Open Access DOI:10.23937/2469-5866/1510003
Benefits of Temporary Intrathecal Baclofen Therapy: Management of Tone and Spasticity
Melissa Ann Eppinger, Thomas J. Sernas and Catherine Anne Mazzola
Article Type: Case Series | First Published: September 9, 2015
Spasticity and dystonia may develop as a consequence of brain or spinal cord injury (SCI). Central nervous system (CNS) injury may be permanent or temporary, depending on the etiology of brain or spinal cord injury. In anoxic brain injury, there may be transient or reactive demyelination due to cell death or cell dysfunction. If there is ischemia without true infarction, or cell death, there may be some ability of the brain to repair itself or reconstitute the myelination of axons within the whi...
Open Access DOI:10.23937/2469-5777/1510009
Gun Shot Wound to Left Chest with 'Transmediastinal' Trajectory. A Case Report and Review
Reilly D. Hobbs, Joshua A. Marks, John C. Kucharczuk and Patrick M. Reilly
Article Type: Case Report | First Published: September 18, 2015
A 21-year old African American male presented with a single gunshot wound to the left posterior chest inferior and medial to the scapular spine. EMS performed a left needle thoracostomy for tension pneumothorax. In the trauma bay, the patient was hemodynamically stable with a GCS 15 and moving all extremities. A chest tube was placed with an initial output of 700 mL of blood and the patient was intubated. A portable chest radiograph demonstrated a bullet overlying the right inferior hilum....
Open Access DOI:10.23937/2469-5777/1510007
Analysis of a Clinically Failed, Mechanically Intact, Reconstructive Compression Plate
Bharadwaj Cheruvu, Sunil Karmacharya, Richard Laughlin and Tarun Goswami
Article Type: Research Article | First Published: September 07, 2015
A reconstructive orthopedic bone plate was submitted for analysis. Traditional failure analysis methods were used to assess the mode of the plate failure. Metallographic investigation of the plate was carried out in this report. Since limited data was available in the literature and clinical data related to subject demography, date of removal as well as reasons for removal unknown, in depth analysis was not possible. However, the plate was received in in-tact condition with minor biological depo...
Open Access DOI:10.23937/2378-3419/2/4/1023
A Derivative of Differentiation-Inducing Factor-3 Inhibits PAK1 Activity and Breast Cancer Cell Proliferation
Peter Oladimeji, Yuzuru Kubohara, Haruhisa Kikuchi, Yoshiteru Oshima, Courtney Rusch, Rebekah Skerl, Maria Diakonova
Article Type: Original Article | First Published: September 17, 2015
Differentiation-inducing factors 1-3 (DIFs 1-3), chlorinated alkylphenones identified in the cellular slime mold Dictyostelium discoideum, are considered anti-tumor agents because they inhibit proliferation of a variety of mammalian tumor cells in vitro. Although the anti-proliferative effects of DIF-1 and DIF-3 are well-documented, the precise molecular mechanisms underlying the actions of DIFs have not been fully elucidated. In this study, we examined the effects of DIFs and their derivatives ...
Open Access DOI:10.23937/2378-3656/1410057
Breast Cancer Adjacent to Nodular Fasciitis: A Case Report
Ryuji Takahashi, Ayaka Ishii, Roka Namoto Matsubayashi, Shino Nakagawa, Momoko Akashi, Kana Tsutsui, Shino Harada, Seiya Momosaki and Yoshito Akagi
Article Type: Review Article | First Published: September 12, 2015
Nodular fasciitis is a benign proliferative lesion that is generally found in the soft tissue of the upper extremity and trunk. It has rarely been reported in the breast and that of the breast is indistinguishable from breast cancer.A 77-year-old woman visited our department to biopsy the swelled axillary lymph node. Contemporary, a breast tumor was found in her left breast. Mammography showed a high density mass with microlobulated margin. On ultrasonography, there was an irregular hypoechoic m...
Open Access DOI:10.23937/2378-3656/1410055
Some Aspect of Clinical Assessment of Carpal Unstability and Colapsus in Untreated Rheumatoid Arthritis
Dejan Spasovski
Article Type: Research Article | First Published: September 08, 2015
The carpal instability is a biomechanical alteration with multiple pathogenesis. It ensues due to disturbance of the normal ligament and bone connections that control the wrist. There are four major types of carpal instability: 1 Dorsal Intercalated Segment Instability (DISI) 2.Volar Intercalated Segment Instability (VISI) 3.Ulnar translocation, and 4. Medial carpal instability. Instability in the wrist in Rheumatoid Arthritis (RA) appears as a result of incongruity between joint and bone surfac...
Open Access DOI:10.23937/2378-2951/1410049
Heart Transplant for Dextrocardia Situs Inversus with Very Complex Congenital Lesion: a Challenge of Cardiac Surgery
Nguyen Huu Uoc and Pham Tien Quan
Article Type: Research Article | First Published: September 14, 2015
27 year-old female patient had complex CHD that involved dextrocardia situs inversus, double outlet right ventricle type TGA, pulmonary artery stenosis, total atrio-ventricular canal, and total anomalous pulmonary venous connection type supra-cardia. She was experiencing end-stage heart failure and severely cachexia with risk of death within few months. The transplanted heart was from a multi-organ donor; male, 26 years old, normal heart structure. Although the difference in biological parameter...
Open Access DOI:10.23937/2378-2951/1410048
Arrhythmic Manifestation of Prinzmetal' Sangina Induced by Therapeutic Hypothermia
Abellas-Sequeiros RA, Ocaranza-Sanchez R, Garcia-Acuna JM and Gonzalez-Juanatey JR
Article Type: Case Report | First Published: September 03, 2015
We report the case of a 37-year-old Caucasian man, with prior history of smoking and DM. He had complained about multiple episodes of syncope during last year. However, the day of his hospitalization, he described a sudden and acute episode of chest pain which stopped him from sleeping. He arrived to the emergency department after 45 minutes of successful resuscitation, with VF as first cardiac rhythm detected....