Open Access DOI:10.23937/2572-4053.1510005
Sleep Pattern during Pregnancy and Maternal Depression: Study of Aube Cohort
Flora Bat-Pitault, Christine Deruelle, Sophie Flori, Veronique Porcher-Guinet, Camille Stagnara, Aurore Guyon, Sabine Plancoulaine, Joelle Adrien, David Da Fonseca, Hugues Patural and Patricia Franco
Article Type: Original Article | First Published: September 26, 2015
217 women recruited in childbirth in the maternity participated in the survey with 34 included in the MDD group. 17 among the MDD group were diagnosed PPMD. Sleep characteristics of women were assessed before and during pregnancy with self-administered questionnaires and depressive symptoms after delivery were screen with the hospital anxiety depression scale (HAD). Diagnosis of depression was performed according to DSM-IV criteria during a semi-structured interview done by phone....
Open Access DOI:10.23937/2572-4053.1510004
Kyphosis and Sleep Characteristics in Older Persons: The Rancho Bernardo Study
Che Wankie, D. Kritz-Silverstein, E. Barrett-Connor and D.M. Kado
Article Type: Original Article | First Published: September 21, 2015
Accentuated kyphosis, popularly known as the dowager's hump, is a forward curvature of the thoracic spine that appears as a humped or crooked back. Progressive kyphosis may develop as a result of spinal fractures caused by osteoporosis, postural changes due to muscle weakness, and/or degenerative disc disease. Hyperkyphosis is a common condition affecting 20-40% of older persons, but can occur less commonly among the young. In older persons, hyperkyphosis has been associated with falls, fracture...
Open Access DOI:10.23937/2474-1353/1510006
Does Human Papillomavirus Affect Pregnancy Outcomes? An Analysis of Hospital Data 2012-2014
Harpriya Kaur, Delf Schmidt-Grimminger, Steven W Remmenga, Baojiang Chen, KM M Islam and Shinobu Watanabe-Galloway
Article Type: Original Research Article | First Published: December 8, 2015
Human Papillomavirus (HPV) is the most common sexually transmitted infection in the United States. Pregnant women are at higher risk of HPV infection because during pregnancy major physiological and immunological changes take place that modulate the functioning of the immune system and may cause changes in HPV replication. These changes may also make the clearance of HPV much more difficult. HPV infection can impair extra villious trophoblast invasion into the uterine wall by increasing the rate...
Open Access DOI:10.23937/2474-1353/1510004
Pregnancy after Rape
Gerald D. Coleman
Article Type: Review Article | First Published: November 02, 2015
This essay provides a brief and broad overview of rape, leading to a discussion of pregnancy after rape. This discussion focuses on myths and misinformation as well as research-based evidence pertaining to the likelihood of pregnancy occurring due to rape, perceptions of rape-related pregnancy, abortion following rape-related pregnancy, and perspectives on appropriate health care responses to pregnancy due to rape....
Open Access DOI:10.23937/2474-1353/1510003
Interstitial Brachytherapy for Locally Advanced Cervical Cancer
Nathan Denlinger, Nicole Nolan, Kristin Bixel, Ritu Salani, Douglas Martin and Allison M. Quick
Article Type: Research Article | First Published: October 21, 2015
Retrospective analysis was performed on patients treated for cervical cancer at the Ohio State University Wexner Medical Center from 2000 to 2014. A total of 525 patients were identified and 52 of these patients received interstitial brachytherapy and were included in the analysis. All patients received external beam radiation. All patients were treated with low-dose-rate interstitial brachytherapy, except for one patient who was treated with high-dose-rate interstitial brachytherapy. Actuarial ...
Open Access DOI:10.23937/2378-3419/2/5/1035
Fascin is Expressed in Basal-Liketype Triple Negative Breast Cancer Associated with High Malignant Potential in Japanese Women
Hiromichi Tsuchiya, Akiko Sasaki, Yuko Tsunoda, Masafumi Takimoto, Terumasa Sawada, Seigo Nakamura, kentaro Iijima and Katsuji Oguchi
Article Type: Original Article | First Published: December 07, 2015
No molecular targeted drug has been developed for poor-prognostic triple-negative breast cancer (TNBC) because it has no hormone or human epidermal growth factor receptor 2 (HER2) sensitivity. In addition, TNBC has recently been sub classified into 6 types. In this study, we analyzed the expression of Fascin, an actin-binding protein associated with breast cancer, in 301 invasive breast cancer samples. Of these, 32 were identified as TNBC and were classified into the basal-like type and other no...
Open Access DOI:10.23937/2378-3419/2/5/1034
Palliative Management of Malignant Bowel Obstruction with Carcinomatosis
Kirti Joseph, Jaclyn Schneider and Amy A Case
Article Type: Case Report | First Published: November 27, 2015
Mr. H was a 73 year old male with a past medical history of lumbar spinal degenerative disease, pyloric stenosis repair as a child and a Hartmann procedure for a perforated diverticulitis at age 43, with colostomy reversal shortly after. In August of 2014 he was diagnosed with stage 4 colon cancer, with extensive metastases to the lung including large masses that invaded into the airways as well as a right middle and upper lobe mass compressing the superior vena cava. He underwent and assisted l...
Open Access DOI:10.23937/2378-3419/2/5/1033
C4.4A and Aldehyde Dehydrogenase 1 (ALDH1) May Contribute to breast Cancer not Mediated Through epithelial-Mesenchymal Transition
Natsuko Inoue, Takahiro Watanabe, Seiichi Hirota, Masahisa Ohtsuka, Hirofumi Yamamoto, Koji Morimoto, Toyomasa Katagiri and Yasuo Miyoshi
Article Type: Short Communication | First Published: November 11, 2015
C4.4A, a glycosylphosphatidyl-inositol-anchored membrane protein, plays an important role in epithelial-mesenchymal transition (EMT) affecting progression of colorectal cancer, while aldehyde dehydrogenase 1 (ALDH1) has been identified as a stem cell marker for breast cancer. Since cancer stem cells link to EMT phenotype, both molecules seem to be important for breast cancer progression mediated via EMT. In this study, associations between expressions of C4.4A or ALDH1 and vimentin, a mesenchyma...
Open Access DOI:10.23937/2378-3419/2/5/1032
Feasibility and Efficacy of Definitive Hypofractionated High-Dose Radiotherapy for Cutaneous Angiosarcoma of the Scalp
Emiko Shimoda, Kazuya Inoue, Nobuhide Wakai, Yoko Morimoto, Isao Asakawa, Nobumasa Fujitani, Tadashi Yoshimine, Tetsuro Tamamoto, Maiko Takeda, Kohei Ogawa, Hideo Asada and Masatoshi Hasegawa
Article Type: Original Article | First Published: November 03, 2015
Cutaneous angiosarcoma is a rare but highly aggressive vascular tumor resistant to all treatment modalities available. The aim of this study was to analyze the treatment outcomes of patients who received definitive hypofractionated high-dose radiotherapy (RT) for angiosarcoma of the scalp. Between April 2008 and December 2014, 11 patients with histologically proven cutaneous angiosarcoma of the scalp visited our Department of Radiation Oncology, because dermatologists suggested that there was no...