in an attempt to control urinary incontinence over the years. Most notable were the Kaufman procedures which used silicone gel prosthesis to compress the ventral urethra....
Open Access DOI:10.23937/2572-4045.1510002
Stem Cell Transplantation (SCT) to Treat Severe Refractory Multiple Sclerosis (MS)
Athanasia Mouzaki
Article Type: Editorial | Publication Updated: February 23, 2015
Multiple Sclerosis usually affects young adults aged between 20 to 40 years, although it can begin earlier or later in life. Women are affected almost twice as often as men. Symptoms include sensory disturbances in the limbs, optic nerve dysfunction, pyramidal tract dysfunction, bladder or bowel dysfunction, sexual dysfunction, ataxia and diplopia. ...
Open Access DOI:10.23937/2469-5734/1510003
Dental Implant Therapy in Patients Affected by Oral Mucosal Diseases
Sertan Ergun
Article Type: Short Communication | Publication Updated: March 02, 2015
Dental implants are increasingly used for the treatment of complete and /or partial eduntulism. Related literature search revealed that dental implants are associated with high survival rates of close 92-98% after 10 years. The success of implant therapy is very close associated with the appropriate patient selection....
Open Access DOI:10.23937/2469-5734/1510001
Editor's Note: Inaugural Issue of the International Journal of Oral and Dental Health
James L. Borke
Article Type: Editorial | Publication Updated: February 23, 2015
It is my distinct honor and pleasure to have my remarks included in the inaugural issue of The International Journal of Oral of Dental Health. With the accelerated rate of change brought on by global connectivity and the rapid advance of new technologies, the birth of this 21st century journal addressing current issues in oral and dental health is a welcome addition to the field for clinicians and researchers alike....