Open Access DOI:10.23937/2469-5831/1510008
A Constrained Non-inferiority Approach for Assessing Clinical Efficacy to Establish Biosimilarity
Jason JZ Liao
Article Type: Research Article | First Published: December 3, 2015
To develop a biosimilar product, it is necessary to demonstrate biosimilarity between the proposed biosimilar product and the reference product in terms of the purity, potency, efficacy, and safety. In this paper, clinical efficacy data required for establishing biosimilarity are considered. Non-inferiority (NI) and equivalence methods are commonly used for analyzing clinical trials to meet this requirement. The equivalence approach often requires large, costly, and lengthy clinical trials....
Open Access DOI:10.23937/2572-3278.1510009
Cross-Sectional Exploration on Feeding Practices of Feeders towards Preschoolers' Picky Eating Behaviors
Louisa Ming Yan Chung and Shirley Siu Ming Fong
Article Type: Original Article | First Published: November 14, 2015
Picky eating is quite common among preschoolers, which may lead to imbalanced diet. Picky eating behavior among preschoolers was found associated with feeding style. With the complex family structure of 2-career parents in Hong Kong and unique authoritarian Chinese feeding style, this study aimed to explore the differences in feeding practices among different preschoolers' feeding persons and to investigate if preschoolers' picky eating showed differences if they are fed by different feeding per...
Open Access DOI:10.23937/2572-407X.1510005
Effect of Race/Ethnicity and Smoking on Diurnal Variations in Testosterone Levels
Ram B Jain
Article Type: Research article | First Published: December 10, 2015
The effect of race/ethnicity and smoking on diurnal variations in total serum testosterone level (T-TST) was evaluated by analyzing data from NHANES for 2011-2012 for adolescent and adult males. For adolescent males, diurnal variability in T-TST levels was substantially smaller among smokers than nonsmokers for non-Hispanic white (NHW) and Hispanics but the reverse was true for non-Hispanic black (NHB). For adult males, morning levels of T-TST were 21-31% higher than the T-TST levels during even...
Open Access DOI:10.23937/2572-407X.1510004
Thyroid Profile of the Reference United States Population: Data from NHANES 2007-2012
Ram B Jain
Article Type: Research article | First Published: November 16, 2015
Objective: This study was undertaken to describe the thyroid profile of reference U.S. population including generating reference ranges for thyroid stimulating hormone (TSH), free and total triiodothyronine (FT3, TT3), free and total thyroxine (FT4, TT4), and thyroglobulin. Design and methods: Publically available data from National Health and Nutrition Examination Survey (NHANES) for the cycles 2007-2012 were analyzed for this purpose....
Open Access DOI:10.23937/2572-4045.1510013
The Impact of Renal Transplantation on Lower Limb Perfusion
Paul Alexander, Emma Aitken, David Mansouri and David Kingsmore
Article Type: Research Article | First Published: November 25, 2015
The benefits of renal transplantation are now more accessible to older, more comorbid patients. Currently, those with peripheral vascular disease are often excluded partly due to the theoretical risk of post transplantation limb ischemia, where blood is diverted away from an already under-perfused leg. This study aims to determine if renal transplantation affects lower limb perfusion....
Open Access DOI:10.23937/2572-4045.1510012
Infection after Pediatric Living Related Liver Transplantation: Timing, Types and Risk Factors
Behairy El-Sayed Behairy, Hatem Abdel-Sattar Konsowa, Haidy Mohammed Zakaria, Osama Hegazy Abd-Elsalam and Mostafa Mohamed Sira
Article Type: Research Article | First Published: November 16, 2015
The study was a retrospective cohort. It included 27 pediatric patients underwent liver transplantation (LTx). All patients' records were reviewed. A wide range of potential risk factors for infection and post-transplant complications were recorded. Follow-up data were collected for 1.5 years post-transplant, every infection attack during this period were subjected to detailed risk analysis....
Open Access DOI:10.23937/2572-4037.1510008
Assistive Technology for Promoting Adaptive Skills of Children with Autism Spectrum Disorders: A Literature Overview
Fabrizio Stasolla, Adele Boccasini, Viviana Perilli, Rita Damiani and Vincenza Albano
Article Type: Review Article | First Published: November 25, 2015
Individuals with autism spectrum disorders are commonly described with emotional, intellectual, communicative and social impairments. They are frequently isolated and passive with few opportunities of positive and constructive interaction with the outside world. Accordingly, they may exhibit withdrawal, stereotypic and challenge behaviors. The aforementioned conditions might seriously hamper their social image and status, with negative consequences on their quality of life....
Open Access DOI:10.23937/2572-4037.1510007
Mentalization Based Group Psychotherapy for Psychosis: A Pilot Study to Assess Safety, Acceptance and Subjective Efficacy
Fernando Lana, Susana Marcos, Laia Molla, Ana Vilar, Victor Perez, Mireia Romero and Josep Marti
Article Type: Research Article | First Published: November 16, 2015
Systematic reviews of psychodynamic psychotherapy for individuals with psychosis have reported mixed results. However, mentalization-based therapy (MBT), a manualized psychodynamic psychotherapy, has been proven effective in controlled studies in non-psychotic patients with severe mental disorders. Although MBT is currently being used to treat psychotic patients, to date no studies have evaluated outcomes and treatment-related adverse effects....
Open Access DOI:10.23937/2572-4010.1510009
Overweight/Obesity and Cardiovascular Risk in the Eastern Morocco
El Bakkay Sellam and Abdellatif Bour
Article Type: Review Article | First Published: December 05, 2015
Epidemiological Study Transversal on 624 women of childbearing age healthy and not pregnant. The study was conducted in prefecture of Oujda-Angad. Data on socioeconomic and demographic level were collected using a questionnaire. Anthropometric measurements were determined according to the WHO standards. Medical tests were performed in a laboratory accredited private analysis in Oujda. The data were processed using SPSS....
Open Access DOI:10.23937/2572-4010.1510008
The Effects of Weight Loss on Blood Rheology in Obese Patients
Maciej Wiewiora, Jerzy Piecuch and Krystyn Sosada
Article Type: Review Article | First Published: November 12, 2015
Hemorheological alterations in obesity, including disturbances in the blood's rheological behavior such as increased blood and plasma viscosity and enhanced red blood cell (RBC) aggregation, have been reported by various authors. Blood and plasma viscosity are risk factors for arteriosclerosis. Other studies have shown that erythrocyte rheological changes have been observed in patients with hypertension and diabetes mellitus, which are more often associated with obesity....