Open Access DOI:10.23937/2469-584X/1510029
Discordance Between Endoscopic & Histological Findings Warrant a Reassessment of the Pathological Specimen
Koh ZL Sharon, Yamamoto H and Tsang BS Charles
Article Type: Case Report | First Published: July 01, 2016
We report a 52-year-old man who underwent a screening colonoscopy, which revealed a sessile rectal polyp with neoplastic features on magnified chromo-endoscopy. Based on pit pattern analysis and endoscopic Ultrasound (EUS), Endoscopic Submucosal Dissection (ESD) was performed for a presumptive diagnosis of an early rectal neoplastic lesion (limited to the mucosa and upper third of the submucosa). Histopathological examination however reported it to be a submucosal rectal lipoma with overlying re...
Open Access DOI:10.23937/2469-584X/1510028
Colonic Lipoma: Incidental and Urgent Management, Report of Two Cases and Review of the Literature
Justo I, Marcacuzco A, Caso O, Cambra F, Garcia-Nebreda M, Nutu A, Rivas C and Jimenez C
Article Type: Case Series | First Published: May 29, 2016
Lipomas are benign tumors rarely found in the digestive tract, particularly rare in the colon, that were first described by Bauer in 1757 as an unusual cause of intussusception in the adult. Lipomas are most often small, asymptomatic and identified as incidental findings during colonoscopy. Nonetheless, up to 25% are symptomatic in the form of abdominal pain, bleeding, diarrhea or intussusception. Ninety percent of lipomas in the colon are located at the submucosal layer, with only few originati...
Open Access DOI:10.23937/2469-584X/1510027
Abdominal Upper Gi Injury in 416 Polytraumatized Patients
Matthias Heuer, Bjorn Hussmann, Rolf Lefering, Gernot M Kaiser, Sven Lendemans and TraumaRegister DGU
Article Type: Original Research | First Published: May 29, 2016
In multiple-injury patients, the stomach and duodenum are part of the injury pattern to varying degrees in around 0.5-2% of the documented cases. In industrialized countries, abdominal injuries are mostly caused by a blunt accident mechanism. And yet, the abdominal upper GI injury is frequently not directly life-threatening. In 30-40% of the cases, complications occur, which may lead to a significant reduction in quality of life, e.g. due to nutrition problems and/or in chronic post-traumatic/ -...
Open Access DOI:10.23937/2469-5750/1510026
Rosacea: A Potential Risk for Parkinson's Disease Development
Jose D Cordoba and Erwin E Argueta
Article Type: Review Article | First Published: May 04, 2016
Rosacea and Parkinson's disease (PD) are two completely different pathologies, with different outcomes, that share a common interesting feature as their proposed originating factor. Both conditions show inflammation as a pre-dominant aspect of their pathogenesis, having an important role in the excessive breakdown of connective tissue components. Metalloproteinases (MMPs) and Toll-like receptors (TLRs) are present in the skin and brain in physio-logical conditions, but can be significantly up re...
Open Access DOI:10.23937/2469-5750/1510025
Refractory Perianal Ulcers in a Neonate. Beyond the Diaper Rash
Khodayar-Pardo Parisa, Sanchez Mari Maria and Lopez Garcia M Jose
Article Type: Short Note | First Published: May 02, 2016
The diaper rash is a common medical query in pediatric offices. Most of the time it is due to a contact dermatitis or mild infection that only requires local care for its resolution. The appearance of more severe lesions, such as ulcers, and the resistance to conventional therapy should make us suspect the existence of an underlying disease....
Open Access DOI:10.23937/2469-570X/1410031
Epigenetic Loss of MLH1 Expression in Normal Human Hematopoietic Stem Cell Clones is Defined by the Promoter CpG Methylation Pattern Observed by High-Throughput Methylation Specific Sequencing
Jonathan Kenyon, Gabrielle Nickel-Meester, Yulan Qing, Gabriela Santos-Guasch, Ellen Drake, PingfuFu, Shuying Sun, Xiaodong Bai, David Wald, Eric Arts and Stanton L. Gerson
Article Type: Short Review | First Published: May 24, 2016
Normal human hematopoietic stem and progenitor cells (HPC) lose expression of MLH1, an important mismatch repair (MMR) pathway gene, with age. Loss of MMR leads to replication dependent mutational events and microsatellite instability observed in secondary acute myelogenous leukemia and other hematologic malignancies. Epigenetic CpG methylation upstream of the MLH1 promoter is a contributing factor to acquired loss of MLH1 expression in tumors of the epithelia and proximal mucosa....
Open Access DOI:10.23937/2378-3516/1410048
Prevalence of Chronic Obstructive Pulmonary Disease in Southwestern Taiwan: A Population-Based Study
Su-Lun Hwang, Yu-Ching Lin, Su-Er Guo, Miao-Ching Chi, Chiang-Ting Chou and Chieh-Mo Lin
Article Type: Original Research Article | First Published: May 23, 2016
Objective: Chronic obstructive pulmonary disease (COPD) poses a substantial burden of illness in the Asia-Pacific region, as it does worldwide. However large-scale and community-based epidemiology studies of COPD in Taiwan are limited. This paper conducted a population-based study to investigate the prevalence of COPD in southwestern Taiwan. Methods: Data were conducted using a subset of medical claims data from the National Health Insurance Research database (NHIRD) from 2008 to 2010. The preva...
Open Access DOI:10.23937/2378-3516/1410046
Left Hemi-Diaphragmatic Hydatid Cyst - A Rare Presentation and Diagnostic Challenge
Haris Hakeem, Ghulam Fareed, Muhammad Irfan and Saulat Fatmi
Article Type: Case Report | First Published: April 22, 2016
Echinococcosis or hydatid cyst disease is among the oldest diseases known to man. Common presentations include involvement of liver and lungs. Hydatid cyst in diaphragm without hepatic involvement is rare and less than 100 cases are reported in literature. We are describing a case of a young female who presented with cough anddyspnea secondary to large cysts that appeared to involve the right lung and spleen on initial imaging studies. Peroperatively, however, the presumed spleenic cystwas surpr...